Host-pathogen interaction of human coronaviruses - interferon induction (WP4880)

Homo sapiens

Figure 8 of review.


Friederike Ehrhart , Egon Willighagen , Alex Pico , Chris Evelo , Eric Weitz , Finterly Hu , and Nhung Pham


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Homo sapiens




Pathway Ontology

signaling pathway type I interferon signaling pathway

Disease Ontology

severe acute respiratory syndrome viral infectious disease


Label Type Compact URI Comment
MAVS GeneProduct ensembl:ENSG00000088888
TICAM1 GeneProduct ncbigene:148022 TRIF
IFIH1 GeneProduct ensembl:ENSG00000115267 MDA5
DDX58 GeneProduct ensembl:ENSG00000107201 RIG1
RIPK1 GeneProduct ensembl:ENSG00000137275 RIP1
IKBKE GeneProduct ensembl:ENSG00000263528
IRF3 GeneProduct ensembl:ENSG00000126456
TRAF6 GeneProduct ensembl:ENSG00000175104
CHUK GeneProduct ensembl:ENSG00000213341 IKKα, IκB kinase α
MYD88 GeneProduct ensembl:ENSG00000172936
IKBKB GeneProduct ensembl:ENSG00000104365 IKKb, IκB kinase b
TRAF3 GeneProduct ensembl:ENSG00000131323
NFKB1 GeneProduct ensembl:ENSG00000109320 NFKB not specified
TBK1 GeneProduct ensembl:ENSG00000183735
JAK1 GeneProduct ensembl:ENSG00000162434
TLR7 GeneProduct ensembl:ENSG00000196664
IKBKG GeneProduct ensembl:ENSG00000269335 NEMO
NFKBIA GeneProduct ensembl:ENSG00000100906 IκBα, NF-κB inhibitor alpha
OAS1 GeneProduct ensembl:ENSG00000089127
PKR GeneProduct ensembl:ENSG00000055332
MAP3K7 GeneProduct ensembl:ENSG00000135341 TAK1
MAPK8 GeneProduct ensembl:ENSG00000107643
MAPK14 GeneProduct ensembl:ENSG00000112062
JUN GeneProduct ensembl:ENSG00000177606 NFKB not specified
FOS GeneProduct ensembl:ENSG00000170345 NFKB not specified
IFNAR1 GeneProduct ensembl:ENSG00000142166
IFNAR2 GeneProduct ensembl:ENSG00000159110
TYK2 GeneProduct ensembl:ENSG00000105397
STAT1 GeneProduct ensembl:ENSG00000115415
STAT2 GeneProduct ensembl:ENSG00000170581
IRF9 GeneProduct ensembl:ENSG00000213928
OAS2 GeneProduct ensembl:ENSG00000111335
OAS3 GeneProduct ensembl:ENSG00000111331
PLpro (nsp3) Protein refseq:YP_009725299.1
6 Protein uniprot:P59634 PDB structure for SARS-CoV strain: 6JYT
M Protein uniprot:P59596 PDB structure for SARS-CoV strain: 6JYT
N Protein wikidata:Q89457519 PDB structure for SARS-CoV strain: 6JYT
9b Protein uniprot:P59636 PDB structure for SARS-CoV strain: 6JYT
E Protein uniprot:P59637 PDB structure for SARS-CoV strain: 6JYT
S Protein uniprot:694009 PDB structure for SARS-CoV strain: 6JYT
3a Protein uniprot:P59632 PDB structure for SARS-CoV strain: 6JYT
7a Protein uniprot:P59635 PDB structure for SARS-CoV strain: 6JYT
3b Protein uniprot:P59633 PDB structure for SARS-CoV strain: 6JYT


  1. Human Coronavirus: Host-Pathogen Interaction. Fung TS, Liu DX. Annu Rev Microbiol. 2019 Sep 8;73:529–57. PubMed Europe PMC Scholia