Host-pathogen interaction of human coronaviruses - interferon induction (WP4880)
Homo sapiens
Figure 8 of review.
Authors
Friederike Ehrhart , Egon Willighagen , Alex Pico , Chris Evelo , Eric Weitz , Finterly Hu , and Nhung PhamActivity
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Cited In
- An endogenously activated antiviral state restricts SARS-CoV-2 infection in differentiated primary airway epithelial cells (2022).
- Bioinformatics and systems-biology analysis to determine the effects of Coronavirus disease 2019 on patients with allergic asthma (2022).
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Organisms
Homo sapiensCommunities
COVID-19Annotations
Pathway Ontology
signaling pathway type I interferon signaling pathwayDisease Ontology
severe acute respiratory syndrome viral infectious diseaseLabel | Type | Compact URI | Comment |
---|---|---|---|
MAVS | GeneProduct | ensembl:ENSG00000088888 | |
TICAM1 | GeneProduct | ncbigene:148022 | TRIF |
IFIH1 | GeneProduct | ensembl:ENSG00000115267 | MDA5 |
DDX58 | GeneProduct | ensembl:ENSG00000107201 | RIG1 |
RIPK1 | GeneProduct | ensembl:ENSG00000137275 | RIP1 |
IKBKE | GeneProduct | ensembl:ENSG00000263528 | |
IRF3 | GeneProduct | ensembl:ENSG00000126456 | |
TRAF6 | GeneProduct | ensembl:ENSG00000175104 | |
CHUK | GeneProduct | ensembl:ENSG00000213341 | IKKα, IκB kinase α |
MYD88 | GeneProduct | ensembl:ENSG00000172936 | |
IKBKB | GeneProduct | ensembl:ENSG00000104365 | IKKb, IκB kinase b |
TRAF3 | GeneProduct | ensembl:ENSG00000131323 | |
NFKB1 | GeneProduct | ensembl:ENSG00000109320 | NFKB not specified |
TBK1 | GeneProduct | ensembl:ENSG00000183735 | |
JAK1 | GeneProduct | ensembl:ENSG00000162434 | |
TLR7 | GeneProduct | ensembl:ENSG00000196664 | |
IKBKG | GeneProduct | ensembl:ENSG00000269335 | NEMO |
NFKBIA | GeneProduct | ensembl:ENSG00000100906 | IκBα, NF-κB inhibitor alpha |
OAS1 | GeneProduct | ensembl:ENSG00000089127 | |
PKR | GeneProduct | ensembl:ENSG00000055332 | |
MAP3K7 | GeneProduct | ensembl:ENSG00000135341 | TAK1 |
MAPK8 | GeneProduct | ensembl:ENSG00000107643 | |
MAPK14 | GeneProduct | ensembl:ENSG00000112062 | |
JUN | GeneProduct | ensembl:ENSG00000177606 | NFKB not specified |
FOS | GeneProduct | ensembl:ENSG00000170345 | NFKB not specified |
IFNAR1 | GeneProduct | ensembl:ENSG00000142166 | |
IFNAR2 | GeneProduct | ensembl:ENSG00000159110 | |
TYK2 | GeneProduct | ensembl:ENSG00000105397 | |
STAT1 | GeneProduct | ensembl:ENSG00000115415 | |
STAT2 | GeneProduct | ensembl:ENSG00000170581 | |
IRF9 | GeneProduct | ensembl:ENSG00000213928 | |
OAS2 | GeneProduct | ensembl:ENSG00000111335 | |
OAS3 | GeneProduct | ensembl:ENSG00000111331 | |
PLpro (nsp3) | Protein | refseq:YP_009725299.1 | |
6 | Protein | uniprot:P59634 | PDB structure for SARS-CoV strain: 6JYT |
M | Protein | uniprot:P59596 | PDB structure for SARS-CoV strain: 6JYT |
N | Protein | wikidata:Q89457519 | PDB structure for SARS-CoV strain: 6JYT |
9b | Protein | uniprot:P59636 | PDB structure for SARS-CoV strain: 6JYT |
E | Protein | uniprot:P59637 | PDB structure for SARS-CoV strain: 6JYT |
S | Protein | uniprot:694009 | PDB structure for SARS-CoV strain: 6JYT |
3a | Protein | uniprot:P59632 | PDB structure for SARS-CoV strain: 6JYT |
7a | Protein | uniprot:P59635 | PDB structure for SARS-CoV strain: 6JYT |
3b | Protein | uniprot:P59633 | PDB structure for SARS-CoV strain: 6JYT |
References
- Human Coronavirus: Host-Pathogen Interaction. Fung TS, Liu DX. Annu Rev Microbiol. 2019 Sep 8;73:529–57. PubMed Europe PMC Scholia