Histone modifications (WP2369)
Histones can undergo many post-translational modifications that are involved in transcription regulation. This pathway provides an overview of various modifications for histones H3 and H4 and the enzymes that catalyze the modifications, where known. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2369 CPTAC Assay Portal]
AuthorsEgon Willighagen , Kristina Hanspers , Alex Pico , Linda Rieswijk , Martina Summer-Kutmon , and Eric Weitz
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- A Maternal High-Fat Diet during Early Development Provokes Molecular Changes Related to Autism Spectrum Disorder in the Rat Offspring Brain (2021).
- Network-based identification of key master regulators associated with an immune-silent cancer phenotype (2021).
- Proteostasis regulators modulate proteasomal activity and gene expression to attenuate multiple phenotypes in Fabry disease (2020).
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Pathway Ontologyaltered transcription pathway
- Regulation of chromatin structure by site-specific histone H3 methyltransferases. Rea S, Eisenhaber F, O’Carroll D, Strahl BD, Sun ZW, Schmid M, et al. Nature. 2000 Aug 10;406(6796):593–9. PubMed Europe PMC Scholia
- COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. Krogan NJ, Dover J, Khorrami S, Greenblatt JF, Schneider J, Johnston M, et al. J Biol Chem. 2002 Mar 29;277(13):10753–5. PubMed Europe PMC Scholia
- Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression. Strahl BD, Grant PA, Briggs SD, Sun ZW, Bone JR, Caldwell JA, et al. Mol Cell Biol. 2002 Mar;22(5):1298–306. PubMed Europe PMC Scholia
- Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D. Genes Dev. 2002 Nov 15;16(22):2893–905. PubMed Europe PMC Scholia
- A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Schotta G, Lachner M, Sarma K, Ebert A, Sengupta R, Reuter G, et al. Genes Dev. 2004 Jun 1;18(11):1251–62. PubMed Europe PMC Scholia