Photodynamic therapy-induced AP-1 survival signaling (WP3611)

Homo sapiens

Photodynamic therapy may induce an acute stress response mediated by mitogen-activated protein kinase kinase kinase 5 (MAP3K5), its downstream MAPKs that target c-Jun N-terminal kinase (JNK, MAPK8) and p38MAPK, and the transcription factors of the activator protein 1 (AP-1) family.


Ruud Weijer , Kristina Hanspers , Friederike Ehrhart , Alex Pico , and Eric Weitz


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Homo sapiens



Disease Ontology


Pathway Ontology

altered regulatory pathway


Label Type Compact URI Comment
TRAF6 GeneProduct ncbigene:7189
PDGFRA GeneProduct ncbigene:5156
MAPK11 GeneProduct ncbigene:5600
JUNB GeneProduct ncbigene:3726
IL6 GeneProduct ncbigene:3569
HSP90AA1 GeneProduct ncbigene:3320
IL2 GeneProduct ncbigene:3558
TRAF5 GeneProduct ncbigene:7188
IFNG GeneProduct ncbigene:3458
TNFSF10 GeneProduct ncbigene:8743
TNF GeneProduct ncbigene:7124
CCND1 GeneProduct ncbigene:595
TRAF2 GeneProduct ncbigene:7186
MAPK13 GeneProduct ncbigene:5603
FOS GeneProduct ncbigene:2353
MMP2 GeneProduct ncbigene:4313
MAPK12 GeneProduct ncbigene:6300
MAP2K7 GeneProduct ncbigene:5609
MAPK14 GeneProduct ncbigene:1432
MAP2K3 GeneProduct ncbigene:5606
MAP3K5 GeneProduct ncbigene:4217
MAP2K4 GeneProduct ncbigene:6416
MAP2K6 GeneProduct ncbigene:5608
TNFRSF1A GeneProduct ncbigene:7132
TNF GeneProduct ncbigene:7124
FOS GeneProduct ncbigene:2353
TNF GeneProduct ncbigene:7124
CCNA2 GeneProduct ncbigene:890
CCNE1 GeneProduct ncbigene:898
EGFR GeneProduct ncbigene:1956
HBEGF GeneProduct ncbigene:1839
FGF7 GeneProduct ncbigene:2252
FASLG GeneProduct ncbigene:356
FAS GeneProduct ncbigene:355
RB1 GeneProduct ncbigene:5925
TP53 GeneProduct ncbigene:7157
CDKN1A GeneProduct ncbigene:1026
BCL2 GeneProduct ncbigene:596
BCL2L1 GeneProduct ncbigene:598
BCL2L11 GeneProduct ncbigene:10018
BCL3 GeneProduct ncbigene:602
CDKN2A GeneProduct ncbigene:1029
BID GeneProduct ncbigene:637
CFLAR GeneProduct ncbigene:8837
NFE2L2 GeneProduct ncbigene:4780
BAK1 GeneProduct ncbigene:578
BCL2L11 GeneProduct ncbigene:10018
BCL2L1 GeneProduct ncbigene:598
TP53 GeneProduct ncbigene:7157
BAX GeneProduct ncbigene:581
MCL1 GeneProduct ncbigene:4170
BCL2 GeneProduct ncbigene:596
BMF GeneProduct ncbigene:90427
ELK1 GeneProduct ncbigene:2002
JUN GeneProduct ncbigene:3725
ATF2 GeneProduct ncbigene:1386
MAPK8 GeneProduct ncbigene:5599


  1. Tumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategies. Broekgaarden M, Weijer R, van Gulik TM, Hamblin MR, Heger M. Cancer Metastasis Rev. 2015 Dec;34(4):643–90. PubMed Europe PMC Scholia
  2. Low-power photodynamic therapy induces survival signaling in perihilar cholangiocarcinoma cells. Weijer R, Broekgaarden M, van Golen RF, Bulle E, Nieuwenhuis E, Jongejan A, et al. BMC Cancer. 2015 Dec 26;15:1014. PubMed Europe PMC Scholia