Serotonin HTR1 group and FOS pathway (WP722)

Homo sapiens

This pathway depicts the downstream signaling of serotonin via the receptors 1 group, resulting in the production of FOS via ELK-SRF and CREB1. This pathway also shows the downstream signaling of serotonin via receptor 2A, resulting in the activation of STAT3.


Ruke Achoja , Kristina Hanspers , Alex Pico , Thomas Kelder , Andra Waagmeester , Egon Willighagen , Friederike Ehrhart , Eric Weitz , and Denise Slenter


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Homo sapiens



Pathway Ontology

serotonin signaling pathway


Label Type Compact URI Comment
1,2-Diacetin Metabolite cas:102-62-5 diacylglycerol
PtdIns3P Metabolite chebi:57836 phosphatidylinositol 3,4,5-triphosphate
1,4,5-Insp3 Metabolite cas:85166-31-0
CALCIUM Metabolite cas:7440-70-2
Serotonin Metabolite hmdb:HMDB0000259
PKC GeneProduct ncbigene:50818 protein kinase C
ELK1 GeneProduct ncbigene:2002 ELK1, member of ETS oncogene family
RASGRF1 GeneProduct ncbigene:5923 RAS protein-specific guanine nucleotide-releasing factor 1
MAP2K6 GeneProduct ncbigene:5608 mitogen activated protein kinase kinase 6
MAPK3 GeneProduct ncbigene:5595 mitogen activated protein kinase 3
PDPK1 GeneProduct ncbigene:5170 3-phosphoinositide dependent protein kinase-1
RASGRP1 GeneProduct ncbigene:10125 RAS guanyl releasing protein 1
RHOA GeneProduct ncbigene:387 ras homolog gene family, member A
RAP1A GeneProduct ncbigene:5906 RAS-related protein-1a
PI3K GeneProduct ncbigene:5290 phosphatidylinositol 3-kinase
RPS6KA5 GeneProduct ncbigene:9252 ribosomal protein S6 kinase, polypeptide 5
MAP2K1 GeneProduct ncbigene:5604 mitogen activated protein kinase kinase 1
SRF GeneProduct ncbigene:6722 serum response factor
ELK4 GeneProduct ncbigene:2005 ETS domain-containing protein Elk-4 (SRF accessory protein 1)
PLC GeneProduct eccode: phospholipase C
MAPKAPK3 GeneProduct ncbigene:7867 mitogen-activated protein kinase-activated protein kinase 3
CREB1 GeneProduct ncbigene:1385 cAMP response element-binding protein 1
BRAF GeneProduct ncbigene:673 v-raf murine sarcoma viral oncogene homolog B1
MAPKAPK2 GeneProduct ncbigene:9261 mitogen activated protein kinase 3
MAP2K2 GeneProduct ncbigene:5605 mitogen activated protein kinase kinase 2
MAPK14 GeneProduct ncbigene:1432 mitogen activated protein kinase 14
MAP3K1 GeneProduct ncbigene:4214 mitogen activated protein kinase kinase kinase 1
FOS GeneProduct ncbigene:2353 proto-oncogene protein c-fos
ITPR1 GeneProduct ncbigene:3708 inositol 1,4,5-triphosphate receptor 1
MAP2K3 GeneProduct ncbigene:5606 mitogen activated protein kinase kinase 3
MAPK1 GeneProduct hgnc.symbol:MAPK1 mitogen activated protein kinase 1
HTR2A GeneProduct ncbigene:3356 5-hydroxytryptamine (serotonin) receptor 2A
JAK2 GeneProduct ncbigene:3717 Janus kinase 2
GNAQ GeneProduct ncbigene:2776 guanine nucleotide binding protein, alpha q polypeptide
STAT3 GeneProduct ncbigene:6774 signal transducer and activator of transcription
GNAI1 Protein ncbigene:2770
GNAI2 Protein ncbigene:2771
HTR1D Protein ncbigene:3352
HTR1A Protein ncbigene:3350
HTR1B Protein ncbigene:3351
GNAO1 Protein ncbigene:2775
GNAI3 Protein ncbigene:2773
HTR1E Protein ncbigene:3354
HTR1F Protein ncbigene:3355


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