Glutathione and one-carbon metabolism (WP730)

Mus musculus

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This pathway provides a combined view on the one-carbon and glutathione metabolism pathways. Based on existing pathways:WP435,WP164

For a description of pathway objects, see the WikiPathways Legend.

Authors

Thomas Kelder , Lorraine Brennan , Martina Summer-Kutmon , Egon Willighagen , Alex Pico , Lauren J. Dupuis , Nhung Pham , Eric Weitz , and Kristina Hanspers

Activity

last edited

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Cited In

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

carbon fixation pathway classic metabolic pathway glutathione metabolic pathway

Participants

Label Type Compact URI Comment
5-Methyl Tetrahydrofolate Metabolite cas:134-35-0
Cysteinyl-glycine Metabolite kegg.compound:C01419
Homocysteine Metabolite cas:6027-13-0
Oxidized glutathione Metabolite kegg.compound:C00127
L-Amino acid Metabolite kegg.compound:C00151
Methionine Metabolite cas:63-68-3
NADPH Metabolite hmdb:HMDB0000221
S-adenosylhomocysteine Metabolite cas:979-92-0
Betaine Metabolite cas:107-43-7
L-Cysteine Metabolite kegg.compound:C00097
NADP+ Metabolite hmdb:HMDB0000217
L-Glutamate Metabolite kegg.compound:C00025
(5-L-Glutamyl)-L-amino acid Metabolite kegg.compound:C03740
Glycine Metabolite hmdb:HMDB0000123
Glutathione (reduced) Metabolite kegg.compound:C00051
Tetrahydrofolate Metabolite cas:135-16-0
g-L-Glutamyl-L-cysteine Metabolite kegg.compound:C00669
DMG Metabolite cas:107-43-7
5,10-Methylene Tetrahydrofolate Metabolite cas:25513-46-6
S-Adenosylmethionine Metabolite cas:29908-03-0
5-Oxoproline Metabolite kegg.compound:C01879
ANPEP GeneProduct ncbigene:16790
G6PD GeneProduct ncbigene:14381
1.11.1.12 GeneProduct eccode:1.11.1.12
GGTLA1 GeneProduct ncbigene:23887
GPX1 GeneProduct ncbigene:14775
BHMT GeneProduct ncbigene:12116
1.8.4.2 GeneProduct eccode:1.8.4.2
DNMT1 GeneProduct ncbigene:13433
MTRR GeneProduct ncbigene:210009
MTHFR GeneProduct ncbigene:17769
2.3.2.4 GeneProduct eccode:2.3.2.4
GCLM GeneProduct ncbigene:14630
GSR GeneProduct ncbigene:14782
1.8.4.4 GeneProduct eccode:1.8.4.4
GGT1 GeneProduct ncbigene:14598 (5-L-Glutamyl)-L-amino acid
GSS GeneProduct ncbigene:14854
GCLC GeneProduct ncbigene:14629
AMT GeneProduct ncbigene:434437 KEGG database: One carbon pool by folate - Homo sapiens (human)
KIAA0828 GeneProduct ncbigene:74340 KEGG Database Methionine metabolism - Homo sapiens (human)
MTR GeneProduct ncbigene:238505
MAT2B GeneProduct ncbigene:108645 KEGG Database Methionine metabolism - Homo sapiens (human)
3.4.11.4 GeneProduct eccode:3.4.11.4
1.8.4.7 GeneProduct eccode:1.8.4.7
1.8.3.3 GeneProduct eccode:1.8.3.3
1.8.5.1 GeneProduct eccode:1.8.5.1
DNMT3a GeneProduct ncbigene:13435 KEGG Database Methionine metabolism - Homo sapiens (human)
2.8.1.3 GeneProduct eccode:2.8.1.3
1.5.4.1 GeneProduct eccode:1.5.4.1
Chdh GeneProduct ncbigene:218865
GGT1 GeneProduct ncbigene:14598
GPX2 GeneProduct ncbigene:14776
DNMT3b GeneProduct ncbigene:13436 KEGG database: Methionine metabolism - Homo sapiens (human)
1.8.4.1 GeneProduct eccode:1.8.4.1
1.8.4.3 GeneProduct eccode:1.8.4.3
MAT1A GeneProduct ncbigene:11720 KEGG Database Methionine metabolism - Homo sapiens (human)
Oplah GeneProduct ncbigene:75475
1.1.1.43 GeneProduct eccode:1.1.1.43
IDH1 GeneProduct ncbigene:15926
AHCY GeneProduct ncbigene:269378 KEGG Database Methionine metabolism - Homo sapiens (human)
SHMT1 GeneProduct ncbigene:20425
GPX3 GeneProduct ncbigene:14778
SHMT2 GeneProduct ncbigene:108037 KEGG database: One carbon pool by folate - Homo sapiens (human)
GPX4 GeneProduct ncbigene:625249
CBS GeneProduct ncbigene:12411
CTH GeneProduct ncbigene:107869

References

  1. Twenty-four non-synonymous polymorphisms in the one-carbon metabolic pathway and risk of colorectal adenoma in the Nurses’ Health Study. Hazra A, Wu K, Kraft P, Fuchs CS, Giovannucci EL, Hunter DJ. Carcinogenesis. 2007 Jul;28(7):1510–9. PubMed Europe PMC Scholia