Focal adhesion (WP3197)

Bos taurus

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Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling. Source: KEGG http://www.genome.jp/kegg/pathway/hsa/hsa04510.html

Authors

Martina Summer-Kutmon and Eric Weitz

Activity

last edited

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

cell adhesion signaling pathway

Participants

Label Type Compact URI Comment
THBS4 GeneProduct ensembl:ENSBTAG00000012866 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7060
TNC GeneProduct ensembl:ENSBTAG00000000575 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3371
TNR GeneProduct ensembl:ENSBTAG00000011706 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7143
VTN GeneProduct ensembl:ENSBTAG00000016151 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7448
VWF GeneProduct ensembl:ENSBTAG00000012265 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7450
LAMC1 GeneProduct ensembl:ENSBTAG00000011966 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3915
TNN GeneProduct ensembl:ENSBTAG00000015650 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:63923
COL5A3 GeneProduct ensembl:ENSBTAG00000010179 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:50509
TNXB GeneProduct ensembl:ENSBTAG00000001444 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7148
COL4A6 GeneProduct ensembl:ENSBTAG00000013760 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1288
FIGF GeneProduct ensembl:ENSBTAG00000009476 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2277
HGF GeneProduct ensembl:ENSBTAG00000017664 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3082
IGF-I GeneProduct ensembl:ENSBTAG00000011082 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3479
PDGFA GeneProduct ensembl:ENSBTAG00000014541 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5154
PDGFB GeneProduct ensembl:ENSBTAG00000021697 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5155
PGF GeneProduct ensembl:ENSBTAG00000013688 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5228
PELO GeneProduct ensembl:ENSBTAG00000003268 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:53918
ITGA2 GeneProduct ensembl:ENSBTAG00000019289 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3673
ITGA3 GeneProduct ensembl:ENSBTAG00000019498 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3675
ITGA4 GeneProduct ensembl:ENSBTAG00000009256 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3676
ITGA5 GeneProduct ensembl:ENSBTAG00000013745 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3678
ITGA6 GeneProduct ensembl:ENSBTAG00000017266 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3655
ITGA7 GeneProduct ensembl:ENSBTAG00000012897 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3679
ITGA8 GeneProduct ensembl:ENSBTAG00000007602 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8516
ITGA9 GeneProduct ensembl:ENSBTAG00000016566 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3680
ITGA10 GeneProduct ensembl:ENSBTAG00000008373 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8515
ITGA11 GeneProduct ensembl:ENSBTAG00000008380 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:22801
ITGA2B GeneProduct ensembl:ENSBTAG00000008165 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3674
ITGAE GeneProduct ensembl:ENSBTAG00000015264 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3682
ITGAD GeneProduct ensembl:ENSBTAG00000019524 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3681
ITGAL GeneProduct ensembl:ENSBTAG00000007103 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3683
ITGAM GeneProduct ensembl:ENSBTAG00000047238 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3684
ITGAV GeneProduct ensembl:ENSBTAG00000019929 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3685
ITGB1 GeneProduct ensembl:ENSBTAG00000015910 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3688
ITGB2 GeneProduct ensembl:ENSBTAG00000017060 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3689
INTB3 GeneProduct ensembl:ENSBTAG00000009987 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3690
ITGB4 GeneProduct ensembl:ENSBTAG00000018169 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3691
ITGB5 GeneProduct ensembl:ENSBTAG00000013755 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3693
ITGB6 GeneProduct ensembl:ENSBTAG00000009080 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3694
ITGB8 GeneProduct ensembl:ENSBTAG00000003709 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3696
RAP1A GeneProduct ensembl:ENSBTAG00000014710 RAP1A; RAP1A member of RAS oncogene family
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5906
RAP1B GeneProduct ensembl:ENSBTAG00000008967 RAP1B; RAP1B member of RAS oncogene family
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5908
DOCK1 GeneProduct ensembl:ENSBTAG00000031890 DOCK1; dedicator of cyto-kinesis
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1793
SHC1 GeneProduct ensembl:ENSBTAG00000019838 SHC1; SHC (Src homology 2 domain containing) transforming protein 1
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6464
SHC3 GeneProduct ensembl:ENSBTAG00000011375 SHC3; neuronal Sh
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:53358
SOS1 GeneProduct ensembl:ENSBTAG00000011643 SOS1; son of sevenless homolog 1 (Drosophila)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6654
ZYX GeneProduct ensembl:ENSBTAG00000017970 ZYX; zyxin
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7791
CAV1 GeneProduct ensembl:ENSBTAG00000017869 CAV1; caveolin 1 caveolae protein 22kD
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:857
CAV3 GeneProduct ensembl:ENSBTAG00000022699 CAV3; caveolin 3
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:859
FYN GeneProduct ensembl:ENSBTAG00000011851 FYN; FYN oncogene related to SRC FGR YES [EC:2.7.1.112]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2534
GRB2 GeneProduct ensembl:ENSBTAG00000004736 GRB2; growth factor receptor-bound protein 2
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2885
VASP GeneProduct ensembl:ENSBTAG00000019604 VASP; vasodilator-stimulated phosphoprotein
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7408
SRC GeneProduct ensembl:ENSBTAG00000008938 SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714
ILK GeneProduct ensembl:ENSBTAG00000000696 ILK; integrin-linked kinase [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3611
CAV2 GeneProduct ensembl:ENSBTAG00000045584 CAV2; caveolin 2
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:858
ACTN1 GeneProduct ensembl:ENSBTAG00000018255 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:87
VCL GeneProduct ensembl:ENSBTAG00000021879 VCL; vinculin
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7414
CHAD GeneProduct ensembl:ENSBTAG00000021302 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1101
COL11A1 GeneProduct ensembl:ENSBTAG00000021217 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1301
COL11A2 GeneProduct ensembl:ENSBTAG00000000601 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1302
COL2A1 GeneProduct ensembl:ENSBTAG00000013155 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1280
COL3A1 GeneProduct ensembl:ENSBTAG00000021466 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1281
COL4A1 GeneProduct ensembl:ENSBTAG00000012849 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1282
COL4A2 GeneProduct ensembl:ENSBTAG00000025210 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1284
COL4A4 GeneProduct ensembl:ENSBTAG00000021310 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1286
COL5A1 GeneProduct ensembl:ENSBTAG00000047998 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1289
COL5A2 GeneProduct ensembl:ENSBTAG00000027020 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1290
COL6A2 GeneProduct ensembl:ENSBTAG00000019269 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1292
COL1A1 GeneProduct ensembl:ENSBTAG00000013103 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1277
COL1A2 GeneProduct ensembl:ENSBTAG00000013472 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1278
COMP GeneProduct ensembl:ENSBTAG00000004630 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1311
FN1 GeneProduct ensembl:ENSBTAG00000008300 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2335
IBSP GeneProduct ensembl:ENSBTAG00000000470 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3381
LAMA2 GeneProduct ensembl:ENSBTAG00000010229 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3908
LAMA3 GeneProduct ensembl:ENSBTAG00000027181 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3909
LAMA4 GeneProduct ensembl:ENSBTAG00000008817 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3910
LAMA5 GeneProduct ensembl:ENSBTAG00000003061 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3911
LAMB1 GeneProduct ensembl:ENSBTAG00000011412 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3912
LAMC1 GeneProduct ensembl:ENSBTAG00000022635 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3913
LAMC2 GeneProduct ensembl:ENSBTAG00000000793 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3918
RELN GeneProduct ensembl:ENSBTAG00000046817 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5649
SPP1 GeneProduct ensembl:ENSBTAG00000005260 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6696
THBS1 GeneProduct ensembl:ENSBTAG00000002006 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7057
THBS2 GeneProduct ensembl:ENSBTAG00000018810 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7058
THBS3 GeneProduct ensembl:ENSBTAG00000000057 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7059
LAMB3 GeneProduct ensembl:ENSBTAG00000016542 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3914
LAMA1 GeneProduct ensembl:ENSBTAG00000018160 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:284217
BLK GeneProduct ensembl:ENSBTAG00000005049 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:640
EGFR GeneProduct ensembl:ENSBTAG00000011628 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1956
ERBB2 GeneProduct ensembl:ENSBTAG00000021798 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2064
FGR GeneProduct ensembl:ENSBTAG00000011784 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2268
FLT1 GeneProduct ensembl:ENSBTAG00000016915 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2321
HCK GeneProduct ensembl:ENSBTAG00000007932 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3055
IGF1R GeneProduct ensembl:ENSBTAG00000021527 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3480
KDR GeneProduct ensembl:ENSBTAG00000000782 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3791
C-MET GeneProduct ensembl:ENSBTAG00000006161 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4233
PDGFRA GeneProduct ensembl:ENSBTAG00000007173 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5156
PDGFRB GeneProduct ensembl:ENSBTAG00000002804 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5159
PTK6 GeneProduct ensembl:ENSBTAG00000044091 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5753
SRMS GeneProduct ensembl:ENSBTAG00000001985 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6725
TXK GeneProduct ensembl:ENSBTAG00000005055 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7294
TESK2 GeneProduct ensembl:ENSBTAG00000011244 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10420
STYK1 GeneProduct ensembl:ENSBTAG00000015351 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55359
TNK2 GeneProduct ensembl:ENSBTAG00000021364 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10188
TNK1 GeneProduct ensembl:ENSBTAG00000017739 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8711
ARAF GeneProduct ensembl:ENSBTAG00000005039 ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:369
BRAF GeneProduct ensembl:ENSBTAG00000021761 BRAF; v-raf murine sarcoma viral oncogene homolog B1 [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:673
RAF1 GeneProduct ensembl:ENSBTAG00000045748 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894
MAPK4 GeneProduct ensembl:ENSBTAG00000009907 MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5596
MAPK7 GeneProduct ensembl:ENSBTAG00000001014 MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5598
MAP2K5 GeneProduct ensembl:ENSBTAG00000000218 MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5607
MAP2K6 GeneProduct ensembl:ENSBTAG00000001609 MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5608
MAPK12 GeneProduct ensembl:ENSBTAG00000019574 MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6300
MAPK1 GeneProduct ensembl:ENSBTAG00000010312 MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MAPK6 GeneProduct ensembl:ENSBTAG00000005865 MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5597
MAP2K2 GeneProduct ensembl:ENSBTAG00000024450 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605
MAP2K3 GeneProduct ensembl:ENSBTAG00000010576 MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5606
MAP2K1 GeneProduct ensembl:ENSBTAG00000033983 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
PTK2 GeneProduct ensembl:ENSBTAG00000009578 PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5747
ARHGAP5 GeneProduct ensembl:ENSBTAG00000027024 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:394
RHOB GeneProduct ensembl:ENSBTAG00000046054 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:388
FLNA GeneProduct ensembl:ENSBTAG00000011190 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2316
TLN1 GeneProduct ensembl:ENSBTAG00000025868 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7094
PXN GeneProduct ensembl:ENSBTAG00000018108 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5829
CAPN1 GeneProduct ensembl:ENSBTAG00000010230 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:823
RHOA GeneProduct ensembl:ENSBTAG00000004279 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:387
PDPK1 GeneProduct ensembl:ENSBTAG00000034436 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5170
PARVB GeneProduct ensembl:ENSBTAG00000021978 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:29780
AKT1 GeneProduct ensembl:ENSBTAG00000017636 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207
AKT2 GeneProduct ensembl:ENSBTAG00000001400 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:208
AKT3 GeneProduct ensembl:ENSBTAG00000017788 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10000
ROCK1 GeneProduct ensembl:ENSBTAG00000008403 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6093
ROCK2 GeneProduct ensembl:ENSBTAG00000005847 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9475
PIP5K1C GeneProduct ensembl:ENSBTAG00000000710 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23396
PPP1R12A GeneProduct ensembl:ENSBTAG00000014609 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4659
MYL6 GeneProduct ensembl:ENSBTAG00000010799 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4637
MYLK GeneProduct ensembl:ENSBTAG00000014567 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4638
MYLK2 GeneProduct ensembl:ENSBTAG00000014930 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:85366
ACTB GeneProduct ensembl:ENSBTAG00000026199 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:60
ACTG1 GeneProduct ensembl:ENSBTAG00000006189 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:71
GSK3B GeneProduct ensembl:ENSBTAG00000048057 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2932
PIK3CA GeneProduct ensembl:ENSBTAG00000009232 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5290
PIK3CD GeneProduct ensembl:ENSBTAG00000018984 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5293
PIK3R1 GeneProduct ensembl:ENSBTAG00000010989 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5295
PIK3CG GeneProduct ensembl:ENSBTAG00000020848 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5294
PIK3R5 GeneProduct ensembl:ENSBTAG00000005978 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23533
PIK3R4 GeneProduct ensembl:ENSBTAG00000020787 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:30849
PIK3CB GeneProduct ensembl:ENSBTAG00000006909 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5291
PTEN GeneProduct ensembl:ENSBTAG00000009498 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5728
VAV1 GeneProduct ensembl:ENSBTAG00000039160 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7409
RAC1 GeneProduct ensembl:ENSBTAG00000009233 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5879
RAC2 GeneProduct ensembl:ENSBTAG00000011043 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5880
RAC3 GeneProduct ensembl:ENSBTAG00000022927 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5881
PAK1 GeneProduct ensembl:ENSBTAG00000010191 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5058
PAK3 GeneProduct ensembl:ENSBTAG00000015670 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5063
PAK2 GeneProduct ensembl:ENSBTAG00000047856 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5062
PAK4 GeneProduct ensembl:ENSBTAG00000013958 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10298
PAK7 GeneProduct ensembl:ENSBTAG00000017679 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57144
PAK6 GeneProduct ensembl:ENSBTAG00000019076 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:56924
ELK1 GeneProduct ensembl:ENSBTAG00000015817 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2002
PDGFC GeneProduct ensembl:ENSBTAG00000043959 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:56034
PDGFD GeneProduct ensembl:ENSBTAG00000034827 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:80310
VEGFA GeneProduct ensembl:ENSBTAG00000047561 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7422
VEGFB GeneProduct ensembl:ENSBTAG00000047567 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7423
VEGFC GeneProduct ensembl:ENSBTAG00000014737 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7424
BCAR1 GeneProduct ensembl:ENSBTAG00000012002 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9564
CRK GeneProduct ensembl:ENSBTAG00000005665 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1398
RAPGEF1 GeneProduct ensembl:ENSBTAG00000020791 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2889
CDC42 GeneProduct ensembl:ENSBTAG00000001700 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:998
BRAF GeneProduct ensembl:ENSBTAG00000021761 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:673
BAD GeneProduct ensembl:ENSBTAG00000012511 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:572
BCL2 GeneProduct ensembl:ENSBTAG00000019302 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:596
BIRC2 GeneProduct ensembl:ENSBTAG00000035735 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:329
BIRC3 GeneProduct ensembl:ENSBTAG00000024918 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:330
MAPK8 GeneProduct ensembl:ENSBTAG00000007876 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5599
MAPK9 GeneProduct ensembl:ENSBTAG00000004709 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5601
JUN GeneProduct ensembl:ENSBTAG00000004037 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725
CCND1 GeneProduct ensembl:ENSBTAG00000017514 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:595
CCND2 GeneProduct ensembl:ENSBTAG00000016649 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:894
CCND3 GeneProduct ensembl:ENSBTAG00000010106 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:896
ITGB7 GeneProduct ensembl:ENSBTAG00000018993 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3695
HRAS GeneProduct ensembl:ENSBTAG00000046644 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265
CTNNB1 GeneProduct ensembl:ENSBTAG00000016420 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1499
DIAPH1 GeneProduct ensembl:ENSBTAG00000030499 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1729

References

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  3. Paxillin and focal adhesion signalling. Turner CE. Nat Cell Biol. 2000 Dec;2(12):E231-6. PubMed Europe PMC Scholia
  4. Focal adhesions: structure and dynamics. Petit V, Thiery JP. Biol Cell. 2000 Oct;92(7):477–94. PubMed Europe PMC Scholia
  5. Fibronectin, integrins, and growth control. Danen EH, Yamada KM. J Cell Physiol. 2001 Oct;189(1):1–13. PubMed Europe PMC Scholia
  6. The protein kinase B/Akt signalling pathway in human malignancy. Nicholson KM, Anderson NG. Cell Signal. 2002 May;14(5):381–95. PubMed Europe PMC Scholia
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