Aryl hydrocarbon receptor pathway (WP2586)

Homo sapiens

The Aryl Hydrocarbon receptor (AhR) is ligand activated transcription factor that regulates wide spectrum of gene expression. The main mediator of AhR is 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) or polycyclic aromatic hydrocarbons which are widespread environmental pollutant causing a variety of severe health effects, e.g. immunosuppression, carcinogenesis and hepatotoxicity. AhR is a member of basic helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. In the absence of ligand, the AhR can be found in the cytosol, bound to a dimer of the heat shock protein of 90 kDa (Hsp90) and the immunophilin-like protein, AIP (also known as XAP2 and ARA9). Upon ligand binding, the AHR translocates to the nucleus and binds with ARNT. The AHR/ARNT heterodimer binds to xenobiotic response elements and regulates a diverse set of genes. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Prakamya Gupta , Alex Pico , Martina Summer-Kutmon , Zahra Roudbari , Egon Willighagen , Marianthi Kalafati , Denise Slenter , Kristina Hanspers , and Eric Weitz


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Homo sapiens



Pathway Ontology

regulatory pathway


Label Type Compact URI Comment
TCDD Metabolite chebi:28119
PAH Metabolite chebi:33848
TCDD Metabolite chebi:28119
PAH Metabolite chebi:33848
KLF6 GeneProduct ncbigene:1316
VEGFA GeneProduct ncbigene:7422
CCL1 GeneProduct ncbigene:6346 PMID: 16679317 PAHs induce expression of the chemokine CCL1 in an AhR- and calcium-dependent manner.
CDKN1B GeneProduct ncbigene:1027
ARNT GeneProduct ncbigene:405
AIP GeneProduct ensembl:ENSG00000110711
CYP1A1 GeneProduct ncbigene:1543
EGFR GeneProduct ncbigene:1956
AIP GeneProduct ensembl:ENSG00000110711
AHR GeneProduct ncbigene:196
P23 GeneProduct ensembl:ENSG00000110711
AHR GeneProduct ncbigene:196
AHR GeneProduct ncbigene:196
HSP90AA1 GeneProduct ncbigene:3320
HSP90AA1 GeneProduct ncbigene:3320
TNF GeneProduct ncbigene:7124
CDC37 GeneProduct ncbigene:11140
RAF1 GeneProduct ensembl:ENSG00000132155
MAP2K1 GeneProduct ensembl:ENSG00000169032
PTGS2 GeneProduct ncbigene:5743
PSRC1 GeneProduct ncbigene:84722
RELA GeneProduct ncbigene:5970
NFKB1 GeneProduct ncbigene:4790
RELA GeneProduct ncbigene:5970
NFKB1 GeneProduct ncbigene:4790
PSRC1 GeneProduct ncbigene:84722
CD36 GeneProduct ncbigene:948
NFE2L2 GeneProduct ncbigene:4780
CYP1A2 GeneProduct ncbigene:1544
CYP1B1 GeneProduct ncbigene:1545
CDKN1A GeneProduct ncbigene:1026
CDK2 GeneProduct ncbigene:1017
RB1 GeneProduct ncbigene:5925
E2F1 GeneProduct ncbigene:1869
AHRR GeneProduct ncbigene:57491
NRAS GeneProduct ensembl:ENSG00000213281
HRAS GeneProduct ensembl:ENSG00000174775
KRAS GeneProduct ensembl:ENSG00000133703
HSP90AA1 GeneProduct ncbigene:3320
NQO1 Protein ncbigene:1728
HSP90AA1 Protein ncbigene:3320
ESR1 Protein ncbigene:2099 Estrogen Receptor
Calcium channel Protein wikidata:Q15322916
EP300 Protein ncbigene:2033
pRb Protein uniprot:P06400
EBNA-3 Protein ncbigene:17494212
ZAC1 Protein ncbigene:5325
RET Protein ncbigene:5979
MYC Protein ncbigene:4609
SRC Protein ncbigene:6714
MAPK1 Protein ncbigene:5594
EP300 Protein ncbigene:2033
NCOA7 Protein ncbigene:135112 Official Symbol= NCOA7
NRIP1 Protein ncbigene:8204
CYP1A1 Protein ncbigene:1543
LPL Protein ncbigene:4023 lipoprotein lipase
FGF21 Protein ncbigene:26291
HPGDS Protein ncbigene:27306
GCLC Protein ncbigene:2729
NRIP1 Protein ncbigene:8204
NF1 Protein ncbigene:4763
NCOA7 Protein ncbigene:135112
NCOR2 Protein ncbigene:9612
EP300 Protein ncbigene:2033


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