IL19 signaling (WP5422)

Homo sapiens

Schematic representation of IL-19 signaling pathway

Authors

Rex D A B , Isabel Wassink , Egon Willighagen , Kristina Hanspers , Javier Millán Acosta , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

Interleukin mediated signaling pathway signaling pathway interleukin-19 signaling pathway

Participants

Label Type Compact URI Comment
SOCS1 GeneProduct ncbigene:8651
SOCS5 GeneProduct ncbigene:9655
IL19 GeneProduct ncbigene:29949
Stat3 Protein ncbigene:20848
IL19 Protein ncbigene:29949
JAK1 Protein ncbigene:3716
STAT3 Protein ncbigene:6774
IL19 Protein ncbiprotein:29949
MAPK3 Protein ncbigene:5595
MAPK1 Protein ncbigene:5594
STAT3 Protein ncbigene:6774
STAT1 Protein ncbigene:6772
RAC1 Protein ncbigene:5879
IL20RB Protein ncbigene:53833
NFKB1 Protein ncbigene:4790
CCNB1 Protein ncbigene:891
AKT1 Protein ncbigene:207
TGFB1 Protein ncbigene:7040
MAPK8 Protein ncbigene:5599
CXCR4 Protein ncbigene:7852
MMP1 Protein ncbigene:4312
Akt1 Protein ncbigene:11651
Mapk8 Protein ncbigene:26419
Mapk14 Protein ncbigene:26416
Tgfb1 Protein ncbigene:7040
Casp3 Protein ncbigene:12367
Casp9 Protein ncbigene:12371
Ccl2 Protein ncbigene:20296
TNFA Protein ncbigene:7124
IL10 Protein ncbigene:16176
MUC5AC Protein ncbigene:4586
TGFB1 Protein ncbigene:21803
ACTA2 Protein ncbigene:59
IL20RA Protein ncbigene:53832
MAPK14 Protein ncbigene:1432
IL4 Protein ncbigene:3565
IL4R Protein ncbigene:3566
TNFR Protein ncbigene:7132
CCL11 Protein ncbigene:6356
STAT6 Protein ncbigene:6778
IL13 Protein ncbigene:29949
IL13R Protein ncbigene:53832
IL17R Protein ncbigene:53832
IL17 Protein ncbigene:29949
SMAD3 Protein ncbigene:20848
SOCS5 Protein ncbigene:9655
COL1A1 Protein ncbigene:1277
Mapk3 Protein ncbigene:26417
Mapk1 Protein ncbigene:26413
TNFA Protein ncbigene:29949
TGFBR1 Protein ncbigene:21803
TGFBR2 Protein ncbigene:21803
IL1B Protein ncbigene:16176

References

  1. A2B adenosine receptors induce IL-19 from bronchial epithelial cells, resulting in TNF-alpha increase. Zhong H, Wu Y, Belardinelli L, Zeng D. Am J Respir Cell Mol Biol. 2006 Nov;35(5):587–92. PubMed Europe PMC Scholia
  2. Expression and suppressive effects of interleukin-19 on vascular smooth muscle cell pathophysiology and development of intimal hyperplasia. Tian Y, Sommerville LJ, Cuneo A, Kelemen SE, Autieri MV. Am J Pathol. 2008 Sep;173(3):901–9. PubMed Europe PMC Scholia
  3. The anti-inflammatory cytokine interleukin 19 is expressed by and angiogenic for human endothelial cells. Jain S, Gabunia K, Kelemen SE, Panetti TS, Autieri MV. Arterioscler Thromb Vasc Biol. 2011 Jan;31(1):167–75. PubMed Europe PMC Scholia
  4. Interleukin-19 downregulates interleukin-4-induced eotaxin production in human nasal fibroblasts. Higashino M, Takabayashi T, Takahashi N, Okamoto M, Narita N, Kojima A, et al. Allergol Int. 2011 Dec;60(4):449–57. PubMed Europe PMC Scholia
  5. Interleukin-19 mediates tissue damage in murine ischemic acute kidney injury. Hsu YH, Li HH, Sung JM, Chen WT, Hou YC, Chang MS. PLoS One. 2013;8(2):e56028. PubMed Europe PMC Scholia
  6. Inhibiting interleukin-19 activity ameliorates esophageal squamous cell carcinoma progression. Hsing CH, Kwok FA, Cheng HC, Li CF, Chang MS. PLoS One. 2013 Oct 9;8(10):e75254. PubMed Europe PMC Scholia
  7. Interleukin-19 is cardioprotective in dominant negative cyclic adenosine monophosphate response-element binding protein-mediated heart failure in a sex-specific manner. Bruns DR, Ghincea AR, Ghincea CV, Azuma YT, Watson PA, Autieri MV, et al. World J Cardiol. 2017 Aug 26;9(8):673–84. PubMed Europe PMC Scholia
  8. Analysis of interleukin-20 receptor complexes in trabecular meshwork cells and effects of cytokine signaling in anterior segment perfusion culture. Keller KE, Yang YF, Sun YY, Walter MR, Wirtz MK. Mol Vis. 2019 Apr 27;25:266–82. PubMed Europe PMC Scholia
  9. IL-19 Up-Regulates Mucin 5AC Production in Patients With Chronic Rhinosinusitis via STAT3 Pathway. Lai X, Li X, Chang L, Chen X, Huang Z, Bao H, et al. Front Immunol. 2019 Jul 17;10:1682. PubMed Europe PMC Scholia
  10. Osteocytes regulate neutrophil development through IL-19: a potent cytokine for neutropenia treatment. Xiao M, Zhang W, Liu W, Mao L, Yang J, Hu L, et al. Blood. 2021 Jun 24;137(25):3533–47. PubMed Europe PMC Scholia
  11. IL-19 induced by IL-13/IL-17A in the nasal epithelium of patients with chronic rhinosinusitis upregulates MMP-9 expression via ERK/NF-κB signaling pathway. Li X, Huang J, Chen X, Lai X, Huang Z, Li Y, et al. Clin Transl Allergy. 2021 Mar;11(1):e12003. PubMed Europe PMC Scholia
  12. Interleukin-19 Aggravates Pulmonary Fibrosis via Activating Fibroblast through TGF-β/Smad Pathway. Wang Y, Sun S, Wang K, Zhang M, Li M, Zan Y, et al. Mediators Inflamm. 2022 Mar 3;2022:6755407. PubMed Europe PMC Scholia
  13. IL-20RB mediates tumoral response to osteoclastic niches and promotes bone metastasis of lung cancer. He Y, Luo W, Liu Y, Wang Y, Ma C, Wu Q, et al. J Clin Invest. 2022 Oct 17;132(20):e157917. PubMed Europe PMC Scholia