IL-19 signaling pathway (WP5422)

Homo sapiens

Authors

Rex D A B , Isabel Wassink , Egon Willighagen , Kristina Hanspers , Javier Millán Acosta , and Eric Weitz

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

signaling pathway Interleukin mediated signaling pathway interleukin-19 signaling pathway

References

1. A2B adenosine receptors induce IL-19 from bronchial epithelial cells, resulting in TNF-alpha increase. Zhong H, Wu Y, Belardinelli L, Zeng D. Am J Respir Cell Mol Biol. 2006 Nov;35(5):587–92. PubMed Europe PMC Scholia
2. Expression and suppressive effects of interleukin-19 on vascular smooth muscle cell pathophysiology and development of intimal hyperplasia. Tian Y, Sommerville LJ, Cuneo A, Kelemen SE, Autieri MV. Am J Pathol. 2008 Sep;173(3):901–9. PubMed Europe PMC Scholia
3. The anti-inflammatory cytokine interleukin 19 is expressed by and angiogenic for human endothelial cells. Jain S, Gabunia K, Kelemen SE, Panetti TS, Autieri MV. Arterioscler Thromb Vasc Biol. 2011 Jan;31(1):167–75. PubMed Europe PMC Scholia
4. Interleukin-19 downregulates interleukin-4-induced eotaxin production in human nasal fibroblasts. Higashino M, Takabayashi T, Takahashi N, Okamoto M, Narita N, Kojima A, et al. Allergol Int. 2011 Dec;60(4):449–57. PubMed Europe PMC Scholia
5. Interleukin-19 mediates tissue damage in murine ischemic acute kidney injury. Hsu YH, Li HH, Sung JM, Chen WT, Hou YC, Chang MS. PLoS One. 2013;8(2):e56028. PubMed Europe PMC Scholia
6. Inhibiting interleukin-19 activity ameliorates esophageal squamous cell carcinoma progression. Hsing CH, Kwok FA, Cheng HC, Li CF, Chang MS. PLoS One. 2013 Oct 9;8(10):e75254. PubMed Europe PMC Scholia
7. Interleukin-19 is cardioprotective in dominant negative cyclic adenosine monophosphate response-element binding protein-mediated heart failure in a sex-specific manner. Bruns DR, Ghincea AR, Ghincea CV, Azuma YT, Watson PA, Autieri MV, et al. World J Cardiol. 2017 Aug 26;9(8):673–84. PubMed Europe PMC Scholia
8. Analysis of interleukin-20 receptor complexes in trabecular meshwork cells and effects of cytokine signaling in anterior segment perfusion culture. Keller KE, Yang YF, Sun YY, Walter MR, Wirtz MK. Mol Vis. 2019 Apr 27;25:266–82. PubMed Europe PMC Scholia
9. IL-19 Up-Regulates Mucin 5AC Production in Patients With Chronic Rhinosinusitis via STAT3 Pathway. Lai X, Li X, Chang L, Chen X, Huang Z, Bao H, et al. Front Immunol. 2019 Jul 17;10:1682. PubMed Europe PMC Scholia
10. Osteocytes regulate neutrophil development through IL-19: a potent cytokine for neutropenia treatment. Xiao M, Zhang W, Liu W, Mao L, Yang J, Hu L, et al. Blood. 2021 Jun 24;137(25):3533–47. PubMed Europe PMC Scholia
11. IL-19 induced by IL-13/IL-17A in the nasal epithelium of patients with chronic rhinosinusitis upregulates MMP-9 expression via ERK/NF-κB signaling pathway. Li X, Huang J, Chen X, Lai X, Huang Z, Li Y, et al. Clin Transl Allergy. 2021 Mar;11(1):e12003. PubMed Europe PMC Scholia
12. Interleukin-19 Aggravates Pulmonary Fibrosis via Activating Fibroblast through TGF-β/Smad Pathway. Wang Y, Sun S, Wang K, Zhang M, Li M, Zan Y, et al. Mediators Inflamm. 2022 Mar 3;2022:6755407. PubMed Europe PMC Scholia
13. IL-20RB mediates tumoral response to osteoclastic niches and promotes bone metastasis of lung cancer. He Y, Luo W, Liu Y, Wang Y, Ma C, Wu Q, et al. J Clin Invest. 2022 Oct 17;132(20):e157917. PubMed Europe PMC Scholia