SARS-CoV-2 altering angiogenesis via NRP1 (WP5065)

Homo sapiens

Mechanism of how the SARS-cov-2 virus is involved in altering angiogenesis and how NRP1 might play a role as an entry factor for the virus.


Simon Vossen , Friederike Ehrhart , Lena Szabo , Eric Weitz , and Nhung Pham


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Homo sapiens




Disease Ontology

COVID-19 severe acute respiratory syndrome

Pathway Ontology

disease pathway


Label Type Compact URI Comment
FURIN GeneProduct ensembl:ENSG00000140564
NRP1 GeneProduct ensembl:ENSG00000099250
KDR GeneProduct ensembl:ENSG00000128052
ACE2 GeneProduct ensembl:ENSG00000130234
VEGFA GeneProduct ensembl:ENSG00000112715
NRP1 GeneProduct ensembl:ENSG00000099250
S2 Protein wikidata:Q106020384
Surface glycoprotein S Protein uniprot:P0DTC2
S1 Protein wikidata:Q106020256


  1. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M. Cell. 1998 Mar 20;92(6):735–45. PubMed Europe PMC Scholia
  2. SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce analgesia. Moutal A, Martin LF, Boinon L, Gomez K, Ran D, Zhou Y, et al. bioRxiv. 2020 Sep 14;2020.07.17.209288. PubMed Europe PMC Scholia
  3. Neuropilin-1 is a host factor for SARS-CoV-2 infection. Daly JL, Simonetti B, Klein K, Chen KE, Williamson MK, Antón-Plágaro C, et al. Science. 2020 Nov 13;370(6518):861–5. PubMed Europe PMC Scholia
  4. The role of Neuropilin-1 in COVID-19. Mayi BS, Leibowitz JA, Woods AT, Ammon KA, Liu AE, Raja A. PLoS Pathog. 2021 Jan 4;17(1):e1009153. PubMed Europe PMC Scholia
  5. Neuropilin-1 Assists SARS-CoV-2 Infection by Stimulating the Separation of Spike Protein Domains S1 and S2. Li ZL, Buck M. bioRxiv. 2021 Jan 19;2021.01.06.425627. PubMed Europe PMC Scholia
  6. Neurobiology of SARS-CoV-2 interactions with the peripheral nervous system: implications for COVID-19 and pain. McFarland AJ, Yousuf MS, Shiers S, Price TJ. Pain Rep. 2021 Jan 7;6(1):e885. PubMed Europe PMC Scholia