SARS-CoV-2 altering angiogenesis via NRP1 (WP5065)

Homo sapiens

Mechanism of how the SARS-cov-2 virus is involved in altering angiogenesis and how NRP1 might play a role as an entry factor for the virus.

Authors

Simon Vossen , Friederike Ehrhart , Lena Szabo , Eric Weitz , and Nhung Pham

Activity

last edited

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Organisms

Homo sapiens

Communities

COVID-19

Annotations

Disease Ontology

COVID-19 severe acute respiratory syndrome

Pathway Ontology

disease pathway

Participants

Label Type Compact URI Comment
FURIN GeneProduct ensembl:ENSG00000140564
NRP1 GeneProduct ensembl:ENSG00000099250
KDR GeneProduct ensembl:ENSG00000128052
ACE2 GeneProduct ensembl:ENSG00000130234
VEGFA GeneProduct ensembl:ENSG00000112715
NRP1 GeneProduct ensembl:ENSG00000099250
S2 Protein wikidata:Q106020384
Surface glycoprotein S Protein uniprot:P0DTC2
S1 Protein wikidata:Q106020256

References

  1. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M. Cell. 1998 Mar 20;92(6):735–45. PubMed Europe PMC Scholia
  2. SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce analgesia. Moutal A, Martin LF, Boinon L, Gomez K, Ran D, Zhou Y, et al. bioRxiv. 2020 Sep 14;2020.07.17.209288. PubMed Europe PMC Scholia
  3. Neuropilin-1 is a host factor for SARS-CoV-2 infection. Daly JL, Simonetti B, Klein K, Chen KE, Williamson MK, Antón-Plágaro C, et al. Science. 2020 Nov 13;370(6518):861–5. PubMed Europe PMC Scholia
  4. The role of Neuropilin-1 in COVID-19. Mayi BS, Leibowitz JA, Woods AT, Ammon KA, Liu AE, Raja A. PLoS Pathog. 2021 Jan 4;17(1):e1009153. PubMed Europe PMC Scholia
  5. Neuropilin-1 Assists SARS-CoV-2 Infection by Stimulating the Separation of Spike Protein Domains S1 and S2. Li ZL, Buck M. bioRxiv. 2021 Jan 19;2021.01.06.425627. PubMed Europe PMC Scholia
  6. Neurobiology of SARS-CoV-2 interactions with the peripheral nervous system: implications for COVID-19 and pain. McFarland AJ, Yousuf MS, Shiers S, Price TJ. Pain Rep. 2021 Jan 7;6(1):e885. PubMed Europe PMC Scholia