T cell modulation in pancreatic cancer (WP5078)

Homo sapiens

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T cells are important effector cells in pancreatic cancer. Their function is inhibited by various cellular interactions and secreted factors in the tumor microenvironment (TME). Both immune cells and pancreatic cancer cells are able to modulate T cell activation.

Authors

Dana Mustafa , Martina Summer-Kutmon , Eric Weitz , and Isabel Wassink

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Diseases PancCanNet

Annotations

Disease Ontology

pancreatic cancer

Cell Type Ontology

pancreatic stellate cell professional antigen presenting cell malignant cell myeloid suppressor cell T cell CD8-positive, alpha-beta T cell

Pathway Ontology

immune response pathway pancreatic cancer pathway disease pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Adenosine Metabolite chebi:16335
Adenine Metabolite chebi:16708
Urea Metabolite chebi:16199
L-ornithine Metabolite chebi:15729
L-arginine Metabolite chebi:29016
PGE2 Metabolite chebi:15551
D-tryptophan Metabolite chebi:57719
Kynurenine Metabolite chebi:28683
L-tryptophan Metabolite chebi:57912
ICOS Protein uniprot:Q9Y6W8
CD226 Protein uniprot:Q15762
FASLG Protein uniprot:P48023
HAVCR2 Protein uniprot:Q8TDQ0
TRBC1 Protein ensembl:ENSG00000211751 P01850 - UniProt identifier
Type your comment here
IL6 Protein uniprot:P05231
CCL17 Protein uniprot:Q92583
LGALS9 Protein uniprot:O00182
B2M Protein uniprot:P61769
FAS Protein uniprot:P25445
CXCL12 Protein uniprot:P48061
ARG1 Protein uniprot:P05089
PVR Protein uniprot:P15151
CCL22 Protein uniprot:O00626
TNFRSF4 Protein uniprot:P43489
VSIR Protein uniprot:Q9H7M9
TIGIT Protein uniprot:Q495A1
CD274 Protein uniprot:Q9NZQ7
VEGFA Protein uniprot:P15692
VEGFC Protein uniprot:P49767
FAP Protein uniprot:Q12884
VTCN1 Protein uniprot:Q7Z7D3
CD276 Protein uniprot:Q5ZPR3
CD40 Protein uniprot:P25942
IL10 Protein uniprot:P22301
LGALS3 Protein uniprot:P17931
TNFRSF9 Protein uniprot:Q07011
PDCD1 Protein uniprot:Q15116
HLA-A Protein uniprot:P04439
FAP Protein uniprot:Q12884
LGALS1 Protein uniprot:P09382
TRAC Protein ensembl:ENSG00000277734 P01848 - UniProt identifier
Type your comment here
PGF Protein uniprot:P49763
TGFB1 Protein ensembl:ENSG00000105329 P01137 - UniProt identifier
Type your comment here
TGFB3 Protein uniprot:P10600
IDO1 Protein uniprot:P14902
CD40LG Protein uniprot:P29965
CD28 Protein uniprot:P10747
TGFB2 Protein uniprot:P61812
VEGFD Protein uniprot:O43915
CTLA4 Protein uniprot:P16410
VEGFB Protein uniprot:P49765
CD274 Protein uniprot:Q9NZQ7
CD86 Protein uniprot:P42081
PDCD1LG2 Protein uniprot:Q9BQ51
CD80 Protein uniprot:P33681
TNFSF9 Protein uniprot:P41273
TNFSF4 Protein uniprot:P23510
PDCD1 Protein uniprot:Q15116
PDCD1 Protein uniprot:Q15116
CD274 Protein uniprot:Q9NZQ7
TGFB2 Protein uniprot:P61812
TGFB1 Protein ensembl:ENSG00000105329 P01137 - UniProt identifier
Type your comment here
TGFB3 Protein uniprot:P10600
IL10 Protein uniprot:P22301
TGFB1 Protein ensembl:ENSG00000105329 P01137 - UniProt identifier
Type your comment here
TGFB2 Protein uniprot:P61812
TGFB3 Protein uniprot:P10600
IL10 Protein uniprot:P22301
LGALS1 Protein uniprot:P09382
ENTPD1 Protein uniprot:P49961
NT5E Protein uniprot:P21589
ARG1 Protein uniprot:P05089

References

  1. Role of the immune system in pancreatic cancer progression and immune modulating treatment strategies. Sideras K, Braat H, Kwekkeboom J, van Eijck CH, Peppelenbosch MP, Sleijfer S, et al. Cancer Treat Rev. 2014 May;40(4):513–22. PubMed Europe PMC Scholia
  2. Metabolic Interactions in the Tumor Microenvironment. Lyssiotis CA, Kimmelman AC. Trends Cell Biol. 2017 Nov;27(11):863–75. PubMed Europe PMC Scholia
  3. Functions of pancreatic stellate cell-derived soluble factors in the microenvironment of pancreatic ductal carcinoma. Wu Q, Tian Y, Zhang J, Zhang H, Gu F, Lu Y, et al. Oncotarget. 2017 Oct 19;8(60):102721–38. PubMed Europe PMC Scholia
  4. Tumor microenvironment participates in metastasis of pancreatic cancer. Ren B, Cui M, Yang G, Wang H, Feng M, You L, et al. Mol Cancer. 2018 Jul 30;17(1):108. PubMed Europe PMC Scholia
  5. The reciprocal regulation between host tissue and immune cells in pancreatic ductal adenocarcinoma: new insights and therapeutic implications. Liu X, Xu J, Zhang B, Liu J, Liang C, Meng Q, et al. Mol Cancer. 2019 Dec 13;18(1):184. PubMed Europe PMC Scholia
  6. Mechanisms of T-Cell Exhaustion in Pancreatic Cancer. Saka D, Gökalp M, Piyade B, Cevik NC, Arik Sever E, Unutmaz D, et al. Cancers (Basel). 2020 Aug 14;12(8):2274. PubMed Europe PMC Scholia
  7. Prognostic significance and therapeutic potential of the immune checkpoint VISTA in pancreatic cancer. Hou Z, Pan Y, Fei Q, Lin Y, Zhou Y, Liu Y, et al. J Cancer Res Clin Oncol. 2021 Feb;147(2):517–31. PubMed Europe PMC Scholia
  8. Arginine metabolism: a potential target in pancreatic cancer therapy. Yang JS, Wang CC, Qiu JD, Ren B, You L. Chin Med J (Engl). 2020 Nov 4;134(1):28–37. PubMed Europe PMC Scholia
  9. T cells in pancreatic cancer stroma. Goulart MR, Stasinos K, Fincham REA, Delvecchio FR, Kocher HM. World J Gastroenterol. 2021 Dec 14;27(46):7956–68. PubMed Europe PMC Scholia
  10. Role of CD155/TIGIT in Digestive Cancers: Promising Cancer Target for Immunotherapy. Wang D, Gu Y, Yan X, Huo C, Wang G, Zhao Y, et al. Front Oncol. 2022 Mar 30;12:844260. PubMed Europe PMC Scholia
  11. ICOS is upregulated on T cells following radiation and agonism combined with radiation results in enhanced tumor control. Blair T, Baird J, Bambina S, Kramer G, Gostissa M, Harvey CJ, et al. Sci Rep. 2022 Sep 2;12(1):14954. PubMed Europe PMC Scholia