T cells are important effector cells in pancreatic cancer. Their function is inhibited by various cellular interactions and secreted factors in the tumor microenvironment (TME). Both immune cells and pancreatic cancer cells are able to modulate T cell activation.f46d1bb97ccaP01850 - UniProt identifierType your comment heref2af2ab62f2af2ac5dP01848 - UniProt identifierType your comment hereP01137 - UniProt identifierType your comment hereP01137 - UniProt identifierType your comment hereP01137 - UniProt identifierType your comment hered54f2af8bbfce5fbfce5fbfcb97pancreatic cancerDOID:1793Disease30060755PubMedTumor microenvironment participates in metastasis of pancreatic cancer.Mol Cancer2018Ren BCui MYang GWang HFeng MYou LZhao Y35433470PubMedRole of CD155/TIGIT in Digestive Cancers: Promising Cancer Target for Immunotherapy.Front Oncol2022Wang DGu YYan XHuo CWang GZhao YTeng MLi Y36056093PubMedICOS is upregulated on T cells following radiation and agonism combined with radiation results in enhanced tumor control.Sci Rep2022Blair TBaird JBambina SKramer GGostissa MHarvey CJGough MJCrittenden MRpancreatic stellate cellCL:0002410Cell Type29254283PubMedFunctions of pancreatic stellate cell-derived soluble factors in the microenvironment of pancreatic ductal carcinoma.Oncotarget2017Wu QTian YZhang JZhang HGu FLu YZou SChen YSun PXu MSun XXia CChi HYing Zhu ATang DWang D35046623PubMedT cells in pancreatic cancer stroma.World J Gastroenterol2021Goulart MRStasinos KFincham READelvecchio FRKocher HM31831007PubMedThe reciprocal regulation between host tissue and immune cells in pancreatic ductal adenocarcinoma: new insights and therapeutic implications.Mol Cancer2019Liu XXu JZhang BLiu JLiang CMeng QHua JYu XShi S33395072PubMedArginine metabolism: a potential target in pancreatic cancer therapy.Chin Med J (Engl)2020Yang JSWang CCQiu JDRen BYou Lprofessional antigen presenting cellCL:0000145Cell Typemalignant cellCL:0001064Cell Type33237432PubMedPrognostic significance and therapeutic potential of the immune checkpoint VISTA in pancreatic cancer.J Cancer Res Clin Oncol2021Hou ZPan YFei QLin YZhou YLiu YGuan HYu XLin XLu FHuang H32823814PubMedMechanisms of T-Cell Exhaustion in Pancreatic Cancer.Cancers (Basel)2020Saka DGökalp MPiyade BCevik NCArik Sever EUnutmaz DCeyhan GODemir IEAsimgil H28734735PubMedMetabolic Interactions in the Tumor Microenvironment.Trends Cell Biol2017Lyssiotis CAKimmelman ACmyeloid suppressor cellCL:0000889Cell Type24315741PubMedRole of the immune system in pancreatic cancer progression and immune modulating treatment strategies.Cancer Treat Rev2013Sideras KBraat HKwekkeboom Jvan Eijck CHPeppelenbosch MPSleijfer SBruno Mimmune response pathwayPW:0000023Pathway Ontologypancreatic cancer pathwayPW:0000626Pathway OntologyT cellCL:0000084Cell TypeCD8-positive, alpha-beta T cellCL:0000625Cell Typedisease pathwayPW:0000013Pathway Ontology