Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms (WP4534)

Homo sapiens

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Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms. This pathway was created based on figure 2 from Dobrokhotov et al. Phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org.

Authors

Friederike Ehrhart and Kristina Hanspers

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

Hippo signaling pathway mechanotransduction pathway

Disease Ontology

cancer

Participants
Query Drugst.One

Label Type Compact URI Comment
ACTA1 GeneProduct ncbigene:58 Actin
ACTA2 GeneProduct ncbigene:59 Actin
MAPK10 GeneProduct ncbigene:5602 JNK
STK3 GeneProduct ncbigene:6788 MST1/2
PAK1 GeneProduct ncbigene:5058 PAK
PAK2 GeneProduct ncbigene:5062 PAK
PAK3 GeneProduct ncbigene:5063 PAK
PAK4 GeneProduct ncbigene:10298 PAK
PAK5 GeneProduct ncbigene:57144 PAK
PAK6 GeneProduct ncbigene:56924 PAK
SAV1 GeneProduct ncbigene:60485 SAV1
TEAD2 GeneProduct ncbigene:8463 TEAD1-4
TEAD3 GeneProduct ncbigene:7005 TEAD1-4
TEAD4 GeneProduct ncbigene:7004 TEAD1-4
WWTR1 GeneProduct ncbigene:25937 YAP/TAZ
ITGB5 GeneProduct ensembl:ENSG00000082781
YWHAQ GeneProduct ncbigene:10971 14-3-3
MAPK8 GeneProduct ncbigene:5599 JNK
ACTC1 GeneProduct ncbigene:70 Actin
MAP4K2 GeneProduct ensembl:ENSG00000168067
SRC GeneProduct ncbigene:6714 Src
ACTB GeneProduct ncbigene:60 Actin
ITGB7 GeneProduct ensembl:ENSG00000139626
YAP1 GeneProduct ncbigene:10413 YAP/TAZ
ACTG2 GeneProduct ncbigene:72 Actin
ITGB8 GeneProduct ensembl:ENSG00000105855
ITGB6 GeneProduct ensembl:ENSG00000115221
CDH1 GeneProduct ncbigene:999 E-cadherin
MAP4K5 GeneProduct ensembl:ENSG00000012983
SGMS1 GeneProduct ncbigene:259230 MOB
ITGB4 GeneProduct ensembl:ENSG00000132470
MAP4K3 GeneProduct ensembl:ENSG00000011566
TEAD1 GeneProduct ncbigene:7003 TEAD1-4
ITGB3 GeneProduct ensembl:ENSG00000259207
ITGB2 GeneProduct ensembl:ENSG00000160255
ACTG1 GeneProduct ncbigene:71 Actin
LATS1 GeneProduct ncbigene:9113 LATS1/2MAP4Ks
ITGB1 GeneProduct ensembl:ENSG00000150093
LIMD1 GeneProduct ncbigene:8994 LIMD1
NF2 GeneProduct ncbigene:4771 Merlin
MAP4K4 GeneProduct ensembl:ENSG00000071054
STK4 GeneProduct ncbigene:4485 MST1/2
MAP4K1 GeneProduct ensembl:ENSG00000104814
MAPK9 GeneProduct ncbigene:5601 JNK
CTNNB1 GeneProduct ensembl:ENSG00000168036
CDH1 GeneProduct ncbigene:999 E-cadherin
NF2 GeneProduct ncbigene:4771 Merlin
CTNNA1 GeneProduct ensembl:ENSG00000044115
CDH1 GeneProduct ncbigene:999 E-cadherin
CTNNB1 GeneProduct ensembl:ENSG00000168036
CDH1 GeneProduct ncbigene:999 E-cadherin
CTNNA1 GeneProduct ensembl:ENSG00000044115

References

  1. PhosphoSitePlus, 2014: mutations, PTMs and recalibrations. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E. Nucleic Acids Res. 2015 Jan;43(Database issue):D512-20. PubMed Europe PMC Scholia
  2. Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms. Dobrokhotov O, Samsonov M, Sokabe M, Hirata H. Clin Transl Med. 2018 Aug 13;7(1):23. PubMed Europe PMC Scholia