Complement and coagulation cascades (WP1056)

Bos taurus

Blood coagulation is a series of coordinated and calcium-dependent proenzyme-to-serine protease conversions likely to be localized on the surfaces of activated cells in vivo. It culminates in the formation of thrombin, the enzyme responsible for the conversion of soluble fibrinogen to the insoluble fibrin clot. The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). Kinin peptides are implicated in many physiological and pathological processes including the regulation of blood pressure and sodium homeostasis, inflammatory processes, and the cardioprotective effects of preconditioning. Complement is a system of plasma proteins that is activated by the presence of pathogens. There are three pathways of complement activation: the classical pathway, the lectin pathway, and the alternative pathway. All of these pathways generate a crucial enzymatic activity that, intern, generates the effector molecules of complement. The three main consequences of complement activation are the opsonization of pathogens, the recruitment of inflammatory and immunocompetent cells, and the direct killing of pathogens. Source: KEGG (http://www.genome.jp/dbget-bin/www_bget?pathway:map04610)

Authors

Alex Pico , Kristina Hanspers , Egon Willighagen , Martina Summer-Kutmon , and Eric Weitz

Activity

last edited

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

complement system pathway

Participants

Label Type Compact URI Comment
Fibrin monomer Metabolite cas:9001-31-4
Bradykinin Metabolite cas:58-82-2
C2 GeneProduct ensembl:ENSBTAG00000007450 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:717
PLAT GeneProduct ensembl:ENSBTAG00000001244 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5327
CFD GeneProduct ensembl:ENSBTAG00000048122 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1675
F8 GeneProduct ensembl:ENSBTAG00000010726 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2157
SERPINA5 GeneProduct ensembl:ENSBTAG00000004063 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5104
F9 GeneProduct ensembl:ENSBTAG00000004003 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2158
F2R GeneProduct ensembl:ENSBTAG00000020199 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2149
CLU GeneProduct ensembl:ENSBTAG00000015027 CLU
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1191
SERPINA1 GeneProduct ensembl:ENSBTAG00000018843 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5265
CFH GeneProduct ensembl:ENSBTAG00000023177 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3075
FGB GeneProduct ensembl:ENSBTAG00000022120 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2244
KLKB1 GeneProduct ensembl:ENSBTAG00000009501 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3818
MASP2 GeneProduct ensembl:ENSBTAG00000012808 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10747
C5AR1 GeneProduct ensembl:ENSBTAG00000020872 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:728
MCP GeneProduct ensembl:ENSBTAG00000030910 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4179
F13B GeneProduct ensembl:ENSBTAG00000000070 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2165
F10 GeneProduct ensembl:ENSBTAG00000016385 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2159
F7 GeneProduct ensembl:ENSBTAG00000007411 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2155
CR2 GeneProduct ensembl:ENSBTAG00000038496 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1380
F3 GeneProduct ensembl:ENSBTAG00000007101 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2152
SERPING1 GeneProduct ensembl:ENSBTAG00000016267 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:710
C1S GeneProduct ensembl:ENSBTAG00000004840 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:716
C1QC GeneProduct ensembl:ENSBTAG00000011193 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:714
BDKRB1 GeneProduct ensembl:ENSBTAG00000007052 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:623
C7 GeneProduct ensembl:ENSBTAG00000011766 MGI:88235 LL:109828
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:730
F5 GeneProduct ensembl:ENSBTAG00000017722 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2153
VWF GeneProduct ensembl:ENSBTAG00000012265 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7450
PLAU GeneProduct ensembl:ENSBTAG00000005947 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5328
SERPINF2 GeneProduct ensembl:ENSBTAG00000020859 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5345
C3AR1 GeneProduct ensembl:ENSBTAG00000019741 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:719
THBD GeneProduct ensembl:ENSBTAG00000002758 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7056
CLTC GeneProduct ensembl:ENSBTAG00000016708 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1213
CFI GeneProduct ensembl:ENSBTAG00000034501 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3426
F2 GeneProduct ensembl:ENSBTAG00000007148 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2147
C1R GeneProduct ensembl:ENSBTAG00000037743 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:715
PROC GeneProduct ensembl:ENSBTAG00000003950 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5624
CD55 GeneProduct ensembl:ENSBTAG00000006984 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1604
PROS1 GeneProduct ensembl:ENSBTAG00000023652 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5627
PLAUR GeneProduct ensembl:ENSBTAG00000013125 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5329
C1QB GeneProduct ensembl:ENSBTAG00000011196 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:713
SERPINE1 GeneProduct ensembl:ENSBTAG00000014465 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5054
C6 GeneProduct ensembl:ENSBTAG00000014177 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:729
C1QA GeneProduct ensembl:ENSBTAG00000007153 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:712
C8G GeneProduct ensembl:ENSBTAG00000010520 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:733
F12 GeneProduct ensembl:ENSBTAG00000018872 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2161
LMAN1 GeneProduct ensembl:ENSBTAG00000006833 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3998
C9 GeneProduct ensembl:ENSBTAG00000016149 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:735
SERPINC1 GeneProduct ensembl:ENSBTAG00000004362 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:462
PLG GeneProduct ensembl:ENSBTAG00000001271 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5340
SERPIND1 GeneProduct ensembl:ENSBTAG00000013973 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3053
C3 GeneProduct ensembl:ENSBTAG00000017280 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:718
CFB GeneProduct ensembl:ENSBTAG00000046158 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:629
MASP1 GeneProduct ensembl:ENSBTAG00000012467 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5648
CPB2 GeneProduct ensembl:ENSBTAG00000007073 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1361
C4 GeneProduct ensembl:ENSBTAG00000037533 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:721
KNG1 GeneProduct ensembl:ENSBTAG00000005122 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3827

References