Overview of proinflammatory and profibrotic mediators (WP5095)

Homo sapiens

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Inflammatory cytokines leading to cytokine storm after NF-kappa-B and prostaglandin activation. KEGG pathway 05171 and a paper by Robb et al. was referenced for the pathway development.

Authors

Stefan Raats , Aria Jadhav , Marvin Martens , Duygu Dede Sener , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

pro-inflammatory cytokine mediated pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
ROS Metabolite chebi:26523
Prostaglandin E2 Metabolite chebi:15551
Prostaglandin I2 Metabolite cas:35121-78-9
IL4 GeneProduct ensembl:ENSG00000113520
IFNG GeneProduct ensembl:ENSG00000111537
IFNB1 GeneProduct ensembl:ENSG00000171855
SPP1 GeneProduct ensembl:ENSG00000118785
IL23A GeneProduct ensembl:ENSG00000110944
IFNA16 GeneProduct ensembl:ENSG00000147885
IL24 GeneProduct ensembl:ENSG00000162892
IFNA17 GeneProduct ensembl:ENSG00000234829
IFNK GeneProduct ensembl:ENSG00000147896
IFNL2 GeneProduct ensembl:ENSG00000183709
IL12B GeneProduct ensembl:ENSG00000113302
IFNA8 GeneProduct ensembl:ENSG00000120242
CCL1 GeneProduct ensembl:ENSG00000108702
IL13 GeneProduct ensembl:ENSG00000169194
IFNA13 GeneProduct ensembl:ENSG00000233816
IL36A GeneProduct ensembl:ENSG00000136694
IFNL3 GeneProduct ensembl:ENSG00000197110
CXCL1 GeneProduct ensembl:ENSG00000163739
IL21 GeneProduct ensembl:ENSG00000138684
IL12B GeneProduct ensembl:ENSG00000113302
IL15 GeneProduct ensembl:ENSG00000164136
IFNA2 GeneProduct ensembl:ENSG00000188379
IL2 GeneProduct ensembl:ENSG00000109471
IL24 GeneProduct ensembl:ENSG00000162892
TSLP GeneProduct ensembl:ENSG00000145777
IL1F10 GeneProduct ensembl:ENSG00000136697
IL19 GeneProduct ensembl:ENSG00000142224
IL36RN GeneProduct ensembl:ENSG00000136695
OSM GeneProduct ensembl:ENSG00000099985
TNF GeneProduct ensembl:ENSG00000232810
IL9 GeneProduct ensembl:ENSG00000145839
IL26 GeneProduct ensembl:ENSG00000111536
IFNL2 GeneProduct ensembl:ENSG00000183709
IL10 GeneProduct ensembl:ENSG00000136634
IL6 GeneProduct ensembl:ENSG00000136244
IL25 GeneProduct ensembl:ENSG00000166090
IFNA14 GeneProduct ensembl:ENSG00000228083
IL7 GeneProduct ensembl:ENSG00000104432
CSF1 GeneProduct ensembl:ENSG00000184371
IL1A GeneProduct ensembl:ENSG00000115008
IFNL1 GeneProduct ensembl:ENSG00000182393
IFNA7 GeneProduct ensembl:ENSG00000214042
IL20 GeneProduct ensembl:ENSG00000162891
EPO GeneProduct ensembl:ENSG00000130427
CCL28 GeneProduct ensembl:ENSG00000151882
IFNW1 GeneProduct ensembl:ENSG00000177047
LIF GeneProduct ensembl:ENSG00000128342
CSF2 GeneProduct ensembl:ENSG00000164400
IL3 GeneProduct ensembl:ENSG00000164399
IL12A GeneProduct ensembl:ENSG00000168811
IL27 GeneProduct ensembl:ENSG00000197272
IL1RN GeneProduct ensembl:ENSG00000136689
IFNA1 GeneProduct ensembl:ENSG00000197919
IL11 GeneProduct ensembl:ENSG00000095752
IL22 GeneProduct ensembl:ENSG00000127318
IFNA5 GeneProduct ensembl:ENSG00000147873
IL31 GeneProduct ensembl:ENSG00000204671
IL5 GeneProduct ensembl:ENSG00000113525
CTF1 GeneProduct ensembl:ENSG00000150281
IL1B GeneProduct ensembl:ENSG00000125538
EBI3 GeneProduct ensembl:ENSG00000105246
IL37 GeneProduct ensembl:ENSG00000125571
IFNA4 GeneProduct ensembl:ENSG00000236637
IFNA6 GeneProduct ensembl:ENSG00000120235
IL18 GeneProduct ensembl:ENSG00000150782
IL33 GeneProduct ensembl:ENSG00000137033
CNTF GeneProduct ensembl:ENSG00000242689
IL2 GeneProduct ensembl:ENSG00000109471
IL-8 GeneProduct ensembl:ENSG00000169429
MMP3 GeneProduct ensembl:ENSG00000149968
CSF3 GeneProduct ensembl:ENSG00000108342
CCL2 GeneProduct ncbigene:6347
CSF2 GeneProduct ensembl:ENSG00000164400
CXCL10 GeneProduct ensembl:ENSG00000169245
TNF alpha GeneProduct ensembl:ENSG00000232810
IL-12 GeneProduct hgnc.symbol:IL12A
IL-1 Beta GeneProduct ensembl:ENSG00000125538
MMP1 GeneProduct ensembl:ENSG00000196611
IL-6 GeneProduct ensembl:ENSG00000136244
IL-6 GeneProduct ensembl:ENSG00000136244
IL-1 Beta GeneProduct ensembl:ENSG00000125538
IL-8 GeneProduct ensembl:ENSG00000169429
CCL2 GeneProduct ncbigene:6347
TNF alpha GeneProduct ensembl:ENSG00000232810
IL-12 GeneProduct hgnc.symbol:IL12A
VEGFA GeneProduct ensembl:ENSG00000112715
MMP9 GeneProduct ensembl:ENSG00000100985
TGFB1 GeneProduct ensembl:ENSG00000105329
CXCL1 GeneProduct ensembl:ENSG00000163739
CSF1 GeneProduct ensembl:ENSG00000184371
AREG GeneProduct ensembl:ENSG00000109321
IL17F GeneProduct ensembl:ENSG00000112116
IL17A GeneProduct ensembl:ENSG00000112115
IL22 GeneProduct hgnc.symbol:IL22
CXCL9 GeneProduct ensembl:ENSG00000138755
IFNG GeneProduct ensembl:ENSG00000111537
IFNA1 GeneProduct ensembl:ENSG00000197919
IL15 GeneProduct ensembl:ENSG00000164136
IL2 GeneProduct ensembl:ENSG00000109471
IL36B GeneProduct ensembl:ENSG00000136696
IL36G GeneProduct ensembl:ENSG00000136688
TNFSF13B GeneProduct ensembl:ENSG00000102524
TNFSF13 GeneProduct ensembl:ENSG00000161955
IL17A GeneProduct ensembl:ENSG00000112115
IL17B GeneProduct ensembl:ENSG00000127743
IL17D GeneProduct ensembl:ENSG00000172458
IL17F GeneProduct ensembl:ENSG00000112116
IL17C GeneProduct ensembl:ENSG00000124391
IFNA10 GeneProduct ensembl:ENSG00000186803
IFNA21 GeneProduct ensembl:ENSG00000137080
IL12A GeneProduct ensembl:ENSG00000168811
IFNL3 GeneProduct ensembl:ENSG00000197110
IFNL1 GeneProduct ensembl:ENSG00000182393
CSF3 GeneProduct ensembl:ENSG00000108342
CSF2 GeneProduct ensembl:ENSG00000164400
CCL2 GeneProduct ensembl:ENSG00000108691
CCL3 GeneProduct ensembl:ENSG00000277632
CCL3L3 GeneProduct ensembl:ENSG00000276085
CCL4 GeneProduct ensembl:ENSG00000275302
CCL4L2 GeneProduct ensembl:ENSG00000276070
CCL5 GeneProduct ensembl:ENSG00000271503
CCL13 GeneProduct ensembl:ENSG00000181374
CCL7 GeneProduct ensembl:ENSG00000108688
CCL8 GeneProduct ensembl:ENSG00000108700
CCL11 GeneProduct ensembl:ENSG00000172156
CCL14 GeneProduct ensembl:ENSG00000276409
CCL15 GeneProduct ensembl:ENSG00000275718
CCL16 GeneProduct ensembl:ENSG00000275152
CCL17 GeneProduct ensembl:ENSG00000102970
CCL18 GeneProduct ensembl:ENSG00000275385
CCL19 GeneProduct ensembl:ENSG00000172724
CCL20 GeneProduct ensembl:ENSG00000115009
CCL21 GeneProduct ensembl:ENSG00000137077
CCL22 GeneProduct ensembl:ENSG00000102962
CCL23 GeneProduct ensembl:ENSG00000274736
CCL24 GeneProduct ensembl:ENSG00000106178
CCL25 GeneProduct ensembl:ENSG00000131142
CCL27 GeneProduct ensembl:ENSG00000213927
CCL26 GeneProduct ensembl:ENSG00000006606
XCL1 GeneProduct ensembl:ENSG00000143184
XCL2 GeneProduct ensembl:ENSG00000143185
CXCL2 GeneProduct ensembl:ENSG00000081041
CXCL3 GeneProduct ensembl:ENSG00000163734
CXCL5 GeneProduct ensembl:ENSG00000163735
CXCL6 GeneProduct ensembl:ENSG00000124875
PPBP GeneProduct ensembl:ENSG00000163736
CXCL10 GeneProduct ensembl:ENSG00000169245
CXCL11 GeneProduct ensembl:ENSG00000169248
CXCL12 GeneProduct ensembl:ENSG00000107562
CXCL16 GeneProduct ensembl:ENSG00000161921
CXCL17 GeneProduct ensembl:ENSG00000189377
CX3CL1 GeneProduct ensembl:ENSG00000006210
PF4 GeneProduct ensembl:ENSG00000163737
PF4V1 GeneProduct ensembl:ENSG00000109272
CXCL8 GeneProduct ensembl:ENSG00000169429
CXCL9 GeneProduct ensembl:ENSG00000138755
CXCL13 GeneProduct ensembl:ENSG00000156234
CXCL14 GeneProduct ensembl:ENSG00000145824
NF-kappa-B Protein uniprot:D6RC45
Lymphotoxin-alpha Protein uniprot:P01374

References

  1. Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease. Turner MD, Nedjai B, Hurst T, Pennington DJ. Biochim Biophys Acta. 2014 Nov;1843(11):2563–82. PubMed Europe PMC Scholia
  2. Non-steroidal anti-inflammatory drugs, prostaglandins, and COVID-19. Robb CT, Goepp M, Rossi AG, Yao C. Br J Pharmacol. 2020 Nov;177(21):4899–920. PubMed Europe PMC Scholia