Glycerolipids and glycerophospholipids (WP4722)
Homo sapiens
This pathway is inspired by the Lipidmaps>Glycerolipids and Glycerophospholipids Pathways expended pathway display [1]. Glycerolipids are composed of mono-, di-, and tri-substituted glycerols, which all function as energy storage. Glycerophospholipids are also based on glycerol phospholipids, and serve as the main component of biological membranes.
For a description of pathway objects, see the WikiPathways Legend.
Authors
Denise Slenter , Eric Weitz , Egon Willighagen , and Daniela DiglesActivity
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Cited In
- Exome-wide association analysis identifies novel risk loci for alcohol-associated hepatitis (2024).
- Extending inherited metabolic disorder diagnostics with biomarker interaction visualizations (2023).
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Organisms
Homo sapiensCommunities
Lipids and LIPID MAPSAnnotations
Pathway Ontology
glycerolipid metabolic pathway glycerophospholipid metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| CoA(16:0) | Metabolite | cas:1763-10-6 | AKA 'Coenzyme A, S-hexadecanoate' |
| CoA | Metabolite | chebi:15346 | |
| PA | Metabolite | lipidmaps:LMGP10010000 | aka phosphatidic acid |
| Glycerol-3-P | Metabolite | pubchem.compound:439162 | |
| 1-acyl-LPA | Metabolite | lipidmaps:LMGP10050000 | aka 1-acyl-sn-glycero-3-phosphate , 1-acylglycerophosphate, lysophosphatic acid |
| Choline | Metabolite | pubchem.compound:305 | |
| CDP-Etn | Metabolite | pubchem.compound:123727 | |
| PE | Metabolite | lipidmaps:LMGP02010000 | |
| Acyl-CoA | Metabolite | lipidmaps:LMFA07050000 | |
| DAG | Metabolite | lipidmaps:LMGL02010000 | |
| CDP-DAG | Metabolite | lipidmaps:LMGP13010000 | |
| PGP | Metabolite | lipidmaps:LMGP05010000 | |
| PG | Metabolite | lipidmaps:LMGP04010000 | |
| CL | Metabolite | lipidmaps:LMGP12010000 | |
| PI | Metabolite | lipidmaps:LMGP06010000 | |
| PC | Metabolite | lipidmaps:LMGP01010000 | |
| Choline-P | Metabolite | pubchem.compound:135437 | |
| CDP-Choline | Metabolite | pubchem.compound:13804 | |
| PS | Metabolite | lipidmaps:LMGP03010000 | |
| 1-acyl-LPC | Metabolite | lipidmaps:LMGP01050000 | |
| PE-Me | Metabolite | lipidmaps:LMGP0201AA00 | |
| PE-Me2 | Metabolite | lipidmaps:LMGP0201AB00 | |
| Etn-P | Metabolite | pubchem.compound:1015 | |
| Etn | Metabolite | pubchem.compound:700 | |
| TAG | Metabolite | lipidmaps:LMGL03010000 | |
| 2-acyl-PA | Metabolite | lipidmaps:LMGP1005AA00 | |
| 1-acyl-PE | Metabolite | lipidmaps:LMGP02050000 | |
| CoA(18:0) | Metabolite | cas:362-66-3 | AKA 'Coenzyme A, S-octadecanoate' |
| CoA(20:0) | Metabolite | cas:15895-27-9 | AKA 'Coenzyme A, S-eicosanoate' |
| LPC | Metabolite | lipidmaps:LMGP01050000 | AKA '1-acyl-sn-glycero-3-phosphocholine' |
| LPE | Metabolite | lipidmaps:LMGP02050000 | AKA '1-acyl-sn-glycero-3-phosphoethanolamine' |
| GPAM | GeneProduct | ensembl:ENSG00000119927 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14732 |
| CRLS1 | GeneProduct | ensembl:ENSG00000088766 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66586 |
| CHPT1 | GeneProduct | ensembl:ENSG00000111666 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:212862 |
| PCYT2 | GeneProduct | ensembl:ENSG00000185813 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:68671 |
| CDS1 | GeneProduct | ensembl:ENSG00000163624 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74596 |
| PISD | GeneProduct | ensembl:ENSG00000241878 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:320951 |
| DGAT1 | GeneProduct | ensembl:ENSG00000185000 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13350 |
| PTDSS2 | GeneProduct | ensembl:ENSG00000174915 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:27388 |
| PNPLA2 | GeneProduct | ensembl:ENSG00000177666 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66853 |
| PLD1 | GeneProduct | ensembl:ENSG00000075651 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18805 |
| DGKZ | GeneProduct | ensembl:ENSG00000149091 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:104418 |
| PTDSS1 | GeneProduct | ensembl:ENSG00000156471 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19210 |
| PEMT | GeneProduct | ensembl:ENSG00000133027 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18618 |
| AGPAT4 | GeneProduct | ensembl:ENSG00000026652 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:68262 |
| CDIPT | GeneProduct | ensembl:ENSG00000103502 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:52858 |
| CHKB | GeneProduct | ensembl:ENSG00000100288 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12651 |
| PCYT1A | GeneProduct | ensembl:ENSG00000161217 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13026 |
| ETNK1 | GeneProduct | ensembl:ENSG00000139163 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75320 |
| GPAT4 | GeneProduct | ensembl:ENSG00000158669 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:102247 |
| DGAT2 | GeneProduct | ensembl:ENSG00000062282 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67800 |
| PLA2G1B | GeneProduct | ensembl:ENSG00000170890 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18778 |
| PNPLA3 | Protein | ensembl:ENSG00000100344 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:116939 |
References
- A mouse macrophage lipidome. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia
- Glycerophosphate/Acylglycerophosphate acyltransferases. Yamashita A, Hayashi Y, Matsumoto N, Nemoto-Sasaki Y, Oka S, Tanikawa T, et al. Biology (Basel). 2014 Nov 19;3(4):801–30. PubMed Europe PMC Scholia