Nuclear receptors (WP1068)

Bos taurus

Nuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, these receptors work in concert with other proteins to regulate the expression of specific genes thereby controlling the development, homeostasis, and metabolism of the organism. Nuclear receptors have the ability to directly bind to DNA and regulate the expression of adjacent genes, hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors only happens when a liganda molecule which affects the receptor's behavioris present. More specifically, ligand binding to a nuclear receptor results in a conformational change in the receptor which in turn activates the receptor resulting in up-regulation of gene expression. A unique property of nuclear receptors which differentiate them from other classes of receptors is their ability to directly interact with and control the expression of genomic DNA. Consequently nuclear receptors play key roles in both embryonic development and adult homeostasis. Source: Wikipedia ([[wikipedia:Nuclear_receptor]])

Authors

Alex Pico , Daniela Digles , Martina Summer-Kutmon , and Eric Weitz

Activity

last edited

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

transcription factor mediated signaling pathway

Participants

Label Type Compact URI Comment
retinoicacid Metabolite chebi:26536
Oxysterols Metabolite chebi:53030
d3 vitamins Metabolite chebi:73558
estrogen Metabolite chebi:50114
progesterone Metabolite chebi:17026
THRA GeneProduct ensembl:ENSBTAG00000010745 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7067
THRB GeneProduct ensembl:ENSBTAG00000017802 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7068
RARA GeneProduct ensembl:ENSBTAG00000012500 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5914
RARB GeneProduct ensembl:ENSBTAG00000011518 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5915
RARG GeneProduct ensembl:ENSBTAG00000007592 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5916
PPARA GeneProduct ensembl:ENSBTAG00000008063 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5465
PPARD GeneProduct ensembl:ENSBTAG00000017542 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5467
PPARG GeneProduct ensembl:ENSBTAG00000001333 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5468
NR1D2 GeneProduct ensembl:ENSBTAG00000018024 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9975
NR0B1 GeneProduct ensembl:ENSBTAG00000015532 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:190
ROR1 GeneProduct ensembl:ENSBTAG00000012312 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4919
RORA GeneProduct ensembl:ENSBTAG00000015904 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6095
RORC GeneProduct ensembl:ENSBTAG00000017405 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6097
NR1H2 GeneProduct ensembl:ENSBTAG00000003264 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7376
NR1H3 GeneProduct ensembl:ENSBTAG00000010681 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10062
VDR GeneProduct ensembl:ENSBTAG00000016414 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7421
HNF4A GeneProduct ensembl:ENSBTAG00000012116 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3172
RXRA GeneProduct ensembl:ENSBTAG00000017851 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6256
RXRB GeneProduct ensembl:ENSBTAG00000000602 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6257
RXRG GeneProduct ensembl:ENSBTAG00000016801 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6258
NR2C2 GeneProduct ensembl:ENSBTAG00000013716 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7182
NR2F1 GeneProduct ensembl:ENSBTAG00000017599 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7025
NR2F2 GeneProduct ensembl:ENSBTAG00000018007 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7026
NR2F6 GeneProduct ensembl:ENSBTAG00000011136 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2063
NR2E1 GeneProduct ensembl:ENSBTAG00000013991 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7101
ESR1 GeneProduct ensembl:ENSBTAG00000007159 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2099
ESR2 GeneProduct ensembl:ENSBTAG00000004498 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2100
ESRRA GeneProduct ensembl:ENSBTAG00000008645 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2101
ESRRB GeneProduct ensembl:ENSBTAG00000012285 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2103
GR-A GeneProduct ensembl:ENSBTAG00000019472 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2908
PGR GeneProduct ensembl:ENSBTAG00000024648 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5241
AR GeneProduct ensembl:ENSBTAG00000022255 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:367
NR4A1 GeneProduct ensembl:ENSBTAG00000000507 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3164
NR4A2 GeneProduct ensembl:ENSBTAG00000003650 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4929
NR5A1 GeneProduct ensembl:ENSBTAG00000009017 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2516
NR5A2 GeneProduct ensembl:ENSBTAG00000009265 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2494
NR1I2 GeneProduct ensembl:ENSBTAG00000019557 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8856
NR1I3 GeneProduct ensembl:ENSBTAG00000009215 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9970

References

  1. Twenty years of nuclear receptors: Conference on Nuclear Receptors: from Chromatin to Disease. Nagy L, Schüle R, Gronemeyer H. EMBO Rep. 2006 Jun;7(6):579–84. PubMed Europe PMC Scholia