Calcium mediated T-cell apoptosis involved in inclusion body myositis (WP5142)
Homo sapiens
Inclusion body myositis is a late onset disease of the muscles. It shares both degenerative and autoimmune features, as well as genetic factors, and also is resistant to classical treatments of immunosuppressive drugs. This pathway is based on Figure 3 of Johari M. et al. 2021.
Authors
TheodorosZarotiadis , Eric Weitz , and Friederike EhrhartActivity
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Organisms
Homo sapiensCommunities
Rare DiseasesAnnotations
Pathway Ontology
apoptotic cell death pathway disease pathwayDisease Ontology
inclusion body myositis| Label | Type | Compact URI | Comment |
|---|---|---|---|
| IP3 | Metabolite | pubchem.compound:55310 | |
| Ca2+ | Metabolite | chebi:29108 | |
| Ca2+ | Metabolite | chebi:29108 | |
| Ca2+ | Metabolite | chebi:29108 | |
| Ca2+ | Metabolite | chebi:29108 | |
| PIP2 | Metabolite | wikidata:Q3083814 | |
| DAG | Metabolite | pubchem.compound:6026790 | |
| CALM1 | GeneProduct | ensembl:ENSG00000198668 | Refers to the calmodulin family of genes |
| CRAC | GeneProduct | pfam:PF07856 | |
| NR4A1 | GeneProduct | ensembl:ENSG00000123358 | NUR77 |
| ATP2A1 | GeneProduct | ensembl:ENSG00000196296 | SERCACalcium channel - Supervises intracellular Ca levels |
| EP300 | GeneProduct | ensembl:ENSG00000100393 | |
| LCK | GeneProduct | ensembl:ENSG00000182866 | |
| PPP3CB | GeneProduct | ensembl:ENSG00000107758 | |
| CABIN1 | GeneProduct | ensembl:ENSG00000099991 | |
| MEF2D | GeneProduct | ensembl:ENSG00000116604 | |
| PLCG1 | GeneProduct | ensembl:ENSG00000124181 | |
| MHC class I / CD8B | GeneProduct | ensembl:ENSG00000172116 | CD8 glycoprotein co-receptor for the T cell receptor (TCR). This is the beta isoform of the protein. |
| MHC class I / CD8A | GeneProduct | ensembl:ENSG00000153563 | CD8 glycoprotein co-receptor for the T cell receptor (TCR). This is the alpha isoform of the protein. |
| MHC class II / CD4 | GeneProduct | ensembl:ENSG00000010610 | CD4 glycoprotein co-receptor for the T cell receptor (TCR). |
| ITPRIP | GeneProduct | ensembl:ENSG00000148841 | IP3 receptor for the calcium channel |
| ZAP70 | GeneProduct | ensembl:ENSG00000115085 | |
| PPP3CA | GeneProduct | ensembl:ENSG00000138814 | calcineurin |
| NFATC2 | GeneProduct | ensembl:ENSG00000101096 | |
| CAPN2 | GeneProduct | ensembl:ENSG00000162909 | |
| PPP3CC | GeneProduct | ensembl:ENSG00000120910 | |
| NFATC2 | GeneProduct | ensembl:ENSG00000101096 | |
| NFATC2 | GeneProduct | ensembl:ENSG00000101096 | |
| CABIN1 | GeneProduct | ensembl:ENSG00000099991 | |
| HDAC1 | Protein | uniprot:Q13547 | |
| TCR | Protein | pfam:PF11628 | T cell receptor (TCR) complex |
| HDAC2 | Protein | uniprot:Q92769 | |
| PKC | Protein | pfam:PF00433 |