Calcium mediated T-cell apoptosis involved in inclusion body myositis (WP5142)

Homo sapiens

Inclusion body myositis is a late onset disease of the muscles. It shares both degenerative and autoimmune features, as well as genetic factors, and also is resistant to classical treatments of immunosuppressive drugs. This pathway is based on Figure 3 of Johari M. et al. 2021.


TheodorosZarotiadis , Eric Weitz , and Friederike Ehrhart


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Homo sapiens


Rare Diseases


Pathway Ontology

apoptotic cell death pathway disease pathway

Disease Ontology

inclusion body myositis


Label Type Compact URI Comment
IP3 Metabolite pubchem.compound:55310
Ca2+ Metabolite chebi:29108
Ca2+ Metabolite chebi:29108
Ca2+ Metabolite chebi:29108
Ca2+ Metabolite chebi:29108
PIP2 Metabolite wikidata:Q3083814
DAG Metabolite pubchem.compound:6026790
CALM1 GeneProduct ensembl:ENSG00000198668 Refers to the calmodulin family of genes
CRAC GeneProduct pfam:PF07856
NR4A1 GeneProduct ensembl:ENSG00000123358 NUR77
ATP2A1 GeneProduct ensembl:ENSG00000196296 SERCA
Calcium channel - Supervises intracellular Ca levels
EP300 GeneProduct ensembl:ENSG00000100393
LCK GeneProduct ensembl:ENSG00000182866
PPP3CB GeneProduct ensembl:ENSG00000107758
CABIN1 GeneProduct ensembl:ENSG00000099991
MEF2D GeneProduct ensembl:ENSG00000116604
PLCG1 GeneProduct ensembl:ENSG00000124181
MHC class I / CD8B GeneProduct ensembl:ENSG00000172116 CD8 glycoprotein co-receptor for the T cell receptor (TCR). This is the beta isoform of the protein.
MHC class I / CD8A GeneProduct ensembl:ENSG00000153563 CD8 glycoprotein co-receptor for the T cell receptor (TCR). This is the alpha isoform of the protein.
MHC class II / CD4 GeneProduct ensembl:ENSG00000010610 CD4 glycoprotein co-receptor for the T cell receptor (TCR).
ITPRIP GeneProduct ensembl:ENSG00000148841 IP3 receptor for the calcium channel
ZAP70 GeneProduct ensembl:ENSG00000115085
PPP3CA GeneProduct ensembl:ENSG00000138814 calcineurin
NFATC2 GeneProduct ensembl:ENSG00000101096
CAPN2 GeneProduct ensembl:ENSG00000162909
PPP3CC GeneProduct ensembl:ENSG00000120910
NFATC2 GeneProduct ensembl:ENSG00000101096
NFATC2 GeneProduct ensembl:ENSG00000101096
CABIN1 GeneProduct ensembl:ENSG00000099991
HDAC1 Protein uniprot:Q13547
TCR Protein pfam:PF11628 T cell receptor (TCR) complex
HDAC2 Protein uniprot:Q92769
PKC Protein pfam:PF00433