Signal transduction of S1P receptor (WP57)

Mus musculus

This is a representation of figure 2 from T. Hla, et al. 2001, Science, 294, pg. 1877. Sphingosine-1-phosphate (S1P) is a signaling sphingolipid, also known as lysosphingolipid. It is also referred to as a bioactive lipid mediator. Sphingolipids at large form a class of lipids characterized by a particular aliphatic aminoalcohol, which is sphingosine.


Scott Doniger , Daniela Digles , Kristina Hanspers , and Eric Weitz


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Mus musculus



Pathway Ontology

sphingosine 1-phosphate signaling pathway


Label Type Compact URI Comment
Mapk3 GeneProduct ncbigene:26417
Pik3c2g GeneProduct ncbigene:18705
Edg3 GeneProduct ncbigene:13610
Mapk1 GeneProduct ncbigene:26413
Racgap1 GeneProduct ncbigene:26934
Edg1 GeneProduct ncbigene:13609
Sphk1 GeneProduct ncbigene:20698
Gnai1 GeneProduct ncbigene:14677
Mapk7 GeneProduct ncbigene:23939
Plcb3 GeneProduct ncbigene:18797
Akt2 GeneProduct ncbigene:11652
Asah2 GeneProduct ncbigene:54447
Smpd2 GeneProduct ncbigene:20598
Gnai2 GeneProduct ncbigene:14678
Edg8 GeneProduct ncbigene:94226
Mapk12 GeneProduct ncbigene:29857
Akt3 GeneProduct ncbigene:23797
Akt1 GeneProduct ncbigene:11651
Mapk6 GeneProduct ncbigene:50772
Sphk2 GeneProduct ncbigene:56632
Gnai3 GeneProduct ncbigene:14679
Edg5 GeneProduct ncbigene:14739