Wnt/beta-catenin signaling pathway in leukemia (WP3658)

Homo sapiens

The Wnt/Beta-catenin pathway mediates the transcription of proteins important for maintenance and growth of hematopoietic stem cells. The inhibition of Wnt leads to protein degradation through Beta-Catenin activation by the Axin/APC/CK1/GSK3B protein complex. This pathway is based on figure 5 from Misaghian et al. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3658 CPTAC Assay Portal]


AAR&Co , Linda Rieswijk , Kristina Hanspers , Mick Eikelhof , Andika Tan , and Eric Weitz


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Homo sapiens


CPTAC Diseases


Disease Ontology


Pathway Ontology

altered Wnt signaling pathway


Label Type Compact URI Comment
Phosphate Metabolite hmdb:HMDB0001429
Phosphate Metabolite hmdb:HMDB0001429
DKK GeneProduct ensembl:ENSG00000107984 DKK Not Specified
c-MYC GeneProduct ensembl:ENSG00000136997
AML1 GeneProduct ensembl:LRG_482
TCF GeneProduct ensembl:ENSG00000071564 TCF Not Specified
LEF GeneProduct ensembl:ENSG00000138795 LEF Not Specified
PPARD GeneProduct ensembl:ENSG00000112033
GSK3B GeneProduct ensembl:ENSG00000082701
WNT GeneProduct ensembl:ENSG00000125084 Wnt Not Specified
RARA GeneProduct ensembl:ENSG00000131759
PLZF GeneProduct ensembl:ENSG00000109906
BCL9 GeneProduct ensembl:ENSG00000116128
RUNX1T1 GeneProduct ensembl:ENSG00000079102
FLT3 GeneProduct ensembl:ENSG00000122025
PML GeneProduct ensembl:ENSG00000140464
AKT GeneProduct ensembl:ENSG00000142208 Akt Not Specified
RARA GeneProduct ensembl:ENSG00000131759
LRP6 GeneProduct ensembl:ENSG00000070018
APC GeneProduct ensembl:ENSG00000134982
CK1 GeneProduct ensembl:ENSG00000113712
LRP5 GeneProduct ensembl:ENSG00000162337
WIF1 GeneProduct ensembl:ENSG00000156076
AXIN GeneProduct ensembl:ENSG00000168646
SALL4 GeneProduct ensembl:ENSG00000101115
PYGO GeneProduct ensembl:ENSG00000171016 PYGO Not Specified
Junction plakoglobin Protein uniprot:P14923
Frizzled Protein uniprot:E5RGK8 Frizzled Not Specified
cyclin-D1 Protein uniprot:P24385
Catenin beta-1 Protein uniprot:B4DGU4
Catenin beta-1 Protein uniprot:B4DGU4


  1. Targeting the leukemic stem cell: the Holy Grail of leukemia therapy. Misaghian N, Ligresti G, Steelman LS, Bertrand FE, Bäsecke J, Libra M, et al. Leukemia. 2009 Jan;23(1):25–42. PubMed Europe PMC Scholia