Serotonin transporter activity (WP1455)

Homo sapiens

Serotonin is a monoamine neurotransmitter. Biochemically derived from tryptophan, serotonin is primarily found in the gastrointestinal tract (GI tract), blood platelets, and the central nervous system (CNS) of animals, including humans. It is popularly thought to be a contributor to feelings of well-being and happiness. This pathway summarizes the role of the antidepressant-sensitive serotonin (5-HT) transporter SERT (encoded by the SLC6A4 gene).


Vand Conte , Kristina Hanspers , Alex Pico , Thomas Kelder , Allan Kuchinsky , Linda Rieswijk , Egon Willighagen , Martina Summer-Kutmon , and Eric Weitz


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Homo sapiens



Pathway Ontology

serotonin signaling pathway

Cell Type Ontology



Label Type Compact URI Comment
Serotonin Metabolite hmdb:HMDB0000259
L-Tryptophan Metabolite hmdb:HMDB0000929
Citalopram Metabolite hmdb:HMDB0005038
SCAMP2 GeneProduct ncbigene:10066
Hic-5 GeneProduct ncbigene:7041
SLC6A4 GeneProduct ncbigene:6532
ITGB3 GeneProduct ncbigene:3690
IL1B GeneProduct ncbigene:3553
PP2A GeneProduct ncbigene:5516
Syntaxin 1A GeneProduct ncbigene:6804
MAOA GeneProduct ncbigene:4128
nNOS GeneProduct ncbigene:4842
TPH2 GeneProduct ncbigene:121278
IL1R1 GeneProduct ncbigene:3554


  1. Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter. Carneiro AMD, Blakely RD. J Biol Chem. 2006 Aug 25;281(34):24769–80. PubMed Europe PMC Scholia
  2. Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity. Chanrion B, Mannoury la Cour C, Bertaso F, Lerner-Natoli M, Freissmuth M, Millan MJ, et al. Proc Natl Acad Sci U S A. 2007 May 8;104(19):8119–24. PubMed Europe PMC Scholia
  3. Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans. Carneiro AMD, Cook EH, Murphy DL, Blakely RD. J Clin Invest. 2008 Apr;118(4):1544–52. PubMed Europe PMC Scholia