Oxidation by cytochrome P450 (WP1077)

Bos taurus

Oxidation of a substrate by Cytochrome P450. Adapted from Niesink et al., Chapter 3, p. 47-48.

Authors

Alex Pico , Egon Willighagen , Kristina Hanspers , Martina Summer-Kutmon , Eric Weitz , and Lars Willighagen

Activity

last edited

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Cited In

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

xenobiotics biodegradation pathway phase I biotransformation pathway via cytochrome P450

Cell Type Ontology

hepatocyte

Participants

Label Type Compact URI Comment
NADPH Metabolite chebi:16474
O2 Metabolite hmdb:HMDB0001377
Fe3+ Metabolite chebi:29034
H2O Metabolite hmdb:HMDB0002111
Substrate Metabolite wikidata:Q12119506
Substrate-OH Metabolite wikidata:Q542929
NADP+ Metabolite chebi:18009
Fe2+ Metabolite chebi:29033
NADH Metabolite chebi:16908
NAD+ Metabolite chebi:15846
CYP26A1 GeneProduct ensembl:ENSBTAG00000021118 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000095596
CYP4F11 GeneProduct ensembl:ENSBTAG00000038549 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171903
CYB5B GeneProduct ensembl:ENSBTAG00000002412 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000103018
CYP GeneProduct ensembl:ENSBTAG00000020375 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1559
CYP2C8 GeneProduct ensembl:ENSBTAG00000020375 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138115
CYP2B6 GeneProduct ensembl:ENSBTAG00000003871 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197408
CYB5R1 GeneProduct ensembl:ENSBTAG00000019927 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000159348
CYP4F22 GeneProduct ensembl:ENSBTAG00000047933 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171954
CYB5A GeneProduct ensembl:ENSBTAG00000012012 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000166347
CYP4F3 GeneProduct ensembl:ENSBTAG00000048257 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186526
CYP1B1 GeneProduct ensembl:ENSBTAG00000010531 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138061
CYP2C18 GeneProduct ensembl:ENSBTAG00000020375 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108242
CYB5R4 GeneProduct ensembl:ENSBTAG00000013591 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000065615
CYP4A22 GeneProduct ensembl:ENSBTAG00000000229 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000162365
CYB5R2 GeneProduct ensembl:ENSBTAG00000016142 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000166394
CYP11B1 GeneProduct ensembl:ENSBTAG00000004596 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160882
CYP27B1 GeneProduct ensembl:ENSBTAG00000016906 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111012
CYP2A6 GeneProduct ensembl:ENSBTAG00000047815 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000255974
CYP4F3 GeneProduct ensembl:ENSBTAG00000038549 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186529
CYP26C1 GeneProduct ensembl:ENSBTAG00000039973 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187553
CYP51A1 GeneProduct ensembl:ENSBTAG00000001992 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000001630
CYP4A11 GeneProduct ensembl:ENSBTAG00000000229 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187048
CYP2A7 GeneProduct ensembl:ENSBTAG00000047815 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198077
CYP7B1 GeneProduct ensembl:ENSBTAG00000001299 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000172817
CYP19A1 GeneProduct ensembl:ENSBTAG00000014890 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000137869
CYP3A43 GeneProduct ensembl:ENSBTAG00000047379 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000021461
CYP26B1 GeneProduct ensembl:ENSBTAG00000012212 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000003137
CYP7A1 GeneProduct ensembl:ENSBTAG00000005287 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000167910
CYP3A4 GeneProduct ensembl:ENSBTAG00000047379 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160868
CYP2W1 GeneProduct ensembl:ENSBTAG00000017701 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000073067
CYP8B1 GeneProduct ensembl:ENSBTAG00000034106 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000180432
CYP2S1 GeneProduct ensembl:ENSBTAG00000018240 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000167600
CYP39A1 GeneProduct ensembl:ENSBTAG00000003632 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000146233
CYP2R1 GeneProduct ensembl:ENSBTAG00000010419 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186104
CYP46A1 GeneProduct ensembl:ENSBTAG00000035544 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000036530
CYP4B1 GeneProduct ensembl:ENSBTAG00000011976 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000142973
CYP1A2 GeneProduct ensembl:ENSBTAG00000000085 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140505
CYP4V2 GeneProduct ensembl:ENSBTAG00000021263 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000145476
CYP2U1 GeneProduct ensembl:ENSBTAG00000012972 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000155016
CYP2J2 GeneProduct ensembl:ENSBTAG00000013693 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134716
CYP4X1 GeneProduct ensembl:ENSBTAG00000015647 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186377
CYP2E1 GeneProduct ensembl:ENSBTAG00000018365 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130649
CYP11A1 GeneProduct ensembl:ENSBTAG00000006934 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140459
CYP20A1 GeneProduct ensembl:ENSBTAG00000000851 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000119004
POR GeneProduct ensembl:ENSBTAG00000017082 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127948
CYP17A1 GeneProduct ensembl:ENSBTAG00000014335 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000148795
CYP4F2 GeneProduct ensembl:ENSBTAG00000038549 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186115
CYP3A5 GeneProduct ensembl:ENSBTAG00000047379 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106258
CYP27A1 GeneProduct ensembl:ENSBTAG00000013489 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135929
CYP2A13 GeneProduct ensembl:ENSBTAG00000047815 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197838
CYP2F1 GeneProduct ensembl:ENSBTAG00000046805 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197446
CYP2C19 GeneProduct ensembl:ENSBTAG00000020375 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000165841
CYP27C1 GeneProduct ensembl:ENSBTAG00000038275 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186684
CYB5R3 GeneProduct ensembl:ENSBTAG00000016516 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100243
CYP11B2 GeneProduct ensembl:ENSBTAG00000004596 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000179142
CYP24A1 GeneProduct ensembl:ENSBTAG00000002765 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000019186
CYP2C9 GeneProduct ensembl:ENSBTAG00000020375 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138109
CYP4F12 GeneProduct ensembl:ENSBTAG00000038549 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186204
CYP1A1 GeneProduct ensembl:ENSBTAG00000001021 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140465
MGC127055 GeneProduct ensembl:ENSBTAG00000026501 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100197
CYP3A7 GeneProduct ensembl:ENSBTAG00000047379 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160870

References

  1. Toxicology [Internet]. Niesink R, Hollinger MA, De Vries J. CRC Press; 1996. 1312 p. Available from: https://books.google.com/books/about/Toxicology.html?hl=&id=mwN9QgAACAAJ OpenLibrary Worldcat