Metabolism of alpha-linolenic acid (WP4586)

Homo sapiens

Metabolism of alpha-linolenic acid and linoleic acid to their respective acids. Both of these processes are catalyzed primarily by FADS1 and FADS2. The conversion of arachidonic acid to prostanoids is catalysed by prostaglandin G/H synthase 2 and the conversion of arachidonic acid to lipoxins is catalysed by different types of lipoxygenases.


Chris Gillissen , Egon Willighagen , Denise Slenter , Alex Pico , Kristina Hanspers , and Finterly Hu


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Homo sapiens



Pathway Ontology

eicosanoid metabolic pathway linoleic acid metabolic pathway alpha-linolenic acid metabolic pathway


Label Type Compact URI Comment
Arachidonic acid Metabolite chebi:15843
12-HETE Metabolite chebi:19138
Dihomo-gamma-linolenic acid Metabolite wikidata:Q415398
15-HEPE Metabolite hmdb:HMDB0010209
Arachidonic acid 5-hydroperoxide Metabolite chebi:91268
gamma-Linolenic acid Metabolite chebi:28661
12-HPETE Metabolite chebi:34145
12-HPEPE Metabolite wikidata:Q27148022
Linoleic acid Metabolite chebi:17351
12-HEPE Metabolite hmdb:HMDB0010202
15-HETE Metabolite chebi:63989
alpha-Linolenic acid Metabolite chebi:27432
eicosapentaenoic acid Metabolite chebi:36006
docosahexaenoic acids Metabolite chebi:36005
LXA4 Metabolite wikidata:Q27082450
LXB4 Metabolite chebi:6499
PGH2 Metabolite chebi:15554
5-HPETE Metabolite chebi:91268
PGG2 Metabolite chebi:27647
Arachidonic acid Metabolite chebi:15843
5-HETE Metabolite chebi:65341
LTA4 Metabolite chebi:15651
FADS1 Protein uniprot:O60427
FADS2 Protein uniprot:O95864
FADS2 Protein uniprot:O95864
FADS2 Protein uniprot:O95864
FADS1 Protein uniprot:O60427
Prostaglandin G/H synthase 2 Protein uniprot:P35354
5-lipoxygenase Protein uniprot:P09917
12-lipoxygenase Protein uniprot:P18054
15-lipoxygenase Protein uniprot:P16050
12-lipoxygenase Protein uniprot:P18054


  1. The Fats of Life [Internet]. Lawrence GD. 2010. 277 p. Available from: OpenLibrary Worldcat