Metabolism of alpha-linolenic acid (WP4586)
Homo sapiens
Metabolism of alpha-linolenic acid and linoleic acid to their respective acids. Both of these processes are catalyzed primarily by FADS1 and FADS2. The conversion of arachidonic acid to prostanoids is catalysed by prostaglandin G/H synthase 2 and the conversion of arachidonic acid to lipoxins is catalysed by different types of lipoxygenases.
Authors
Chris Gillissen , Egon Willighagen , Denise Slenter , Alex Pico , Kristina Hanspers , and Finterly HuActivity
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
eicosanoid metabolic pathway linoleic acid metabolic pathway alpha-linolenic acid metabolic pathway| Label | Type | Compact Identifier | Comment |
|---|---|---|---|
| Arachidonic acid | Metabolite | chebi:15843 | |
| 12-HETE | Metabolite | chebi:19138 | |
| Dihomo-gamma-linolenic acid | Metabolite | wikidata:Q415398 | |
| 15-HEPE | Metabolite | hmdb:HMDB0010209 | |
| Arachidonic acid 5-hydroperoxide | Metabolite | chebi:91268 | |
| gamma-Linolenic acid | Metabolite | chebi:28661 | |
| 12-HPETE | Metabolite | chebi:34145 | |
| 12-HPEPE | Metabolite | wikidata:Q27148022 | |
| Linoleic acid | Metabolite | chebi:17351 | |
| 12-HEPE | Metabolite | hmdb:HMDB0010202 | |
| 15-HETE | Metabolite | chebi:63989 | |
| alpha-Linolenic acid | Metabolite | chebi:27432 | |
| eicosapentaenoic acid | Metabolite | chebi:36006 | |
| docosahexaenoic acids | Metabolite | chebi:36005 | |
| LXA4 | Metabolite | wikidata:Q27082450 | |
| LXB4 | Metabolite | chebi:6499 | |
| PGH2 | Metabolite | chebi:15554 | |
| 5-HPETE | Metabolite | chebi:91268 | |
| PGG2 | Metabolite | chebi:27647 | |
| Arachidonic acid | Metabolite | chebi:15843 | |
| 5-HETE | Metabolite | chebi:65341 | |
| LTA4 | Metabolite | chebi:15651 | |
| FADS1 | Protein | uniprot:O60427 | |
| FADS2 | Protein | uniprot:O95864 | |
| FADS2 | Protein | uniprot:O95864 | |
| FADS2 | Protein | uniprot:O95864 | |
| FADS1 | Protein | uniprot:O60427 | |
| Prostaglandin G/H synthase 2 | Protein | uniprot:P35354 | |
| 5-lipoxygenase | Protein | uniprot:P09917 | |
| 12-lipoxygenase | Protein | uniprot:P18054 | |
| 15-lipoxygenase | Protein | uniprot:P16050 | |
| 12-lipoxygenase | Protein | uniprot:P18054 |
References
- Lawrence GD. The Fats of Life [Internet]. 2010. 277 p. Available from: https://books.google.com/books/about/The_Fats_of_Life.html?hl=&id=_67cmAEACAAJ OpenLibrary Worldcat