PPAR signaling pathway (WP4020)

Danio rerio

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake. Source: KEGG (http://www.genome.jp/dbget-bin/www_bget?pathway+dre03320)


Kristina Hanspers , Eric Weitz , and Egon Willighagen


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Danio rerio



Pathway Ontology

peroxisome proliferator-activated receptor signaling pathway


Label Type Compact URI Comment
saturated fatty acids Metabolite chebi:26607
unsaturated fatty acids Metabolite chebi:27208
Clofibrate Metabolite hmdb:HMDB0014774
9-cis-Retinoic acid Metabolite hmdb:HMDB0002369
eicosanoid Metabolite chebi:23899
thiazolidinediones Metabolite chebi:50864 Should be thiazolidine derivative
VLDLChylomicron Metabolite chebi:6495
NSAIDs Metabolite chebi:35475
VLDLChylomicron Metabolite chebi:6495
unsaturated fatty acids Metabolite chebi:27208
unsaturated fatty acids Metabolite chebi:27208
9-cis-Retinoic acid Metabolite hmdb:HMDB0002369
9-cis-Retinoic acid Metabolite hmdb:HMDB0002369
NSAIDs Metabolite chebi:35475
eicosanoid Metabolite chebi:23899
pparab GeneProduct zfin:ZDB-GENE-990415-211
cd36 GeneProduct zfin:ZDB-GENE-040718-55
pltp GeneProduct zfin:ZDB-GENE-040801-22
slc27a1a GeneProduct zfin:ZDB-GENE-050320-112
scd GeneProduct zfin:ZDB-GENE-031106-3
zgc:101540 GeneProduct zfin:ZDB-GENE-041212-67
slc27a4 GeneProduct zfin:ZDB-GENE-050417-248
apoa1a GeneProduct zfin:ZDB-GENE-990415-14
acox3 GeneProduct zfin:ZDB-GENE-040426-2163
slc27a6 GeneProduct zfin:ZDB-GENE-060825-27
fabp3 GeneProduct zfin:ZDB-GENE-020318-2
acadl GeneProduct zfin:ZDB-GENE-040426-771
slc27a1b GeneProduct zfin:ZDB-GENE-061013-672
angpt14 GeneProduct zfin:ZDB-GENE-041111-222
fabp2 GeneProduct zfin:ZDB-GENE-991019-5
fabp7b GeneProduct zfin:ZDB-GENE-040614-4
fabp6 GeneProduct zfin:ZDB-GENE-040625-49
fabp7a GeneProduct zfin:ZDB-GENE-000627-1
fabp1a GeneProduct zfin:ZDB-GENE-020318-3
rxrga GeneProduct zfin:ZDB-GENE-980526-36
pparab GeneProduct zfin:ZDB-GENE-990415-211
rxrga GeneProduct zfin:ZDB-GENE-980526-36
pparab GeneProduct zfin:ZDB-GENE-990415-211
rxrga GeneProduct zfin:ZDB-GENE-980526-36
fads2 GeneProduct zfin:ZDB-GENE-011212-1
cyp7a1 GeneProduct zfin:ZDB-GENE-040426-1296
cyp8b1 GeneProduct zfin:ZDB-GENE-040808-53
nr1h3 GeneProduct zfin:ZDB-GENE-050410-7
cyp27a1.4 GeneProduct zfin:ZDB-GENE-030131-1060
dbi GeneProduct zfin:ZDB-GENE-040426-1861
fabp1a GeneProduct zfin:ZDB-GENE-020318-3
fabp3 GeneProduct zfin:ZDB-GENE-020318-2
slc27a1a GeneProduct zfin:ZDB-GENE-050320-112
cd36 GeneProduct zfin:ZDB-GENE-040718-55
lpl GeneProduct zfin:ZDB-GENE-990415-139
acsbg1 GeneProduct zfin:ZDB-GENE-110914-219
acs14b GeneProduct zfin:ZDB-GENE-030131-6493
acsbg2 GeneProduct zfin:ZDB-GENE-030131-7099
acs14a GeneProduct zfin:ZDB-GENE-040426-1565
acs11b GeneProduct zfin:ZDB-GENE-040801-88
acs15 GeneProduct zfin:ZDB-GENE-040912-169
acs11a GeneProduct zfin:ZDB-GENE-050809-115
acs13b GeneProduct zfin:ZDB-GENE-030131-492
acs16 GeneProduct zfin:ZDB-GENE-030131-6776
acs13a GeneProduct zfin:ZDB-GENE-050420-181
slc27a4 GeneProduct zfin:ZDB-GENE-050417-248
slc27a1b GeneProduct zfin:ZDB-GENE-061013-672
si:dkey-91i10.3 GeneProduct zfin:ZDB-GENE-081105-124
cyp27a1.2 GeneProduct zfin:ZDB-GENE-081104-511
scdb GeneProduct zfin:ZDB-GENE-050522-12
ehhadh GeneProduct zfin:ZDB-GENE-040426-2581
cpt1aa GeneProduct zfin:ZDB-GENE-060503-925
cpt1ab GeneProduct zfin:ZDB-GENE-030131-3250
cpt2 GeneProduct zfin:ZDB-GENE-030131-6719
acaa1 GeneProduct zfin:ZDB-GENE-040704-48
scp2a GeneProduct zfin:ZDB-GENE-040426-1846
acox1 GeneProduct zfin:ZDB-GENE-041010-219
acadm GeneProduct zfin:ZDB-GENE-040426-1945
plin2 GeneProduct zfin:ZDB-GENE-050913-12
adipoqa GeneProduct zfin:ZDB-GENE-080423-2
adipoqb GeneProduct zfin:ZDB-GENE-060825-220
sorbs1 GeneProduct zfin:ZDB-GENE-090313-168
ilk GeneProduct zfin:ZDB-GENE-040426-1435
pdpk1b GeneProduct zfin:ZDB-GENE-040426-1820
si:ch211-202a12.4 GeneProduct zfin:ZDB-GENE-030131-8486
ubb GeneProduct zfin:ZDB-GENE-050411-10
ubc GeneProduct zfin:ZDB-GENE-061110-88
pck1 GeneProduct zfin:ZDB-GENE-030909-11
pck2 GeneProduct zfin:ZDB-GENE-040426-2266
aqp7 GeneProduct zfin:ZDB-GENE-030131-6461
zgc:172295 GeneProduct zfin:ZDB-GENE-080204-72


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