IL-3 signaling pathway (WP373)
Mus musculus
Interleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common beta chain, which is shared between all members of this cytokine family. Binding of IL-3 to IL3RA recruits the beta chain to the complex, which activates the JAK/STAT, MAPK and PI 3-kinase signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_15
Authors
Akhilesh Pandey , Christine Chichester , and Eric WeitzActivity
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Cited In
- Small RNA sequencing and bioinformatics analysis of RAW264.7-derived exosomes after Mycobacterium Bovis Bacillus Calmette-Guérin infection (2022).
- MicroRNAs Profiling in Murine Models of Acute and Chronic Asthma: A Relationship with mRNAs Targets (2011).
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Organisms
Mus musculusCommunities
Annotations
Pathway Ontology
interleukin-3 signaling pathwayLabel | Type | Compact URI | Comment |
---|---|---|---|
IL3 | GeneProduct | ncbigene:16187 | |
Il3ra | GeneProduct | ncbigene:16188 | |
IL3 | GeneProduct | ncbigene:16187 | |
IL3 | GeneProduct | ncbigene:16187 | |
CSF2RB | GeneProduct | ncbigene:12983 | |
Il3ra | GeneProduct | ncbigene:16188 | |
CSF2RB | GeneProduct | ncbigene:12983 | |
Pik3ca | GeneProduct | ncbigene:18706 | |
Pik3cd | GeneProduct | ncbigene:18707 | |
Hras1 | GeneProduct | ncbigene:15461 | |
Tec | GeneProduct | ncbigene:21682 | |
Vav1 | GeneProduct | ncbigene:22324 | |
Jak1 | GeneProduct | ncbigene:16451 | |
Jak2 | GeneProduct | ncbigene:16452 | |
Ptpn6 | GeneProduct | ncbigene:15170 | |
Ptpn11 | GeneProduct | ncbigene:19247 | |
Lyn | GeneProduct | ncbigene:17096 | |
Syk | GeneProduct | ncbigene:20963 | |
Hck | GeneProduct | ncbigene:15162 | |
Fyn | GeneProduct | ncbigene:14360 | |
Lck | GeneProduct | ncbigene:16818 | |
Stat1 | GeneProduct | ncbigene:20846 | |
Stat5a | GeneProduct | ncbigene:20850 | |
Stat6 | GeneProduct | ncbigene:20852 | |
Stat5b | GeneProduct | ncbigene:20851 | |
Stat3 | GeneProduct | ncbigene:20848 | |
Rara | GeneProduct | ncbigene:19401 | |
Rxra | GeneProduct | ncbigene:20181 | |
Pik3r1 | GeneProduct | ncbigene:18708 | |
Pik3r2 | GeneProduct | ncbigene:18709 | |
Akt1 | GeneProduct | ncbigene:11651 | |
Ywhaz | GeneProduct | ncbigene:22631 | |
Fes | GeneProduct | ncbigene:14159 | |
Cish | GeneProduct | ncbigene:12700 | |
Gnb2l1 | GeneProduct | ncbigene:14694 | |
Prkcb | GeneProduct | ncbigene:18751 | |
Shc1 | GeneProduct | ncbigene:20416 | |
Gm2423 | GeneProduct | ncbigene:100039786 | |
Ywhab | GeneProduct | ncbigene:54401 | |
Gab2 | GeneProduct | ncbigene:14389 | |
Grb2 | GeneProduct | ncbigene:14784 | |
Sos1 | GeneProduct | ncbigene:20662 | |
Inpp5d | GeneProduct | ncbigene:16331 | |
Gab1 | GeneProduct | ncbigene:14388 | |
Rapgef1 | GeneProduct | ncbigene:107746 | |
Crkl | GeneProduct | ncbigene:12929 | |
Cbl | GeneProduct | ncbigene:12402 | |
Crk | GeneProduct | ncbigene:12928 | |
Bad | GeneProduct | ncbigene:12015 | |
Bcl2l1 | GeneProduct | ncbigene:12048 | |
Bcl2 | GeneProduct | ncbigene:12043 | |
Bax | GeneProduct | ncbigene:12028 | |
Bcl2l11 | GeneProduct | ncbigene:12125 | |
Ppp2ca | GeneProduct | ncbigene:19052 | |
Creb1 | GeneProduct | ncbigene:12912 | |
Ptk2 | GeneProduct | ncbigene:14083 | |
Pxn | GeneProduct | ncbigene:19303 | |
Src | GeneProduct | ncbigene:20779 | |
SOCS2 | GeneProduct | ncbigene:216233 | |
Socs3 | GeneProduct | ncbigene:12702 | |
Dnm1 | GeneProduct | ncbigene:13429 | |
Vcl | GeneProduct | ncbigene:22330 | |
Raf1 | GeneProduct | ncbigene:110157 | |
Map2k1 | GeneProduct | ncbigene:26395 | |
Rac1 | GeneProduct | ncbigene:19353 | |
Rac2 | GeneProduct | ncbigene:19354 | |
Mapk8 | GeneProduct | ncbigene:26419 | |
Mapk1 | GeneProduct | ncbigene:26413 | |
Mapk3 | GeneProduct | ncbigene:26417 | |
Gata1 | GeneProduct | ncbigene:14460 | |
Gata2 | GeneProduct | ncbigene:14461 | |
Prkaca | GeneProduct | ncbigene:18747 | |
Pak1 | GeneProduct | ncbigene:18479 | |
Shc1 | GeneProduct | ncbigene:20416 | |
Prkca | GeneProduct | ncbigene:18750 | |
Prkca | GeneProduct | ncbigene:18750 | |
Nfkb1 | GeneProduct | ncbigene:18033 | |
Nfkb1 | GeneProduct | ncbigene:18033 | |
Slc2a1 | GeneProduct | ncbigene:20525 | |
Slc2a1 | GeneProduct | ncbigene:20525 | |
Bad | GeneProduct | ncbigene:12015 | |
Mapk3 | GeneProduct | ncbigene:26417 | |
Tyk2 | GeneProduct | ncbigene:54721 | |
Gsk3a | GeneProduct | ncbigene:606496 | |
Gsk3b | GeneProduct | ncbigene:56637 | |
Kcnip3 | GeneProduct | ncbigene:56461 | |
Mapk7 | GeneProduct | ncbigene:23939 | |
Foxo1 | GeneProduct | ncbigene:56458 | |
Hspb1 | GeneProduct | ncbigene:15507 | |
Mapk14 | GeneProduct | ncbigene:26416 | |
Atf2 | GeneProduct | ncbigene:11909 | |
ATF1 | GeneProduct | ncbigene:11908 | |
Mras | GeneProduct | ncbigene:17532 | |
Kras | GeneProduct | ncbigene:16653 | |
Rps6kb2 | GeneProduct | ncbigene:58988 | |
Rap1a | GeneProduct | ncbigene:109905 | |
Birc5 | GeneProduct | ncbigene:11799 | |
Mapkapk2 | GeneProduct | ncbigene:17164 | |
Sfpi1 | GeneProduct | ncbigene:20375 | |
CDC42 | GeneProduct | ncbigene:12540 | |
Bmx | GeneProduct | ncbigene:12169 | |
Tnfrsf1b | GeneProduct | ncbigene:21938 | |
Id1 | GeneProduct | ncbigene:15901 | |
Selp | GeneProduct | ncbigene:20344 | |
Fcer2a | GeneProduct | ncbigene:14128 | |
Mapk9 | GeneProduct | ncbigene:26420 | |
Chek1 | GeneProduct | ncbigene:12649 | |
Matk | GeneProduct | ncbigene:17179 | |
Mmp2 | GeneProduct | ncbigene:17390 | |
Mmp9 | GeneProduct | ncbigene:17395 | |
IL3 | GeneProduct | ncbigene:16187 |