IL-3 signaling pathway (WP373)

Mus musculus

Interleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common beta chain, which is shared between all members of this cytokine family. Binding of IL-3 to IL3RA recruits the beta chain to the complex, which activates the JAK/STAT, MAPK and PI 3-kinase signaling modules. Source: NetPath


Akhilesh Pandey , Christine Chichester , and Eric Weitz


last edited

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Mus musculus



Pathway Ontology

interleukin-3 signaling pathway


Label Type Compact URI Comment
IL3 GeneProduct ncbigene:16187
Il3ra GeneProduct ncbigene:16188
IL3 GeneProduct ncbigene:16187
IL3 GeneProduct ncbigene:16187
CSF2RB GeneProduct ncbigene:12983
Il3ra GeneProduct ncbigene:16188
CSF2RB GeneProduct ncbigene:12983
Pik3ca GeneProduct ncbigene:18706
Pik3cd GeneProduct ncbigene:18707
Hras1 GeneProduct ncbigene:15461
Tec GeneProduct ncbigene:21682
Vav1 GeneProduct ncbigene:22324
Jak1 GeneProduct ncbigene:16451
Jak2 GeneProduct ncbigene:16452
Ptpn6 GeneProduct ncbigene:15170
Ptpn11 GeneProduct ncbigene:19247
Lyn GeneProduct ncbigene:17096
Syk GeneProduct ncbigene:20963
Hck GeneProduct ncbigene:15162
Fyn GeneProduct ncbigene:14360
Lck GeneProduct ncbigene:16818
Stat1 GeneProduct ncbigene:20846
Stat5a GeneProduct ncbigene:20850
Stat6 GeneProduct ncbigene:20852
Stat5b GeneProduct ncbigene:20851
Stat3 GeneProduct ncbigene:20848
Rara GeneProduct ncbigene:19401
Rxra GeneProduct ncbigene:20181
Pik3r1 GeneProduct ncbigene:18708
Pik3r2 GeneProduct ncbigene:18709
Akt1 GeneProduct ncbigene:11651
Ywhaz GeneProduct ncbigene:22631
Fes GeneProduct ncbigene:14159
Cish GeneProduct ncbigene:12700
Gnb2l1 GeneProduct ncbigene:14694
Prkcb GeneProduct ncbigene:18751
Shc1 GeneProduct ncbigene:20416
Gm2423 GeneProduct ncbigene:100039786
Ywhab GeneProduct ncbigene:54401
Gab2 GeneProduct ncbigene:14389
Grb2 GeneProduct ncbigene:14784
Sos1 GeneProduct ncbigene:20662
Inpp5d GeneProduct ncbigene:16331
Gab1 GeneProduct ncbigene:14388
Rapgef1 GeneProduct ncbigene:107746
Crkl GeneProduct ncbigene:12929
Cbl GeneProduct ncbigene:12402
Crk GeneProduct ncbigene:12928
Bad GeneProduct ncbigene:12015
Bcl2l1 GeneProduct ncbigene:12048
Bcl2 GeneProduct ncbigene:12043
Bax GeneProduct ncbigene:12028
Bcl2l11 GeneProduct ncbigene:12125
Ppp2ca GeneProduct ncbigene:19052
Creb1 GeneProduct ncbigene:12912
Ptk2 GeneProduct ncbigene:14083
Pxn GeneProduct ncbigene:19303
Src GeneProduct ncbigene:20779
SOCS2 GeneProduct ncbigene:216233
Socs3 GeneProduct ncbigene:12702
Dnm1 GeneProduct ncbigene:13429
Vcl GeneProduct ncbigene:22330
Raf1 GeneProduct ncbigene:110157
Map2k1 GeneProduct ncbigene:26395
Rac1 GeneProduct ncbigene:19353
Rac2 GeneProduct ncbigene:19354
Mapk8 GeneProduct ncbigene:26419
Mapk1 GeneProduct ncbigene:26413
Mapk3 GeneProduct ncbigene:26417
Gata1 GeneProduct ncbigene:14460
Gata2 GeneProduct ncbigene:14461
Prkaca GeneProduct ncbigene:18747
Pak1 GeneProduct ncbigene:18479
Shc1 GeneProduct ncbigene:20416
Prkca GeneProduct ncbigene:18750
Prkca GeneProduct ncbigene:18750
Nfkb1 GeneProduct ncbigene:18033
Nfkb1 GeneProduct ncbigene:18033
Slc2a1 GeneProduct ncbigene:20525
Slc2a1 GeneProduct ncbigene:20525
Bad GeneProduct ncbigene:12015
Mapk3 GeneProduct ncbigene:26417
Tyk2 GeneProduct ncbigene:54721
Gsk3a GeneProduct ncbigene:606496
Gsk3b GeneProduct ncbigene:56637
Kcnip3 GeneProduct ncbigene:56461
Mapk7 GeneProduct ncbigene:23939
Foxo1 GeneProduct ncbigene:56458
Hspb1 GeneProduct ncbigene:15507
Mapk14 GeneProduct ncbigene:26416
Atf2 GeneProduct ncbigene:11909
ATF1 GeneProduct ncbigene:11908
Mras GeneProduct ncbigene:17532
Kras GeneProduct ncbigene:16653
Rps6kb2 GeneProduct ncbigene:58988
Rap1a GeneProduct ncbigene:109905
Birc5 GeneProduct ncbigene:11799
Mapkapk2 GeneProduct ncbigene:17164
Sfpi1 GeneProduct ncbigene:20375
CDC42 GeneProduct ncbigene:12540
Bmx GeneProduct ncbigene:12169
Tnfrsf1b GeneProduct ncbigene:21938
Id1 GeneProduct ncbigene:15901
Selp GeneProduct ncbigene:20344
Fcer2a GeneProduct ncbigene:14128
Mapk9 GeneProduct ncbigene:26420
Chek1 GeneProduct ncbigene:12649
Matk GeneProduct ncbigene:17179
Mmp2 GeneProduct ncbigene:17390
Mmp9 GeneProduct ncbigene:17395
IL3 GeneProduct ncbigene:16187