Myometrial relaxation and contraction pathways (WP140)

Rattus norvegicus

Open in new tab
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
This pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile activity is the myometrium. Genes in this pathway are either transcribed in myometrial muscle cells or act upon the myometrium to regulate contraction. The left half of this pathway illustrates pathways of myometrial relaxation that are active throughout normal gestation. These signaling events act to suppress coordinated contractions to prevent the early onset of labor at term, largely via activation of the adenylyl-cyclase thrhough G-protein coupled receptors. On the right side of this pathway are signaling componets involved in the activation of uterine contractions at labor, in particular, activation of calcium mobilization via Oxytocin mediated binding to the Oxytocin G-protein coupled receptor. Additional genes implicated in this pathway, based on microarray expression profiling of gestation, term and postpartum of term mice are also included (e.g., Guca2b, Rdc1, Edg2) have also been included. For a detailed description of this pathway see: http://genomebiology.com/2005/6/2/R12.

Authors

Nathan Salomonis , Thomas Kelder , Kristina Hanspers , Elisa Cirillo , Martina Summer-Kutmon , Lauren J. Dupuis , Eric Weitz , and Alex Pico

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Rattus norvegicus

Communities

Annotations

Pathway Ontology

signaling pathway

Cell Type Ontology

smooth muscle cell

Participants

Label Type Compact URI Comment
ATP Metabolite cas:1927-31-7
Cyclic AMP Metabolite hmdb:HMDB0000058
ADP Metabolite cas:58-64-0
Cyclic GMP Metabolite hmdb:HMDB0001314
ADP Metabolite cas:58-64-0
ATP Metabolite cas:1927-31-7
Cyclic AMP Metabolite hmdb:HMDB0000058
Ramp1 GeneProduct ensembl:ENSRNOG00000019926 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10267
Igfbp6 GeneProduct ensembl:ENSRNOG00000010977 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3489
Gng13 GeneProduct ensembl:ENSRNOG00000039350 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:51764
Prkcz GeneProduct ensembl:ENSRNOG00000015480 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5590
Adcy5 GeneProduct ensembl:ENSRNOG00000002229 There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:111
Ryr1 GeneProduct ensembl:ENSRNOG00000020557 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6261
Atp2a3 GeneProduct ensembl:ENSRNOG00000017912 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:489
Atf4 GeneProduct ensembl:ENSRNOG00000017801 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:468
Prkar2b GeneProduct ensembl:ENSRNOG00000009079 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5577
Prkcg GeneProduct ensembl:ENSRNOG00000054371 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5582
Adcy2 GeneProduct ensembl:ENSRNOG00000032150 There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:108
Prkce GeneProduct ensembl:ENSRNOG00000015603 This EST is listed on the Affymetrix Murine6500 chip. The SwissProt entry name is KPCE MOUSE.
Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5581
Igfbp5 GeneProduct ensembl:ENSRNOG00000017206 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3488
Grk4 GeneProduct ensembl:ENSRNOG00000011847 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2868
Gnb3 GeneProduct ensembl:ENSRNOG00000015541 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2784
Gng3 GeneProduct ensembl:ENSRNOG00000019570 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2785
Pkib GeneProduct ensembl:ENSRNOG00000000811 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5570
Fos GeneProduct ensembl:ENSRNOG00000008015 PMID: 10218980 PMID: 7628395 [
Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2353
Grk5 GeneProduct ensembl:ENSRNOG00000011439 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2869
Oxtr GeneProduct ensembl:ENSRNOG00000005806 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5021
Mylk2 GeneProduct ensembl:ENSRNOG00000008235 KML2 MOUSE
Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:85366
Gng12 GeneProduct ensembl:ENSRNOG00000050231 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:55970
Rgs2 GeneProduct ensembl:ENSRNOG00000003687 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5997
Gng2 GeneProduct ensembl:ENSRNOG00000048980 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:54331
Rgs6 GeneProduct ensembl:ENSRNOG00000008082 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9628
Jun GeneProduct ensembl:ENSRNOG00000026293 PMID: 10218980
Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3725
Adcy3 GeneProduct ensembl:ENSRNOG00000003999 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:109
Gng7 GeneProduct ensembl:ENSRNOG00000019857 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2788
Prkacb GeneProduct ensembl:ENSRNOG00000004978 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5567
Atf6b GeneProduct ensembl:ENSRNOG00000000431 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1388
Ramp2 GeneProduct ensembl:ENSRNOG00000020415 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10266
Gpr182 GeneProduct ensembl:ENSRNOG00000004311 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:11318
Calca GeneProduct ensembl:ENSRNOG00000011130 CRF HUMAN PMID: 11854458
Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:796
Adcy8 GeneProduct ensembl:ENSRNOG00000004890 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:114
Adcy1 GeneProduct ensembl:ENSRNOG00000059479 CYA1 HUMAN
Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:107
Arrb2 GeneProduct ensembl:ENSRNOG00000019308 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:409
Atf1 GeneProduct ensembl:ENSRNOG00000061088 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:466
Nos1 GeneProduct ensembl:ENSRNOG00000001130 PMID: 11854458
Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4842
Grk5 GeneProduct ensembl:ENSRNOG00000011439 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2869
Rgs17 GeneProduct ensembl:ENSRNOG00000018690 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:26575
Prkch GeneProduct ensembl:ENSRNOG00000004873 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5583
Ryr2 GeneProduct ensembl:ENSRNOG00000017060 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6262
Rgs18 GeneProduct ensembl:ENSRNOG00000003959 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:64407
Ywhab GeneProduct ensembl:ENSRNOG00000010945 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7529
Il6 GeneProduct ensembl:ENSRNOG00000010278 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3569
Grk6 GeneProduct ensembl:ENSRNOG00000014615 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2870
Crcp GeneProduct ensembl:ENSRNOG00000000901 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:27297
Rxfp1 GeneProduct ensembl:ENSRNOG00000024120 PMID: 11809971
Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:59350
Cnn1 GeneProduct ensembl:ENSRNOG00000027736 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1264
Ywhah GeneProduct ensembl:ENSRNOG00000055471 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7533
Camk2g GeneProduct ensembl:ENSRNOG00000009783 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:818
Rgs7 GeneProduct ensembl:ENSRNOG00000021984 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6000
Myl4 GeneProduct ensembl:ENSRNOG00000050675 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4635
Rgs1 GeneProduct ensembl:ENSRNOG00000003895 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5996
Prkcb GeneProduct ensembl:ENSRNOG00000012061 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5579
Mylk2 GeneProduct ensembl:ENSRNOG00000008235 KML2 MOUSE
Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:85366
Lpar1 GeneProduct ensembl:ENSRNOG00000013656 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1902
Ramp3 GeneProduct ensembl:ENSRNOG00000053766 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10268
Camk2d GeneProduct ensembl:ENSRNOG00000011589 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:817
Prkcq GeneProduct ensembl:ENSRNOG00000019057 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5588
Nos3 GeneProduct ensembl:ENSRNOG00000009348 PMID: 11854458
Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4846
Cald1 GeneProduct ensembl:ENSRNOG00000010233 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:800
Gsto1 GeneProduct ensembl:ENSRNOG00000028746 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9446
Crh GeneProduct ensembl:ENSRNOG00000012703 CRF HUMAN PMID: 11854458
Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1392
Prkca GeneProduct ensembl:ENSRNOG00000003491 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5578
Grk4 GeneProduct ensembl:ENSRNOG00000011847 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2868
Cnn2 GeneProduct ensembl:ENSRNOG00000043044 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1265
Prkar2a GeneProduct ensembl:ENSRNOG00000020284 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5576
Arrb2 GeneProduct ensembl:ENSRNOG00000019308 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:409
Gnb2 GeneProduct ensembl:ENSRNOG00000001409 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2783
Gng11 GeneProduct ensembl:ENSRNOG00000047914 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2791
Oxtr GeneProduct ensembl:ENSRNOG00000005806 Sladek SM, Westerhausen-Larson A, Roberts JM. PMID: 10377025
Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5021
Igfbp4 GeneProduct ensembl:ENSRNOG00000010635 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3487
Ryr3 GeneProduct ensembl:ENSRNOG00000006645 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6263
Rgs10 GeneProduct ensembl:ENSRNOG00000042592 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6001
Dgkz GeneProduct ensembl:ENSRNOG00000017737 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8525
Rgs5 GeneProduct ensembl:ENSRNOG00000002730 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8490
Atp2a2 GeneProduct ensembl:ENSRNOG00000001285 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:488
Igfbp2 GeneProduct ensembl:ENSRNOG00000016957 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3485
Rgs20 GeneProduct ensembl:ENSRNOG00000008100 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8601
Gnaq GeneProduct ensembl:ENSRNOG00000014183 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2776
Gnb5 GeneProduct ensembl:ENSRNOG00000047799 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10681
Ywhae GeneProduct ensembl:ENSRNOG00000005290 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7531
Oxt GeneProduct ensembl:ENSRNOG00000021225 MGI:97453
Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5020
Prkar1a GeneProduct ensembl:ENSRNOG00000049876 KAP0 HUMAN
Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5573
Rgs9 GeneProduct ensembl:ENSRNOG00000003800 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8787
Sfn GeneProduct ensembl:ENSRNOG00000033153 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2810
Adcy7 GeneProduct ensembl:ENSRNOG00000014776 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:113
Atf5 GeneProduct ensembl:ENSRNOG00000020060 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:22809
Plcg2 GeneProduct ensembl:ENSRNOG00000051986 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5336
Il1b GeneProduct ensembl:ENSRNOG00000004649 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3553
Gng5 GeneProduct ensembl:ENSRNOG00000038205 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2787
Adm GeneProduct ensembl:ENSRNOG00000027030 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:133
Rgs16 GeneProduct ensembl:ENSRNOG00000027024 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6004
Itpr3 GeneProduct ensembl:ENSRNOG00000052795 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3710
Prkd1 GeneProduct ensembl:ENSRNOG00000004165 KPCM HUMAN
Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5587
LOC100361457 GeneProduct ensembl:ENSRNOG00000036701 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:71
Gng8 GeneProduct ensembl:ENSRNOG00000016701 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:94235
Rxfp2 GeneProduct ensembl:ENSRNOG00000000897 PMID: 11809971 LGR8 MOUSE
Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:122042
Gnb4 GeneProduct ensembl:ENSRNOG00000011070 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:59345
Prkar1b GeneProduct ensembl:ENSRNOG00000028733 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5575
Rgs19 GeneProduct ensembl:ENSRNOG00000016547 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10287
Actb GeneProduct ensembl:ENSRNOG00000034254 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:60
Corin GeneProduct ensembl:ENSRNOG00000002302 MGI:97367
Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10699
Gabpb1l GeneProduct ensembl:ENSRNOG00000053439 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2553
Prkcd GeneProduct ensembl:ENSRNOG00000016346 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5580
Sp1 GeneProduct ensembl:ENSRNOG00000014084 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6667
Gabpa GeneProduct ensembl:ENSRNOG00000053205 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2551
Adcy6 GeneProduct ensembl:ENSRNOG00000054757 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:112
Guca2a GeneProduct ensembl:ENSRNOG00000008849 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2980
Itpr1 GeneProduct ensembl:ENSRNOG00000007104 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3708
Camk2b GeneProduct ensembl:ENSRNOG00000052080 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:816
Crhr1 GeneProduct ensembl:ENSRNOG00000004900 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1394
Rln1 GeneProduct ensembl:ENSRNOG00000060867 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6013
Pde4d GeneProduct ensembl:ENSRNOG00000042536 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5144
Grk6 GeneProduct ensembl:ENSRNOG00000014615 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2870
Ets2 GeneProduct ensembl:ENSRNOG00000001647 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2114
Atf3 GeneProduct ensembl:ENSRNOG00000003745 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:467
Adcy4 GeneProduct ensembl:ENSRNOG00000020401 There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:196883
Plcd1 GeneProduct ensembl:ENSRNOG00000032238 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5333
Rgs4 GeneProduct ensembl:ENSRNOG00000002773 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5999
Rgs14 GeneProduct ensembl:ENSRNOG00000015616 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10636
Slc8a1 GeneProduct ensembl:ENSRNOG00000008479 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6546
Guca2b GeneProduct ensembl:ENSRNOG00000008979 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2981
Arrb1 GeneProduct ensembl:ENSRNOG00000030404 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:408
Gja1 GeneProduct ensembl:ENSRNOG00000000805 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2697
Arrb1 GeneProduct ensembl:ENSRNOG00000030404 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:408
Ywhag GeneProduct ensembl:ENSRNOG00000001436 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7532
Cacnb3 GeneProduct ensembl:ENSRNOG00000054274 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:784
Ackr3 GeneProduct ensembl:ENSRNOG00000019622 PMID: 10614663
Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:57007
Igfbp1 GeneProduct ensembl:ENSRNOG00000058780 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3484
Pkig GeneProduct ensembl:ENSRNOG00000010235 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:11142
Pde4b GeneProduct ensembl:ENSRNOG00000005905 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5142
Gngt1 GeneProduct ensembl:ENSRNOG00000010546 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2792
Pkia GeneProduct ensembl:ENSRNOG00000012095 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5569
Ywhaq GeneProduct ensembl:ENSRNOG00000051650 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10971
Creb3 GeneProduct ensembl:ENSRNOG00000016452 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10488
Actc1 GeneProduct ensembl:ENSRNOG00000008536 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:70
Igfbp3 GeneProduct ensembl:ENSRNOG00000061910 Relaxin is a member of the Insulin Growth Factor family of proteins. IGFBP-3 binds IGFII preferentially. (SwissProt).
Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3486
Plcg1 GeneProduct ensembl:ENSRNOG00000051490 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5335
Maff GeneProduct ensembl:ENSRNOG00000012886 OMIM: Inoue et al. (1994) demonstrated that the US-2 element in the promoter of the human oxytocin receptor gene (OXTR; 167055) binds specifically nuclear proteins from human myometrium at parturition. Using the US-2 element in a yeast 1-hybrid system to screen a human myometrium cDNA library, Kimura et al. (1999) isolated a full-length cDNA encoding the homolog of chicken MafF. Human MAFF encodes a deduced 164-amino acid protein with a predicted molecular mass of 17.8 kD. Like other small MAF proteins (e.g., MAFG, 602020), it contains an extended leucine zipper structure and lacks an N-terminal transactivating domain. Northern blot analysis showed a strong 2.6-kb signal in mRNA from term myometrium and from kidney, but not from nonpregnant myometrium. The MAFF protein is also preferentially expressed in term myometrium. The authors concluded that MAFF plays a role in OXTR gene upregulation at term.
Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:23764
Atf2 GeneProduct ensembl:ENSRNOG00000001597 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1386
Gng4 GeneProduct ensembl:ENSRNOG00000047080 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2786
Adcy9 GeneProduct ensembl:ENSRNOG00000049768 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:115
AABR07013776.1 GeneProduct ensembl:ENSRNOG00000048082 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:801
Acta1 GeneProduct ensembl:ENSRNOG00000017786 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:58
Gnb1 GeneProduct ensembl:ENSRNOG00000016638 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2782
Myl2 GeneProduct ensembl:ENSRNOG00000030848 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4633
Rgs3 GeneProduct ensembl:ENSRNOG00000024501 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5998
AABR07062512.1 GeneProduct ensembl:ENSRNOG00000053339 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3709
Plcb3 GeneProduct ensembl:ENSRNOG00000021150 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5331
Camk2a GeneProduct ensembl:ENSRNOG00000018712 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:815
Nfkb1 GeneProduct ensembl:ENSRNOG00000023258 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4790
Creb1 GeneProduct ensembl:ENSRNOG00000013412 Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1385
Gucy1a3 GeneProduct ensembl:ENSRNOG00000012302 PMID: 11854458
Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2982

References

  1. Is up-regulation of phosphodiesterase 4 activity by PGE2 involved in the desensitization of beta-mimetics in late pregnancy human myometrium? Méhats C, Tanguy G, Dallot E, Cabrol D, Ferré F, Leroy MJ. J Clin Endocrinol Metab. 2001 Nov;86(11):5358–65. PubMed Europe PMC Scholia
  2. Up-regulation of nitric oxide synthase and modulation of the guanylate cyclase activity by corticotropin-releasing hormone but not urocortin II or urocortin III in cultured human pregnant myometrial cells. Aggelidou E, Hillhouse EW, Grammatopoulos DK. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3300–5. PubMed Europe PMC Scholia
  3. Identifying genetic networks underlying myometrial transition to labor. Salomonis N, Cotte N, Zambon AC, Pollard KS, Vranizan K, Doniger SW, et al. Genome Biol. 2005;6(2):R12. PubMed Europe PMC Scholia