Kit receptor signaling pathway (WP1121)

Canis familiaris

Kit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets among others. Binding of Kit receptor to stem cell factor leads to an intracellular cascade of events that includes activation of PI 3-kinase, Src family kinases and PLC gamma. Activating mutations in the Kit receptor are associated with several human malignancies include leukemias, gastrointestinal stromal tumors and mastocytomas. Source: NetPath


Alex Pico , Daniela Digles , and Eric Weitz


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Canis familiaris



Pathway Ontology

Stem Cell Factor signaling pathway


Label Type Compact URI Comment
GRB7 GeneProduct ncbigene:491021
PIK3R1 GeneProduct ncbigene:487235
PIK3R2 GeneProduct ncbigene:609956
SHC1 GeneProduct ncbigene:490439
CSF2RB GeneProduct ncbigene:481276
GRB2 GeneProduct ncbigene:483312
SOCS6 GeneProduct ncbigene:476171
SOCS5 GeneProduct ncbigene:474581
CISH GeneProduct ncbigene:484757
CLTC GeneProduct ncbigene:480578
SRC GeneProduct ncbigene:485864
PLCE1 GeneProduct ncbigene:486808
JAK2 GeneProduct ncbigene:484185
GRAP GeneProduct ncbigene:489534
PTPRU GeneProduct ncbigene:487328
STAP1 GeneProduct ncbigene:482171
PRKCA GeneProduct ncbigene:490904
PLCG1 GeneProduct ncbigene:485874
STAT1 GeneProduct ncbigene:488449
STAT5A GeneProduct ncbigene:490968
STAT5B GeneProduct ncbigene:490969
PIK3CG GeneProduct ncbigene:483266
SH2B2 GeneProduct ncbigene:489820
AKT1 GeneProduct ncbigene:490878
TEC GeneProduct ncbigene:482140
LYN GeneProduct ncbigene:477886
DOK1 GeneProduct ncbigene:483100
PTPN6 GeneProduct ncbigene:486717
PTPN11 GeneProduct ncbigene:477488
EPOR GeneProduct ncbigene:484943
RPS6KA1 GeneProduct ncbigene:487353
MITF GeneProduct ncbigene:415126
MAPK1 GeneProduct ncbigene:477575
ABL1 GeneProduct ncbigene:491292
FGR GeneProduct ncbigene:487341
HCK GeneProduct ncbigene:485828
YES1 GeneProduct ncbigene:490532
RASA1 GeneProduct ncbigene:479158
FES GeneProduct ncbigene:609483
CRKL GeneProduct ncbigene:608125
SOCS1 GeneProduct ncbigene:490006
VAV1 GeneProduct ncbigene:485016
VAV2 GeneProduct ncbigene:608060
MATK GeneProduct ncbigene:611999
BAD GeneProduct ncbigene:483763
SOS1 GeneProduct ncbigene:483042
FYN GeneProduct ncbigene:475032
PRKCB GeneProduct ncbigene:489968
RAF1 GeneProduct ncbigene:484648
SPRED2 GeneProduct ncbigene:481397
SPRED1 GeneProduct ncbigene:487485
SH3KBP1 GeneProduct ncbigene:612797
CBLB GeneProduct ncbigene:487965
BTK GeneProduct ncbigene:492019
KIT GeneProduct ncbigene:403811
KITLG GeneProduct ncbigene:403507
KIT GeneProduct ncbigene:403811
KITLG GeneProduct ncbigene:403507
MAP2K1 GeneProduct ncbigene:478347
STAT3 GeneProduct ncbigene:490967
MPDZ GeneProduct ncbigene:474708
DOK1 GeneProduct ncbigene:483100