Hypothetical craniofacial development pathway (WP3655)

Homo sapiens

Hypothetical pathway linking cranio-facial development pathway (IRF6, TP63, TFAP2A, and TGFB3) to Rho signaling pathway through ARHGAP29 regulation. Authors of literature suspect that a decrease of ARHGAP29 concentration would result in more active form, Rho-GTP, which would down-regulate cranio-facial development genes. An implication of this active Rho-GTP may be the formation of cleft lip. This pathway is based on figure 4 from Leslie et al.


AAR&Co , Eric Weitz , and Kristina Hanspers


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Homo sapiens



Pathway Ontology

signaling pathway signaling pathway pertinent to development

Disease Ontology

cleft lip


Label Type Compact URI Comment
GTP Metabolite hmdb:HMDB0001440
GDP Metabolite hmdb:HMDB0000960
RHOA GeneProduct hgnc.symbol:RHOA
ARHGAP29 GeneProduct hgnc.symbol:ARHGAP29
IRF6 GeneProduct hgnc.symbol:IRF6
GEF GeneProduct hgnc.symbol:ARHGEF2
TFAP2A GeneProduct hgnc.symbol:TFAP2A
TP63 GeneProduct hgnc.symbol:TP63
RHOA GeneProduct hgnc.symbol:RHOA
TGFB3 GeneProduct hgnc.symbol:TGFB3


  1. Expression and mutation analyses implicate ARHGAP29 as the etiologic gene for the cleft lip with or without cleft palate locus identified by genome-wide association on chromosome 1p22. Leslie EJ, Mansilla MA, Biggs LC, Schuette K, Bullard S, Cooper M, et al. Birth Defects Res A Clin Mol Teratol. 2012 Nov;94(11):934–42. PubMed Europe PMC Scholia