Sulindac metabolic pathway (WP2542)

Homo sapiens

Metabolism of sulindac sulfide is catalyzed by MsrA, MsrB2, and MsrB3.


Egon Willighagen , Marianthi Kalafati , Martina Summer-Kutmon , Max Van Son , Denise Slenter , and Eric Weitz


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Homo sapiens



Pathway Ontology

classic metabolic pathway xenobiotic metabolic pathway


Label Type Compact URI Comment
Sulindac-S Metabolite pubchem.compound:11245227
Sulfindac sulfide Metabolite chemspider:4509492
Sulindac-R Metabolite pubchem.compound:16046677
Sulindac sulfone Metabolite chemspider:4582441 The structure for the sulfone in the paper is inconsistent with the entries in ChemSpider and PubChem; I assume the paper made typographic errors.
MsrA GeneProduct ensembl:ENSG00000175806
FMO GeneProduct interpro:IPR000960
MsrB2 GeneProduct ensembl:ENSG00000148450
CYP1B1 GeneProduct ensembl:ENSG00000138061
MsrB3 GeneProduct ensembl:ENSG00000174099
CYP1A2 GeneProduct ensembl:ENSG00000140505
CYP1A2 GeneProduct ensembl:ENSG00000140505


  1. Studies on the metabolism and biological activity of the epimers of sulindac. Brunell D, Sagher D, Kesaraju S, Brot N, Weissbach H. Drug Metab Dispos. 2011 Jun;39(6):1014–21. PubMed Europe PMC Scholia