Insulin signaling in adipocytes (normal condition) (WP3634)

Homo sapiens

The paper (1) describes insulin signalling in human adipocytes under normal and diabetic states using mathematical models based on experimental data. This model corresponds to insulin signalling under normal conditions. Insulin signalling under diabetic condition is represented in WP3635. The model has been converted to GPML using the PathSBML plugin from PathVIsio, importing the model BIOMD0000000448 from the BioModels Database directly. The layout has been improved manually. Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Anwesha Bohler , Kristina Hanspers , Andika Tan , Egon Willighagen , Ryan Miller , Chris Evelo , and Eric Weitz


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Homo sapiens



Cell Type Ontology

fat cell

Pathway Ontology

insulin signaling pathway


Label Type Compact URI Comment
X Metabolite chebi:36080 inactive feedback protein
X Metabolite kegg.compound:C00562 active feedback protein
insulin Metabolite chebi:5931
P Metabolite chebi:28659
P Metabolite chebi:28659
insulin Metabolite chebi:5931
AS160p GeneProduct pato:PATO:0002220
AS160 Protein uniprot:O60343
GLUT4 Protein uniprot:P14672
GLUT4m Protein uniprot:P14672
INSR Protein uniprot:P06213 Inactive, plasma membrane
IRS1 Protein uniprot:P35568
IRS1307 Protein uniprot:P35568
IRS1p Protein uniprot:P35568
IRS1p307 Protein uniprot:P35568
INSR Protein uniprot:P06213 Inactive, internalized
INSR Protein uniprot:P06213 insulin bound
INSR Protein uniprot:P06213 internalized and tyrosine phosphorylated
INSR Protein uniprot:P06213 Tyrosine phosphorylated
PKB Protein uniprot:P31751
PKB308p Protein uniprot:P31751
PKB308p473p Protein uniprot:P31751
PKB473p Protein uniprot:P31751
S6 Protein uniprot:P62753
S6K Protein uniprot:P23443
S6Kp Protein uniprot:P23443
S6p Protein uniprot:P62753
mTORC1 Protein uniprot:P42345
mTORC1a Protein uniprot:P42345
mTORC2 Protein uniprot:P42345
mTORC2a Protein uniprot:P42345


  1. Insulin signaling in type 2 diabetes: experimental and modeling analyses reveal mechanisms of insulin resistance in human adipocytes. Brännmark C, Nyman E, Fagerholm S, Bergenholm L, Ekstrand EM, Cedersund G, et al. J Biol Chem. 2013 Apr 5;288(14):9867–80. PubMed Europe PMC Scholia