Endothelin pathways (WP2197)
Homo sapiens
Endothelin-1 is a bicyclic 21 amino acid peptide, produced primarily in the endothelium. It is a potent stimulus of long-lasting and persistent vasoconstriction. It also has a role as a stimulus of inflammation, oxidative stress and cellular proliferation. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2197 CPTAC Assay Portal]
Authors
Sabine Daemen , Mireille Sthijns , Egon Willighagen , Kristina Hanspers , Christine Chichester , Alex Pico , Martina Summer-Kutmon , Lauren J. Dupuis , and Eric WeitzActivity
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Cited In
- Identification of biomarkers and pathways for the SARS-CoV-2 infections that make complexities in pulmonary arterial hypertension patients (2021).
- Identification of the effects of COVID-19 on patients with pulmonary fibrosis and lung cancer: a bioinformatics analysis and literature review (2022).
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Organisms
Homo sapiensCommunities
Renal Genomics PathwaysAnnotations
Cell Type Ontology
blood vessel endothelial cell smooth muscle cellPathway Ontology
G protein mediated signaling pathway via Galphaq family Ras superfamily mediated signaling pathway G protein mediated signaling pathway via Galphai family G protein mediated signaling pathway via Galphas family endothelin signaling pathway calcium/calmodulin dependent signaling pathwayDisease Ontology
benign essential hypertension hypertension| Label | Type | Compact URI | Comment |
|---|---|---|---|
| GTP | Metabolite | hmdb:HMDB0001440 | |
| L-Arginine | Metabolite | hmdb:HMDB0000517 | |
| K+ | Metabolite | hmdb:HMDB0000586 | |
| cGMP | Metabolite | hmdb:HMDB0001314 | |
| K+ | Metabolite | hmdb:HMDB0000586 | |
| NO | Metabolite | hmdb:HMDB0003378 | |
| ATP | Metabolite | hmdb:HMDB0001532 | |
| cAMP | Metabolite | hmdb:HMDB0000058 | |
| Citrulline | Metabolite | hmdb:HMDB0000904 | |
| Arachidonic acid | Metabolite | hmdb:HMDB0001043 | |
| PGI2 | Metabolite | wikidata:Q412050 | |
| IP3 | Metabolite | hmdb:HMDB0001059 | |
| DAG | Metabolite | hmdb:HMDB0007008 | |
| Ca2+ | Metabolite | hmdb:HMDB0000464 | |
| PIP2 | Metabolite | hmdb:HMDB0010032 | |
| Ca2+ | Metabolite | hmdb:HMDB0000464 | |
| Ca2+ | Metabolite | hmdb:HMDB0000464 | |
| PIP2 | Metabolite | hmdb:HMDB0010032 | |
| IP3 | Metabolite | hmdb:HMDB0001059 | |
| DAG | Metabolite | hmdb:HMDB0007008 | |
| Ca2+ | Metabolite | hmdb:HMDB0000464 | |
| Ca2+ | Metabolite | hmdb:HMDB0000464 | |
| NO | Metabolite | hmdb:HMDB0003378 | |
| PGI2 | Metabolite | wikidata:Q412050 | |
| Ca2+ | Metabolite | hmdb:HMDB0000464 | |
| K+ | Metabolite | hmdb:HMDB0000586 | |
| K+ | Metabolite | hmdb:HMDB0000586 | |
| K+ | Metabolite | hmdb:HMDB0000586 | |
| K+ | Metabolite | hmdb:HMDB0000586 | |
| NO | Metabolite | hmdb:HMDB0003378 | |
| NO | Metabolite | hmdb:HMDB0003378 | |
| Ca2+ | Metabolite | hmdb:HMDB0000464 | |
| RAMP1 | GeneProduct | ensembl:ENSG00000132329 | |
| Y1 | GeneProduct | ensembl:ENSG00000164128 | |
| CGRP | GeneProduct | ensembl:ENSG00000110680 | |
| sGC | GeneProduct | ensembl:ENSG00000123201 | |
| SERCA | GeneProduct | ensembl:ENSG00000174437 | |
| PKA | GeneProduct | ensembl:ENSG00000178796 | |
| AC | GeneProduct | ensembl:ENSG00000143199 | adenylate cyclase |
| COX2 | GeneProduct | ncbigene:4513 | |
| a adrenergic receptor | GeneProduct | ensembl:ENSG00000120907 | |
| NPY | GeneProduct | ensembl:ENSG00000122585 | |
| CRLR | GeneProduct | ensembl:ENSG00000064989 | |
| IP1 | GeneProduct | ensembl:ENSG00000160013 | Prostaglandin I2 Receptor |
| eNOS | GeneProduct | ensembl:ENSG00000164867 | |
| Endothelin 1 | GeneProduct | ensembl:ENSG00000078401 | |
| ECE | GeneProduct | ensembl:ENSG00000117298 | |
| Cap | GeneProduct | ensembl:ENSG00000130176 | Calponin; tonically inhibits the ATPase activity of myosin in smooth muscleType your comment here |
| PKC | GeneProduct | ensembl:ENSG00000154229 | |
| GaQ | GeneProduct | ensembl:ENSG00000060558 | |
| MLC | GeneProduct | ensembl:ENSG00000168530 | myosine light chain |
| MEK | GeneProduct | ensembl:ENSG00000169032 | |
| EDNRA | GeneProduct | ensembl:ENSG00000151617 | |
| MLCK | GeneProduct | ensembl:ENSG00000065534 | |
| ERK1/2 | GeneProduct | ensembl:ENSG00000100030 | |
| EDNRB | GeneProduct | ensembl:ENSG00000136160 | |
| RAF | GeneProduct | ensembl:ENSG00000132155 | |
| PLCb | GeneProduct | ensembl:ENSG00000182621 | |
| CAD | GeneProduct | ensembl:ENSG00000084774 | Calmodulin binding protein; tonically inhibits the ATPase activity of myosin in smoothe muscle; mediating factor for Ca2+ dependent inhibition of smooth muscle contractionType your comment here |
| CaM | GeneProduct | ensembl:ENSG00000198668 | |
| Endothelin 1 | GeneProduct | ensembl:ENSG00000078401 | |
| GbQ | GeneProduct | ensembl:ENSG00000069966 | |
| GgQ | GeneProduct | ensembl:ENSG00000127588 | |
| EDNRB | GeneProduct | ensembl:ENSG00000136160 | |
| GaQ | GeneProduct | ensembl:ENSG00000060558 | |
| GbQ | GeneProduct | ensembl:ENSG00000069966 | |
| GgQ | GeneProduct | ensembl:ENSG00000127588 | |
| PLCb | GeneProduct | ensembl:ENSG00000182621 | |
| PKC | GeneProduct | ensembl:ENSG00000154229 | |
| GaS | GeneProduct | ensembl:ENSG00000087460 | |
| GbS | GeneProduct | ensembl:ENSG00000069966 | |
| GgS | GeneProduct | ensembl:ENSG00000127588 | |
| GaQ | GeneProduct | ensembl:ENSG00000060558 | |
| GbQ | GeneProduct | ensembl:ENSG00000069966 | |
| GgQ | GeneProduct | ensembl:ENSG00000127588 | |
| b adrenergic receptor | GeneProduct | ensembl:ENSG00000043591 | |
| GaS | GeneProduct | ensembl:ENSG00000087460 | |
| GbS | GeneProduct | ensembl:ENSG00000069966 | |
| GgS | GeneProduct | ensembl:ENSG00000127588 | |
| CGRP | GeneProduct | ensembl:ENSG00000110680 | |
| CGRP | GeneProduct | ensembl:ENSG00000110680 | |
| GaS | GeneProduct | ensembl:ENSG00000087460 | |
| GbS | GeneProduct | ensembl:ENSG00000069966 | |
| GgS | GeneProduct | ensembl:ENSG00000127588 | |
| NPY | GeneProduct | ensembl:ENSG00000122585 | |
| NPY | GeneProduct | ensembl:ENSG00000122585 | |
| GaI | GeneProduct | ensembl:ENSG00000127955 | |
| GbI | GeneProduct | ensembl:ENSG00000069966 | |
| GgI | GeneProduct | ensembl:ENSG00000127588 |