Endothelin pathways (WP2197)

Homo sapiens

Endothelin-1 is a bicyclic 21 amino acid peptide, produced primarily in the endothelium. It is a potent stimulus of long-lasting and persistent vasoconstriction. It also has a role as a stimulus of inflammation, oxidative stress and cellular proliferation. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2197 CPTAC Assay Portal]

Authors

Sabine Daemen , Mireille Sthijns , Egon Willighagen , Kristina Hanspers , Christine Chichester , Alex Pico , Martina Summer-Kutmon , Lauren J. Dupuis , and Eric Weitz

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Renal Genomics Pathways

Annotations

Disease Ontology

benign essential hypertension hypertension

Pathway Ontology

G protein mediated signaling pathway via Galphas family G protein mediated signaling pathway via Galphaq family endothelin signaling pathway Ras superfamily mediated signaling pathway G protein mediated signaling pathway via Galphai family calcium/calmodulin dependent signaling pathway

Cell Type Ontology

blood vessel endothelial cell smooth muscle cell

Participants

Label Type Compact URI Comment
GTP Metabolite hmdb:HMDB0001440
L-Arginine Metabolite hmdb:HMDB0000517
K+ Metabolite hmdb:HMDB0000586
cGMP Metabolite hmdb:HMDB0001314
NO Metabolite hmdb:HMDB0003378
ATP Metabolite hmdb:HMDB0001532
cAMP Metabolite hmdb:HMDB0000058
Citrulline Metabolite hmdb:HMDB0000904
Arachidonic acid Metabolite hmdb:HMDB0001043
PGI2 Metabolite wikidata:Q412050
IP3 Metabolite hmdb:HMDB0001059
DAG Metabolite hmdb:HMDB0007008
Ca2+ Metabolite hmdb:HMDB0000464
PIP2 Metabolite hmdb:HMDB0010032
RAMP1 GeneProduct ensembl:ENSG00000132329
Y1 GeneProduct ensembl:ENSG00000164128
CGRP GeneProduct ensembl:ENSG00000110680
sGC GeneProduct ensembl:ENSG00000123201
SERCA GeneProduct ensembl:ENSG00000174437
PKA GeneProduct ensembl:ENSG00000178796
AC GeneProduct ensembl:ENSG00000143199 adenylate cyclase
COX2 GeneProduct ncbigene:4513
a adrenergic receptor GeneProduct ensembl:ENSG00000120907
NPY GeneProduct ensembl:ENSG00000122585
CRLR GeneProduct ensembl:ENSG00000064989
IP1 GeneProduct ensembl:ENSG00000160013 Prostaglandin I2 Receptor
eNOS GeneProduct ensembl:ENSG00000164867
Endothelin 1 GeneProduct ensembl:ENSG00000078401
ECE GeneProduct ensembl:ENSG00000117298
Cap GeneProduct ensembl:ENSG00000130176 Calponin; tonically inhibits the ATPase activity of myosin in smooth muscle
PKC GeneProduct ensembl:ENSG00000154229
GaQ GeneProduct ensembl:ENSG00000060558
MLC GeneProduct ensembl:ENSG00000168530 myosine light chain
MEK GeneProduct ensembl:ENSG00000169032
EDNRA GeneProduct ensembl:ENSG00000151617
MLCK GeneProduct ensembl:ENSG00000065534
ERK1/2 GeneProduct ensembl:ENSG00000100030
EDNRB GeneProduct ensembl:ENSG00000136160
RAF GeneProduct ensembl:ENSG00000132155
PLCb GeneProduct ensembl:ENSG00000182621
CAD GeneProduct ensembl:ENSG00000084774 Calmodulin binding protein; tonically inhibits the ATPase activity of myosin in smoothe muscle; mediating factor for Ca2+ dependent inhibition of smooth muscle contraction
CaM GeneProduct ensembl:ENSG00000198668
GbQ GeneProduct ensembl:ENSG00000069966
GgQ GeneProduct ensembl:ENSG00000127588
GaS GeneProduct ensembl:ENSG00000087460
GbS GeneProduct ensembl:ENSG00000069966
GgS GeneProduct ensembl:ENSG00000127588
b adrenergic receptor GeneProduct ensembl:ENSG00000043591
GaI GeneProduct ensembl:ENSG00000127955
GbI GeneProduct ensembl:ENSG00000069966
GgI GeneProduct ensembl:ENSG00000127588

References