Liver steatosis adverse outcome pathway (WP4010)

Homo sapiens

This liver steatosis AOP starts from the top with different molecular initiating events going down towards liver steatosis. The black nodes are Key Events and green nodes are molecular pathways. Adverse outcome pathway liver steatosis; the accumulation of lipids in hepatocytes, caused either by over-nutrition, visceral obesity, metabolic syndrome, or environmental toxins. Liver steatosis can be divided into three main categories: alcoholic liver disease (ALD), non-alcoholic liver disease (NAFLD), and toxicant-associated liver disease (TAFLD).[ Review on liver steatosis]


JJv Heijden , Alex Pico , Marvin Martens , Jeroen Kearns , Chesley De Windt , Eric Weitz , Finterly Hu , MysticArchers , and Martina Summer-Kutmon


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Homo sapiens


Adverse Outcome Pathways


Disease Ontology

fatty liver disease

Pathway Ontology

disease pathway

Cell Type Ontology



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