Estrogen receptor pathway (WP3163)
Bos taurus
The estrogen receptor is a nuclear receptor that is activated upon ligand binding and subsequently translocates to the nuclear. There, it activates transcription of target genes involved in essential cellular processes. The ER receptor has been implicated in a multitude of diseases, most notably cancer (breast/ovarian)
Authors
Martina Summer-Kutmon and Eric WeitzActivity
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Organisms
Bos taurusCommunities
Annotations
| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Ligand | Metabolite | chebi:48705 | |
| Ligand | Metabolite | chebi:48705 | |
| Ligand | Metabolite | chebi:48705 | |
| Ligand | Metabolite | chebi:48705 | |
| Ligand | Metabolite | chebi:48705 | |
| SP1 | GeneProduct | ensembl:ENSBTAG00000003021 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000185591 |
| ESR1 | GeneProduct | ensembl:ENSBTAG00000007159 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000091831 |
| JUN | GeneProduct | ensembl:ENSBTAG00000004037 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000177606 |
| ESR1 | GeneProduct | ensembl:ENSBTAG00000007159 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000091831 |
| ESR1 | GeneProduct | ensembl:ENSBTAG00000007159 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000091831 |
| ESR1 | GeneProduct | ensembl:ENSBTAG00000007159 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000091831 |
| ESR1 | GeneProduct | ensembl:ENSBTAG00000007159 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000091831 |
| ESR1 | GeneProduct | ensembl:ENSBTAG00000007159 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000091831 |
| ESR1 | GeneProduct | ensembl:ENSBTAG00000007159 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000091831 |
| ESR1 | GeneProduct | ensembl:ENSBTAG00000007159 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000091831 |
| PDK4 | GeneProduct | ensembl:ENSBTAG00000014069 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000004799 |
| STAT3 | GeneProduct | ensembl:ENSBTAG00000021523 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168610 |
| ACOX1 | GeneProduct | ensembl:ENSBTAG00000030174 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000161533 |
| GPAM | GeneProduct | ensembl:ENSBTAG00000011917 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000119927 |
| PCK1 | GeneProduct | ensembl:ENSBTAG00000001936 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000124253 |
| CYP1A1 | GeneProduct | ensembl:ENSBTAG00000001021 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140465 |
| PPARA | GeneProduct | ensembl:ENSBTAG00000008063 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186951 |
| CYP1A2 | GeneProduct | ensembl:ENSBTAG00000000085 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140505 |
| NR0B2 | GeneProduct | ensembl:ENSBTAG00000014848 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131910 |
| CYP1B1 | GeneProduct | ensembl:ENSBTAG00000010531 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138061 |
References
- Estrogen receptors: therapies targeted to receptor subtypes. Nilsson S, Gustafsson JÅ. Clin Pharmacol Ther. 2011 Jan;89(1):44–55. PubMed Europe PMC Scholia
- Pathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants. Fijten RRR, Jennen DGJ, van Delft JHM. Curr Drug Metab. 2013 Dec;14(10):1022–8. PubMed Europe PMC Scholia