Tryptophan metabolism (WP79)
Mus musculus
This pathway describes the metabolism of tryptophan, an essential amino acid. Originally converted from rat to human using ortholog information. Edited by Sebastien Burel
For a description of pathway objects, see the WikiPathways Legend.
Authors
Lynn M. Ferrante , Kristina Hanspers , Egon Willighagen , Daniela Digles , Alex Pico , Friederike Ehrhart , and Eric WeitzActivity
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Cited In
- Bioenergetic defects in muscle fibers of RYR1 mutant knock-in mice associated with malignant hyperthermia (2020).
- Hepatic transcriptome implications for palm fruit juice deterrence of type 2 diabetes mellitus in young male Nile rats (2016).
- Proteomic profiling of salivary gland after nonviral gene transfer mediated by conventional plasmids and minicircles (2014).
- Podocyte-specific KLF6 primes proximal tubule CaMK1D signaling to attenuate diabetic kidney disease (2024).
- A provisional gene regulatory atlas for mouse heart development (2014).
- Mammary tissue microbiome analysis in PyMT mice reveals Methylobacteria as a commensal organism with potential therapeutic applications (2025).
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Organisms
Mus musculusCommunities
Annotations
Pathway Ontology
tryptophan metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| 4-(2-Aminophenyl)-2,4-dioxobutanoate | Metabolite | chebi:58147 | 4-(2-Aminophenyl)-2,4-dioxobutanoate |
| Indolelactate | Metabolite | pubchem.compound:92904 | Indolelactate |
| 2-Aminomuconate | Metabolite | chemspider:27 | 2-Aminomuconate |
| 3-Methylindolepyruvate | Metabolite | pubchem.compound:440740 | 3-Methylindolepyruvate |
| 7,8-Dihydro-7,8-dihydroxykynurenate | Metabolite | chemspider:388563 | 7,8-Dihydro-7,8-dihydroxykynurenate |
| Indole-3-acetate | Metabolite | chemspider:780 | Indole-3-acetate |
| N-Methylserotonin | Metabolite | pubchem.compound:150885 | N-Methylserotonin |
| C00877 | Metabolite | kegg.compound:C00877 | Crotonoyl-CoA |
| N-Methyltryptamine | Metabolite | chebi:28136 | N-Methyltryptamine |
| 4,8-Dihydroxyquinoline | Metabolite | chebi:28883 | 4,8-Dihydroxyquinoline |
| 4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate | Metabolite | chemspider:389617 | 4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate |
| Oxaloacetate | Metabolite | chebi:16452 | Oxaloacetate |
| 3-(2-Aminoethyl)-1H-indol-5-ol | Metabolite | pubchem.compound:5202 | 3-(2-Aminoethyl)-1H-indol-5-ol |
| Indolepyruvate | Metabolite | pubchem.compound:803 | Indolepyruvate |
| Melatonin | Metabolite | pubchem.compound:896 | |
| Indole-3-acetaldehyde | Metabolite | chebi:18086 | Indole-3-acetaldehyde |
| Glucobrassicin | Metabolite | chebi:29028 | Glucobrassicin |
| Kynurenate | Metabolite | chebi:18344 | 4-Hydroxy-2-quinolinecarboxylic |
| C00527 | Metabolite | kegg.compound:C00527 | Glutaryl-CoA |
| Formylanthranilate | Metabolite | chebi:18410 | Formylanthranilate |
| 3-Hydroxy-L-kynurenine | Metabolite | chebi:17380 | 3-Hydroxy-L-kynurenine |
| 5-Methoxyindoleacetate | Metabolite | pubchem.compound:18986 | 5-Methoxyindoleacetate |
| 3-Methyldioxyindole | Metabolite | chebi:28254 | |
| C01144 | Metabolite | kegg.compound:C01144 | (S)-3-Hydroxybutanoyl-CoA |
| 5-Hydroxyindoleacetaldehyde | Metabolite | pubchem.compound:74688 | 5-Hydroxyindoleacetaldehyde |
| 3-Hydroxyanthranilate | Metabolite | chemspider:7822291 | 3-Hydroxyanthranilate |
| Indole-3-acetaldoxime | Metabolite | chebi:28311 | Indole-3-acetaldoxime |
| 5-Hydroxy-N-formylkynurenine | Metabolite | chemspider:389615 | 5-Hydroxy-N-formylkynurenine |
| Isophenoxazine | Metabolite | chemspider:65565 | Isophenoxazine |
| 5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate | Metabolite | chemspider:389619 | 5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate |
| Indole-3-ethanol | Metabolite | pubchem.compound:10685 | |
| 6-Hydroxyindolelactate | Metabolite | chebi:27524 | 6-Hydroxyindolelactate |
| Anthranilate | Metabolite | chebi:16567 | Anthranilate |
| 5-Hydroxykynurenamine | Metabolite | chemspider:144400 | 5-Hydroxykynurenamine |
| 2-Formylaminobenzaldehyde | Metabolite | chebi:18033 | |
| 4,6-Dihydroxyquinoline | Metabolite | chemspider:389609 | 4,6-Dihydroxyquinoline |
| 2,3-Dihydroxyindole | Metabolite | chebi:17828 | |
| Quinolinate | Metabolite | chemspider:2777129 | |
| Cinnavalininate | Metabolite | chemspider:102864 | Cinnavalininate |
| 5-Hydroxy-L-tryptophan | Metabolite | chebi:17780 | 5-Hydroxy-L-tryptophan |
| 3-Hydroxykynurenamine | Metabolite | chemspider:144400 | 3-Hydroxykynurenamine |
| Formyl-5-hydroxykynurenamine | Metabolite | pubchem.compound:440743 | |
| 5-Hydroxyindolepyruvate | Metabolite | chemspider:389613 | |
| 3-Methoxyanthranilate | Metabolite | chebi:20109 | 3-Methoxyanthranilate |
| 2-Oxoglutarate | Metabolite | chebi:30916 | 2-Oxoglutarate |
| N-Acetylindoxyl | Metabolite | chebi:15363 | N-Acetylindoxyl |
| 2-Oxoadipate | Metabolite | chemspider:70 | 2-Oxoadipate |
| 7,8-Dihydroxykynurenate | Metabolite | chebi:58171 | 7,8-Dihydroxykynurenate |
| Xanthurenic | Metabolite | chemspider:5497 | Xanthurenic |
| 5-Hydroxyindoleacetate | Metabolite | pubchem.compound:1826 | 5-Hydroxyindoleacetate |
| C00332 | Metabolite | kegg.compound:C00332 | Acetoacetyl-CoA |
| 5-(3'-Carboxy-3'-oxopropyl) -4,6-dihydroxypicolinate | Metabolite | chemspider:389620 | 5-(3'-Carboxy-3'-oxopropyl)-4,6-dihydroxypicolinate |
| (Z)-5-Oxohex-2-enedioate | Metabolite | chebi:16967 | (Z)-5-Oxohex-2-enedioate |
| 5-(2'-Formylethyl)-4,6-dihydroxypicolinate | Metabolite | chemspider:389618 | 5-(2'-Formylethyl)-4,6-dihydroxypicolinate |
| Formyl-N-acetyl-5-methoxykynurenamine | Metabolite | pubchem.compound:171161 | Formyl-N-acetyl-5-methoxykynurenamine |
| 3-Indoleglycolaldehyde | Metabolite | chebi:15976 | |
| 8-Methoxykynurenate | Metabolite | chebi:20109 | 8-Methoxykynurenate |
| 6-Hydroxykynurenate | Metabolite | chemspider:389622 | 6-Hydroxykynurenate |
| 5-Hydroxyindoleacetylglycine | Metabolite | pubchem.compound:440806 | |
| Formylkynurenine | Metabolite | chebi:30249 | Formylkynurenine |
| Acetyl-CoA | Metabolite | chebi:15351 | Acetyl-CoA |
| Indole | Metabolite | pubchem.compound:798 | |
| 5-Methoxytryptamine | Metabolite | chebi:2089 | |
| L-Kynurenine | Metabolite | chebi:16946 | L-Kynurenine |
| 5-Hydroxykynurenine | Metabolite | chemspider:389616 | |
| Tryptamine | Metabolite | chebi:16765 | |
| N-Acetylisatin | Metabolite | chebi:16050 | N-Acetylisatin |
| L-Tryptophan | Metabolite | pubchem.compound:6305 | |
| Indole-3-acetamide | Metabolite | chebi:16031 | Indole-3-acetamide |
| 3-Indoleacetonitrile | Metabolite | chebi:17566 | 3-Indoleacetonitrile |
| 2-Aminophenol | Metabolite | chebi:18112 | 2-Aminophenol |
| 6-Hydroxymelatonin | Metabolite | pubchem.compound:1864 | |
| N-Acetylserotonin | Metabolite | chebi:17697 | N-Acetylserotonin |
| Cyp4f14 | GeneProduct | ncbigene:64385 | |
| Ubr5 | GeneProduct | ncbigene:70790 | |
| Ido1 | GeneProduct | ncbigene:15930 | |
| Cyp2e1 | GeneProduct | ncbigene:13106 | |
| Rnf25 | GeneProduct | ncbigene:57751 | |
| Gcdh | GeneProduct | ncbigene:270076 | predicted |
| Aldh9a1 | GeneProduct | ncbigene:56752 | |
| Prmt1 | GeneProduct | ncbigene:15469 | |
| Aldh2 | GeneProduct | ncbigene:11669 | |
| Aldh1a2 | GeneProduct | ncbigene:19378 | |
| ASMT | GeneProduct | ncbigene:107626 | |
| Cyp1a1 | GeneProduct | ncbigene:13076 | |
| Mdm2 | GeneProduct | ncbigene:17246 | |
| Ogdh | GeneProduct | ncbigene:18293 | |
| Maob | GeneProduct | ncbigene:109731 | |
| Aldh3a2 | GeneProduct | ncbigene:11671 | |
| Ddc | GeneProduct | ncbigene:13195 | |
| Hsd17b10 | GeneProduct | ncbigene:15108 | |
| Cat | GeneProduct | ncbigene:12359 | |
| Ube3a | GeneProduct | ncbigene:22215 | |
| Hadh | GeneProduct | ncbigene:15107 | |
| Cyp7b1 | GeneProduct | ncbigene:13123 | |
| Aadat | GeneProduct | ncbigene:23923 | |
| Acat1 | GeneProduct | ncbigene:110446 | |
| Kynu | GeneProduct | ncbigene:70789 | |
| Afmid | GeneProduct | ncbigene:71562 | |
| Cyp1b1 | GeneProduct | ncbigene:13078 | |
| Aanat | GeneProduct | ncbigene:11298 | |
| Aox1 | GeneProduct | ncbigene:11761 | |
| Dhcr24 | GeneProduct | ncbigene:74754 | predicted |
| Acmsd | GeneProduct | ncbigene:266645 | |
| Cyp1a2 | GeneProduct | ncbigene:13077 | |
| Cyp2c55 | GeneProduct | ncbigene:72082 | |
| Wars | GeneProduct | ncbigene:22375 | |
| Inmt | GeneProduct | ncbigene:21743 | |
| Cyp19a1 | GeneProduct | ncbigene:13075 | |
| Aldh1a1 | GeneProduct | ncbigene:11668 | |
| Cyp2j6 | GeneProduct | ncbigene:13110 | |
| Haao | GeneProduct | ncbigene:107766 | |
| Abp1 | GeneProduct | ncbigene:76507 | |
| Echs1 | GeneProduct | ncbigene:93747 | |
| Tdo2 | GeneProduct | ncbigene:56720 | |
| Cyp2f2 | GeneProduct | ncbigene:13107 | |
| Tph1 | GeneProduct | ncbigene:21990 |