Tryptophan metabolism (WP79)

Mus musculus

This pathway describes the metabolism of tryptophan, an essential amino acid. Originally converted from rat to human using ortholog information. Edited by Sebastien Burel

Authors

Lynn M. Ferrante , Kristina Hanspers , Egon Willighagen , Daniela Digles , Alex Pico , Friederike Ehrhart , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

tryptophan metabolic pathway

Participants

Label Type Compact URI Comment
4-(2-Aminophenyl)-2,4-dioxobutanoate Metabolite chebi:58147 4-(2-Aminophenyl)-2,4-dioxobutanoate
Indolelactate Metabolite pubchem.compound:92904 Indolelactate
2-Aminomuconate Metabolite chemspider:27 2-Aminomuconate
3-Methylindolepyruvate Metabolite pubchem.compound:440740 3-Methylindolepyruvate
7,8-Dihydro-7,8-dihydroxykynurenate Metabolite chemspider:388563 7,8-Dihydro-7,8-dihydroxykynurenate
Indole-3-acetate Metabolite chemspider:780 Indole-3-acetate
N-Methylserotonin Metabolite pubchem.compound:150885 N-Methylserotonin
C00877 Metabolite kegg.compound:C00877 Crotonoyl-CoA
N-Methyltryptamine Metabolite chebi:28136 N-Methyltryptamine
4,8-Dihydroxyquinoline Metabolite chebi:28883 4,8-Dihydroxyquinoline
4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate Metabolite chemspider:389617 4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate
Oxaloacetate Metabolite chebi:16452 Oxaloacetate
3-(2-Aminoethyl)-1H-indol-5-ol Metabolite pubchem.compound:5202 3-(2-Aminoethyl)-1H-indol-5-ol
Indolepyruvate Metabolite pubchem.compound:803 Indolepyruvate
Melatonin Metabolite pubchem.compound:896
Indole-3-acetaldehyde Metabolite chebi:18086 Indole-3-acetaldehyde
Glucobrassicin Metabolite chebi:29028 Glucobrassicin
Kynurenate Metabolite chebi:18344 4-Hydroxy-2-quinolinecarboxylic
C00527 Metabolite kegg.compound:C00527 Glutaryl-CoA
Formylanthranilate Metabolite chebi:18410 Formylanthranilate
3-Hydroxy-L-kynurenine Metabolite chebi:17380 3-Hydroxy-L-kynurenine
5-Methoxyindoleacetate Metabolite pubchem.compound:18986 5-Methoxyindoleacetate
3-Methyldioxyindole Metabolite chebi:28254
C01144 Metabolite kegg.compound:C01144 (S)-3-Hydroxybutanoyl-CoA
5-Hydroxyindoleacetaldehyde Metabolite pubchem.compound:74688 5-Hydroxyindoleacetaldehyde
3-Hydroxyanthranilate Metabolite chemspider:7822291 3-Hydroxyanthranilate
Indole-3-acetaldoxime Metabolite chebi:28311 Indole-3-acetaldoxime
5-Hydroxy-N-formylkynurenine Metabolite chemspider:389615 5-Hydroxy-N-formylkynurenine
Isophenoxazine Metabolite chemspider:65565 Isophenoxazine
5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate Metabolite chemspider:389619 5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate
Indole-3-ethanol Metabolite pubchem.compound:10685
6-Hydroxyindolelactate Metabolite chebi:27524 6-Hydroxyindolelactate
Anthranilate Metabolite chebi:16567 Anthranilate
5-Hydroxykynurenamine Metabolite chemspider:144400 5-Hydroxykynurenamine
2-Formylaminobenzaldehyde Metabolite chebi:18033
4,6-Dihydroxyquinoline Metabolite chemspider:389609 4,6-Dihydroxyquinoline
2,3-Dihydroxyindole Metabolite chebi:17828
Quinolinate Metabolite chemspider:2777129
Cinnavalininate Metabolite chemspider:102864 Cinnavalininate
5-Hydroxy-L-tryptophan Metabolite chebi:17780 5-Hydroxy-L-tryptophan
3-Hydroxykynurenamine Metabolite chemspider:144400 3-Hydroxykynurenamine
Formyl-5-hydroxykynurenamine Metabolite pubchem.compound:440743
5-Hydroxyindolepyruvate Metabolite chemspider:389613
3-Methoxyanthranilate Metabolite chebi:20109 3-Methoxyanthranilate
2-Oxoglutarate Metabolite chebi:30916 2-Oxoglutarate
N-Acetylindoxyl Metabolite chebi:15363 N-Acetylindoxyl
2-Oxoadipate Metabolite chemspider:70 2-Oxoadipate
7,8-Dihydroxykynurenate Metabolite chebi:58171 7,8-Dihydroxykynurenate
Xanthurenic Metabolite chemspider:5497 Xanthurenic
5-Hydroxyindoleacetate Metabolite pubchem.compound:1826 5-Hydroxyindoleacetate
C00332 Metabolite kegg.compound:C00332 Acetoacetyl-CoA
5-(3'-Carboxy-3'-oxopropyl) -4,6-dihydroxypicolinate Metabolite chemspider:389620 5-(3'-Carboxy-3'-oxopropyl)-4,6-dihydroxypicolinate
(Z)-5-Oxohex-2-enedioate Metabolite chebi:16967 (Z)-5-Oxohex-2-enedioate
5-(2'-Formylethyl)-4,6-dihydroxypicolinate Metabolite chemspider:389618 5-(2'-Formylethyl)-4,6-dihydroxypicolinate
Formyl-N-acetyl-5-methoxykynurenamine Metabolite pubchem.compound:171161 Formyl-N-acetyl-5-methoxykynurenamine
3-Indoleglycolaldehyde Metabolite chebi:15976
8-Methoxykynurenate Metabolite chebi:20109 8-Methoxykynurenate
6-Hydroxykynurenate Metabolite chemspider:389622 6-Hydroxykynurenate
5-Hydroxyindoleacetylglycine Metabolite pubchem.compound:440806
Formylkynurenine Metabolite chebi:30249 Formylkynurenine
Acetyl-CoA Metabolite chebi:15351 Acetyl-CoA
Indole Metabolite pubchem.compound:798
5-Methoxytryptamine Metabolite chebi:2089
L-Kynurenine Metabolite chebi:16946 L-Kynurenine
5-Hydroxykynurenine Metabolite chemspider:389616
Tryptamine Metabolite chebi:16765
N-Acetylisatin Metabolite chebi:16050 N-Acetylisatin
L-Tryptophan Metabolite pubchem.compound:6305
Indole-3-acetamide Metabolite chebi:16031 Indole-3-acetamide
3-Indoleacetonitrile Metabolite chebi:17566 3-Indoleacetonitrile
2-Aminophenol Metabolite chebi:18112 2-Aminophenol
6-Hydroxymelatonin Metabolite pubchem.compound:1864
N-Acetylserotonin Metabolite chebi:17697 N-Acetylserotonin
Cyp4f14 GeneProduct ncbigene:64385
Ubr5 GeneProduct ncbigene:70790
Ido1 GeneProduct ncbigene:15930
Cyp2e1 GeneProduct ncbigene:13106
Rnf25 GeneProduct ncbigene:57751
Gcdh GeneProduct ncbigene:270076 predicted
Aldh9a1 GeneProduct ncbigene:56752
Prmt1 GeneProduct ncbigene:15469
Aldh2 GeneProduct ncbigene:11669
Aldh1a2 GeneProduct ncbigene:19378
ASMT GeneProduct ncbigene:107626
Cyp1a1 GeneProduct ncbigene:13076
Mdm2 GeneProduct ncbigene:17246
Ogdh GeneProduct ncbigene:18293
Maob GeneProduct ncbigene:109731
Aldh3a2 GeneProduct ncbigene:11671
Ddc GeneProduct ncbigene:13195
Hsd17b10 GeneProduct ncbigene:15108
Cat GeneProduct ncbigene:12359
Ube3a GeneProduct ncbigene:22215
Hadh GeneProduct ncbigene:15107
Cyp7b1 GeneProduct ncbigene:13123
Aadat GeneProduct ncbigene:23923
Acat1 GeneProduct ncbigene:110446
Kynu GeneProduct ncbigene:70789
Afmid GeneProduct ncbigene:71562
Cyp1b1 GeneProduct ncbigene:13078
Aanat GeneProduct ncbigene:11298
Aox1 GeneProduct ncbigene:11761
Dhcr24 GeneProduct ncbigene:74754 predicted
Acmsd GeneProduct ncbigene:266645
Cyp1a2 GeneProduct ncbigene:13077
Cyp2c55 GeneProduct ncbigene:72082
Wars GeneProduct ncbigene:22375
Inmt GeneProduct ncbigene:21743
Cyp19a1 GeneProduct ncbigene:13075
Aldh1a1 GeneProduct ncbigene:11668
Cyp2j6 GeneProduct ncbigene:13110
Haao GeneProduct ncbigene:107766
Abp1 GeneProduct ncbigene:76507
Echs1 GeneProduct ncbigene:93747
Tdo2 GeneProduct ncbigene:56720
Cyp2f2 GeneProduct ncbigene:13107
Tph1 GeneProduct ncbigene:21990

References