N-glycan biosynthesis (WP5153)

Homo sapiens

Open in new tab
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
This pathways describes the biosynthesis of N-linked (Asparagine-linked) glycans, to form glycoproteins. This process is a type of co-translational and post-translational modification and sometimes referred to as N-linked glycosylation. Glycosylation is important for many processes, including protein folding and cell-cell adhesion and immune function. This pathway was modeled based on Figure 9.3 and 9.4 from [https://www.ncbi.nlm.nih.gov/books/NBK453020/ Essentials of Glycobiology [Internet]. 3rd edition], Figure 17.1 from [https://link.springer.com/chapter/10.1007/978-981-13-2835-0_17 Dall'Olio] and [https://www.genome.jp/pathway/hsa00510 KEGG].

Authors

Kristina Hanspers and Egon Willighagen

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

N-linked glycan biosynthetic pathway protein modification pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Dolichol Metabolite chebi:88766
G10595 Metabolite kegg.glycan:G10595
Polyprenol Metabolite chebi:26199
dolichyl diphosphate Metabolite hmdb:HMDB01513
Dolichyl phosphate D-mannose Metabolite hmdb:HMDB00994
Fructose-6-phosphate Metabolite hmdb:HMDB0000124
GDP-D-mannose Metabolite chebi:84880
G00171 Metabolite kegg.glycan:G00171
G00010 Metabolite kegg.glycan:G00010
G00011 Metabolite kegg.glycan:G00011
G10694 Metabolite kegg.glycan:G10694
G00012 Metabolite kegg.glycan:G00012
G00013 Metabolite kegg.glycan:G00013
G00014 Metabolite kegg.glycan:G00014
G00015 Metabolite kegg.glycan:G00015
G00019 Metabolite kegg.glycan:G00019
G00020 Metabolite kegg.glycan:G00020
G00016 Metabolite kegg.glycan:G00016
G00021 Metabolite kegg.glycan:G00021
G00022 Metabolite kegg.glycan:G00022
G00017 Metabolite kegg.glycan:G00017
G00018 Metabolite kegg.glycan:G00018
G10596 Metabolite kegg.glycan:G10596
G10597 Metabolite kegg.glycan:G10597
G00007 Metabolite kegg.glycan:G00007
G10598 Metabolite kegg.glycan:G10598
G10599 Metabolite kegg.glycan:G10599
G00008 Metabolite kegg.glycan:G00008
G00006 Metabolite kegg.glycan:G00006
G00009 Metabolite kegg.glycan:G00009
dolichyl phosphate Metabolite chebi:16214
G00001 Metabolite kegg.glycan:G00001
G00002 Metabolite kegg.glycan:G00002
G00003 Metabolite kegg.glycan:G00003
G00004 Metabolite kegg.glycan:G00004
G00005 Metabolite kegg.glycan:G00005
G10526 Metabolite kegg.glycan:G10526
G00006 Metabolite kegg.glycan:G00006
dolichyl β-D-glucosyl phosphate Metabolite chebi:15812
dolichyl phosphate Metabolite chebi:16214
dolichyl phosphate Metabolite chebi:16214
Glucose 6-phosphate Metabolite hmdb:HMDB0001401
Mannose-6-phosphate Metabolite hmdb:HMDB0001078
D-mannose 1-phosphate Metabolite chebi:35374
G10694 Metabolite kegg.glycan:G10694
MOGS GeneProduct ensembl:ENSG00000115275
MPDU1 GeneProduct ensembl:ENSG00000129255
DAD1 GeneProduct ensembl:ENSG00000129562
STT3B GeneProduct ensembl:ENSG00000163527
DOLPP1 GeneProduct ensembl:ENSG00000167130
RFT1 GeneProduct ensembl:ENSG00000163933
ALG10 GeneProduct ensembl:ENSG00000139133
GANAB GeneProduct ensembl:ENSG00000089597
MAN1B1 GeneProduct ensembl:ENSG00000177239
MGAT1 GeneProduct ensembl:ENSG00000131446
MAN1A1 GeneProduct ensembl:ENSG00000111885
MAN2A1 GeneProduct ensembl:ENSG00000112893
MAN1A2 GeneProduct ensembl:ENSG00000198162
MAN1C1 GeneProduct ensembl:ENSG00000117643
MAN2A2 GeneProduct ensembl:ENSG00000196547
MGAT2 GeneProduct ensembl:ENSG00000168282
MGAT3 GeneProduct ensembl:ENSG00000128268
FUT8 GeneProduct ensembl:ENSG00000033170
B4GALT1 GeneProduct ensembl:ENSG00000086062
B4GALT2 GeneProduct ensembl:ENSG00000117411
B4GALT3 GeneProduct ensembl:ENSG00000158850
ST6GAL1 GeneProduct ensembl:ENSG00000073849
ST6GAL2 GeneProduct ensembl:ENSG00000144057
MGAT5 GeneProduct ensembl:ENSG00000152127
MGAT4C GeneProduct ensembl:ENSG00000182050
ALG8 GeneProduct ensembl:ENSG00000159063
ALG6 GeneProduct ensembl:ENSG00000088035
ALG9 GeneProduct ensembl:ENSG00000086848
ALG12 GeneProduct ensembl:ENSG00000182858
ALG3 GeneProduct ensembl:ENSG00000214160
STT3A GeneProduct ensembl:ENSG00000134910
DDOST GeneProduct ensembl:ENSG00000244038
RPN1 GeneProduct ensembl:ENSG00000163902
RPN2 GeneProduct ensembl:ENSG00000118705
TUSC3 GeneProduct ensembl:ENSG00000104723
DOLK GeneProduct ensembl:ENSG00000175283
SRD5A3 GeneProduct ensembl:ENSG00000128039
DPAGT1 GeneProduct ensembl:ENSG00000172269
ALG13 GeneProduct ensembl:ENSG00000101901
ALG14 GeneProduct ensembl:ENSG00000172339
ALG1 GeneProduct ensembl:ENSG00000033011
ALG2 GeneProduct ensembl:ENSG00000119523
ALG11 GeneProduct ensembl:ENSG00000253710
DPM1 GeneProduct ensembl:ENSG00000000419
DPM2 GeneProduct ensembl:ENSG00000136908
DPM3 GeneProduct ensembl:ENSG00000179085
MPDU1 GeneProduct ensembl:ENSG00000129255
ALG5 GeneProduct ensembl:ENSG00000120697
GMPPA GeneProduct ensembl:ENSG00000144591
GMPPB GeneProduct ensembl:ENSG00000173540
PMM2 GeneProduct ensembl:ENSG00000140650
MPI GeneProduct ensembl:ENSG00000178802
GPI GeneProduct ensembl:ENSG00000105220
MGAT4B GeneProduct hgnc.symbol:MGAT4B
MGAT4A GeneProduct ncbigene:11320
MGAT4D GeneProduct ncbigene:152586
MGAT5B GeneProduct ncbigene:146664
ALG10B GeneProduct ensembl:ENSG00000175548

References

  1. KEGG Pathway: hsa00510
  2. A mutation in the human MPDU1 gene causes congenital disorder of glycosylation type If (CDG-If). Kranz C, Denecke J, Lehrman MA, Ray S, Kienz P, Kreissel G, et al. J Clin Invest. 2001 Dec;108(11):1613–9. PubMed Europe PMC Scholia
  3. N-Glycans. Stanley P, Taniguchi N, Aebi M. In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, et al., editors. Essentials of Glycobiology. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2017. p. 99–111. PubMed Europe PMC Scholia
  4. Glycobiology of Aging. Dall’Olio F. Subcell Biochem. 2018;90:505–26. PubMed Europe PMC Scholia