Neurogenesis regulation in the olfactory epithelium (WP5265)

Homo sapiens

Transcriptional regulatory network during neuronal and non-neuronal lineage in the olfactory epithelium.

Authors

, Alex Pico , and Egon Willighagen

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Disease Ontology

olfactory neuroblastoma

Pathway Ontology

regulatory pathway regulatory pathway pertinent to the brain Notch signaling pathway signaling pathway

Participants

Label Type Compact URI Comment
HES1 GeneProduct ensembl:ENSG00000114315
APP GeneProduct ensembl:ENSG00000142192
NEURL1 GeneProduct ensembl:ENSG00000107954
AGRN GeneProduct ensembl:ENSG00000188157
NOTCH1 GeneProduct ensembl:ENSG00000148400
ERBB4 GeneProduct ensembl:ENSG00000178568
SOX2 GeneProduct ensembl:ENSG00000181449
MECP2 GeneProduct ensembl:ENSG00000169057
MAP1B GeneProduct ensembl:ENSG00000131711
KDM1A GeneProduct ensembl:ENSG00000004487
NEUROD1 GeneProduct ensembl:ENSG00000162992
BDNF GeneProduct ensembl:ENSG00000176697
RET GeneProduct ensembl:ENSG00000165731
RET GeneProduct ensembl:ENSG00000165731
SEMA4A GeneProduct ensembl:ENSG00000196189
PAX6 GeneProduct ensembl:ENSG00000007372
MRE11A GeneProduct ensembl:ENSG00000020922
GHRL GeneProduct ensembl:ENSG00000157017
ID1 GeneProduct ensembl:ENSG00000125968
ID2 GeneProduct ensembl:ENSG00000115738
TCF3 GeneProduct ensembl:ENSG00000071564
TCF4 GeneProduct ensembl:ENSG00000196628
NEUROG3 GeneProduct ensembl:ENSG00000122859
MEF2C GeneProduct ensembl:ENSG00000081189
NTRK3 GeneProduct ensembl:ENSG00000140538
NTRK1 GeneProduct ensembl:ENSG00000198400
NTRK2 GeneProduct ensembl:ENSG00000148053
FAIM GeneProduct ensembl:ENSG00000158234
NGF GeneProduct ensembl:ENSG00000134259
PLXND1 GeneProduct ensembl:ENSG00000004399
CXCL12 GeneProduct ensembl:ENSG00000107562
NGFR GeneProduct ensembl:ENSG00000064300
PSEN1 GeneProduct ensembl:ENSG00000080815
APP GeneProduct ensembl:ENSG00000142192
DAB1 GeneProduct ensembl:ENSG00000173406
DISC1 GeneProduct ensembl:ENSG00000162946
MAP2 GeneProduct ensembl:ENSG00000078018
NUMBL GeneProduct ensembl:ENSG00000105245
LRP8 GeneProduct ensembl:ENSG00000157193
RELN GeneProduct ensembl:ENSG00000189056
VLDLR GeneProduct ensembl:ENSG00000147852
NDEL1 GeneProduct ensembl:ENSG00000166579
NUMB GeneProduct ensembl:ENSG00000133961
MARK2 GeneProduct ensembl:ENSG00000072518
MAPT GeneProduct ensembl:ENSG00000186868
PAFAH1B1 GeneProduct ensembl:ENSG00000007168
RTN4 GeneProduct ensembl:ENSG00000115310
RTN4R GeneProduct ensembl:ENSG00000040608
SOX2 GeneProduct ensembl:ENSG00000181449
STAT3 GeneProduct ensembl:ENSG00000168610
JAG1 GeneProduct ensembl:ENSG00000101384
DLL1 GeneProduct ensembl:ENSG00000198719
HEY1 GeneProduct ensembl:ENSG00000164683
GSK3B GeneProduct ensembl:ENSG00000082701
CDK5R1 GeneProduct ensembl:ENSG00000176749
CDK5 GeneProduct ensembl:ENSG00000164885
NRG1 GeneProduct ensembl:ENSG00000157168
NUMB GeneProduct ensembl:ENSG00000133961
ASCL1 GeneProduct ensembl:ENSG00000139352
MYC GeneProduct ensembl:ENSG00000136997
IL17A GeneProduct ensembl:ENSG00000112115

References

  1. Differential interactions of Id proteins with basic-helix-loop-helix transcription factors. Langlands K, Yin X, Anand G, Prochownik EV. J Biol Chem. 1997 Aug 8;272(32):19785–93. PubMed Europe PMC Scholia
  2. Predominant localization of the LIS family of gene products to Cajal-Retzius cells and ventricular neuroepithelium in the developing human cortex. Clark GD, Mizuguchi M, Antalffy B, Barnes J, Armstrong D. J Neuropathol Exp Neurol. 1997 Sep;56(9):1044–52. PubMed Europe PMC Scholia
  3. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P, Tsai LH. Nature. 1999 Dec 9;402(6762):615–22. PubMed Europe PMC Scholia
  4. The regulation of presenilin-1 by nerve growth factor. Counts SE, Lah JJ, Levey AI. J Neurochem. 2001 Feb;76(3):679–89. PubMed Europe PMC Scholia
  5. A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system. Sasaki S, Shionoya A, Ishida M, Gambello MJ, Yingling J, Wynshaw-Boris A, et al. Neuron. 2000 Dec;28(3):681–96. PubMed Europe PMC Scholia
  6. 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome. Toyo-oka K, Shionoya A, Gambello MJ, Cardoso C, Leventer R, Ward HL, et al. Nat Genet. 2003 Jul;34(3):274–85. PubMed Europe PMC Scholia
  7. Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Chen WG, Chang Q, Lin Y, Meissner A, West AE, Griffith EC, et al. Science. 2003 Oct 31;302(5646):885–9. PubMed Europe PMC Scholia
  8. The death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-kapp B signaling. Sole C, Dolcet X, Segura MF, Gutierrez H, Diaz-Meco MT, Gozzelino R, et al. J Cell Biol. 2004 Nov 8;167(3):479–92. PubMed Europe PMC Scholia
  9. DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1. Taya S, Shinoda T, Tsuboi D, Asaki J, Nagai K, Hikita T, et al. J Neurosci. 2007 Jan 3;27(1):15–26. PubMed Europe PMC Scholia
  10. The Pafah1b complex interacts with the reelin receptor VLDLR. Zhang G, Assadi AH, McNeil RS, Beffert U, Wynshaw-Boris A, Herz J, et al. PLoS One. 2007 Feb 28;2(2):e252. PubMed Europe PMC Scholia
  11. The E-protein Tcf4 interacts with Math1 to regulate differentiation of a specific subset of neuronal progenitors. Flora A, Garcia JJ, Thaller C, Zoghbi HY. Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15382–7. PubMed Europe PMC Scholia
  12. Polarity-regulating kinase partitioning-defective 1/microtubule affinity-regulating kinase 2 negatively regulates development of dendrites on hippocampal neurons. Terabayashi T, Itoh TJ, Yamaguchi H, Yoshimura Y, Funato Y, Ohno S, et al. J Neurosci. 2007 Nov 28;27(48):13098–107. PubMed Europe PMC Scholia
  13. Association between Presenilin-1 and TRAF6 modulates regulated intramembrane proteolysis of the p75NTR neurotrophin receptor. Powell JC, Twomey C, Jain R, McCarthy JV. J Neurochem. 2009 Jan;108(1):216–30. PubMed Europe PMC Scholia
  14. Involvement of Dab1 in APP processing and beta-amyloid deposition in sporadic Creutzfeldt-Jakob patients. Gavín R, Ferrer I, del Río JA. Neurobiol Dis. 2010 Feb;37(2):324–9. PubMed Europe PMC Scholia
  15. Presenilin-1 processing of ErbB4 in fetal type II cells is necessary for control of fetal lung maturation. Hoeing K, Zscheppang K, Mujahid S, Murray S, Volpe MV, Dammann CEL, et al. Biochim Biophys Acta. 2011 Mar;1813(3):480–91. PubMed Europe PMC Scholia
  16. A Cdk5-dependent switch regulates Lis1/Ndel1/dynein-driven organelle transport in adult axons. Pandey JP, Smith DS. J Neurosci. 2011 Nov 23;31(47):17207–19. PubMed Europe PMC Scholia
  17. Reelin together with ApoER2 regulates interneuron migration in the olfactory bulb. Hellwig S, Hack I, Zucker B, Brunne B, Junghans D. PLoS One. 2012;7(11):e50646. PubMed Europe PMC Scholia
  18. Contributions of VLDLR and LRP8 in the establishment of retinogeniculate projections. Su J, Klemm MA, Josephson AM, Fox MA. Neural Dev. 2013 Jun 13;8:11. PubMed Europe PMC Scholia
  19. KIF5B-RET fusion kinase promotes cell growth by multilevel activation of STAT3 in lung cancer. Qian Y, Chai S, Liang Z, Wang Y, Zhou Y, Xu X, et al. Mol Cancer. 2014 Jul 21;13:176. PubMed Europe PMC Scholia
  20. Intramuscular delivery of p75NTR ectodomain by an AAV vector attenuates cognitive deficits and Alzheimer’s disease-like pathologies in APP/PS1 transgenic mice. Wang QH, Wang YR, Zhang T, Jiao SS, Liu YH, Zeng F, et al. J Neurochem. 2016 Jul;138(1):163–73. PubMed Europe PMC Scholia
  21. Roles of p75NTR in Maintaining Brain Hemostasis and the Implications for p75NTR-targeted Therapies. Gao C, Zhang L, Sun D, Li J, Yao X, Zhou H, et al. Curr Alzheimer Res. 2017;14(5):554–61. PubMed Europe PMC Scholia
  22. How does Reelin signaling regulate the neuronal cytoskeleton during migration? Chai X, Frotscher M. Neurogenesis (Austin). 2016 Sep 29;3(1):e1242455. PubMed Europe PMC Scholia
  23. Functional Roles of the Interaction of APP and Lipoprotein Receptors. Pohlkamp T, Wasser CR, Herz J. Front Mol Neurosci. 2017 Mar 1;10:54. PubMed Europe PMC Scholia
  24. DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis. Ye F, Kang E, Yu C, Qian X, Jacob F, Yu C, et al. Neuron. 2017 Dec 6;96(5):1041-1054.e5. PubMed Europe PMC Scholia
  25. Integrative computational evaluation of genetic markers for Alzheimer’s disease. Li Z, Xiong Z, Manor LC, Cao H, Li T. Saudi J Biol Sci. 2018 Jul;25(5):996–1002. PubMed Europe PMC Scholia
  26. Dynamic expression of p75NTR and Lingo-1 during development of mouse retinofugal pathway. Wang L, Yu C, Sun X, Chan SO. Neurosci Lett. 2018 Nov 1;686:106–11. PubMed Europe PMC Scholia
  27. Regulation of in vivo dynein force production by CDK5 and 14-3-3ε and KIAA0528. Chapman DE, Reddy BJN, Huy B, Bovyn MJ, Cruz SJS, Al-Shammari ZM, et al. Nat Commun. 2019 Jan 16;10(1):228. PubMed Europe PMC Scholia
  28. Numb deficiency causes impaired trafficking of mGlu5 in neurons and autistic-like behaviors. Wang N, Wang DD, Shen Y. Neurosci Lett. 2019 Aug 10;707:134291. PubMed Europe PMC Scholia
  29. Ghrelin up-regulates cartilage-specific genes via the ERK/STAT3 pathway in chondrocytes of patients with adolescent idiopathic scoliosis. Liang ZT, Li J, Rong R, Wang YJ, Xiao LG, Yang GT, et al. Biochem Biophys Res Commun. 2019 Oct 15;518(2):259–65. PubMed Europe PMC Scholia
  30. Nerve growth factor (NGF)-TrkA axis in head and neck squamous cell carcinoma triggers EMT and confers resistance to the EGFR inhibitor erlotinib. Lin C, Ren Z, Yang X, Yang R, Chen Y, Liu Z, et al. Cancer Lett. 2020 Mar 1;472:81–96. PubMed Europe PMC Scholia
  31. Interleukin-27 decreases ghrelin production through signal transducer and activator of transcription 3-mechanistic target of rapamycin signaling. Zhang H, Li Q, Teng Y, Lin Y, Li S, Qin T, et al. Acta Pharm Sin B. 2020 May;10(5):837–49. PubMed Europe PMC Scholia
  32. Tricetin Suppresses Migration and Presenilin-1 Expression of Nasopharyngeal Carcinoma through Akt/GSK-3β Pathway. Ho HY, Lin FCF, Chen PN, Chen MK, Hsin CH, Yang SF, et al. Am J Chin Med. 2020;48(5):1203–20. PubMed Europe PMC Scholia
  33. Evaluation of the Neurogenic Potential in the Rat Inferior Colliculus from Early Postnatal Days Until Adulthood. Engert J, Rak K, Bieniussa L, Scholl M, Hagen R, Voelker J. Mol Neurobiol. 2021 Feb;58(2):719–34. PubMed Europe PMC Scholia
  34. TAZ Represses the Neuronal Commitment of Neural Stem Cells. Robledinos-Antón N, Escoll M, Guan KL, Cuadrado A. Cells. 2020 Oct 2;9(10):2230. PubMed Europe PMC Scholia
  35. Inactive variants of death receptor p75NTR reduce Alzheimer’s neuropathology by interfering with APP internalization. Yi C, Goh KY, Wong LW, Ramanujan A, Tanaka K, Sajikumar S, et al. EMBO J. 2021 Jan 15;40(2):e104450. PubMed Europe PMC Scholia
  36. FAIM Is Regulated by MiR-206, MiR-1-3p and MiR-133b. Coccia E, Masanas M, López-Soriano J, Segura MF, Comella JX, Pérez-García MJ. Front Cell Dev Biol. 2020 Dec 23;8:584606. PubMed Europe PMC Scholia
  37. Clinical and Biological Features of Neuroendocrine Prostate Cancer. Yamada Y, Beltran H. Curr Oncol Rep. 2021 Jan 12;23(2):15. PubMed Europe PMC Scholia
  38. TrkA Interacts with and Phosphorylates STAT3 to Enhance Gene Transcription and Promote Breast Cancer Stem Cells in Triple-Negative and HER2-Enriched Breast Cancers. Regua AT, Aguayo NR, Jalboush SA, Doheny DL, Manore SG, Zhu D, et al. Cancers (Basel). 2021 May 12;13(10):2340. PubMed Europe PMC Scholia
  39. Depletion of Numb and Numblike in Murine Lung Epithelial Cells Ameliorates Bleomycin-Induced Lung Fibrosis by Inhibiting the β-Catenin Signaling Pathway. Ianni A, Hofmann M, Kumari P, Tarighi S, Al-Tamari HM, Görgens A, et al. Front Cell Dev Biol. 2021 May 26;9:639162. PubMed Europe PMC Scholia
  40. RET Regulates Human Medullary Thyroid Cancer Cell Proliferation through CDK5 and STAT3 Activation. Yue CH, Oner M, Chiu CY, Chen MC, Teng CL, Wang HY, et al. Biomolecules. 2021 Jun 9;11(6):860. PubMed Europe PMC Scholia
  41. Knockdown of Lingo-1 by short hairpin RNA promotes cognitive function recovery in a status convulsion model. He R, Han W, Song X, Cheng L, Chen H, Jiang L. 3 Biotech. 2021 Jul;11(7):339. PubMed Europe PMC Scholia
  42. SDF-1/CXCR4 axis promotes osteogenic differentiation of BMSCs through the JAK2/STAT3 pathway. Xiong W, Guo X, Cai X. Folia Histochem Cytobiol. 2021;59(3):187–94. PubMed Europe PMC Scholia
  43. Bioinformatics Prediction and Analysis of MicroRNAs and Their Targets as Biomarkers for Prostate Cancer: A Preliminary Study. Lombe CP, Meyer M, Pretorius A. Mol Biotechnol. 2022 Apr;64(4):401–12. PubMed Europe PMC Scholia
  44. NOTCH4 Exhibits Anti-Inflammatory Activity in Activated Macrophages by Interfering With Interferon-γ and TLR4 Signaling. López-López S, Romero de Ávila MJ, Hernández de León NC, Ruiz-Marcos F, Baladrón V, Nueda ML, et al. Front Immunol. 2021 Dec 1;12:734966. PubMed Europe PMC Scholia
  45. VLDLR and ApoER2 are receptors for multiple alphaviruses. Clark LE, Clark SA, Lin C, Liu J, Coscia A, Nabel KG, et al. Nature. 2022 Feb;602(7897):475–80. PubMed Europe PMC Scholia
  46. Live-Cell Imaging of Single Neurotrophin Receptor Molecules on Human Neurons in Alzheimer’s Disease. Barabás K, Kobolák J, Godó S, Kovács T, Ernszt D, Kecskés M, et al. Int J Mol Sci. 2021 Dec 9;22(24):13260. PubMed Europe PMC Scholia
  47. Numb and Numblike regulate sarcomere assembly and maintenance. Wang B, Yang M, Li S. J Clin Invest. 2022 Feb 1;132(3):e139420. PubMed Europe PMC Scholia
  48. C-X-C motif chemokine ligand 12 (CXCL12)/C-X-C motif chemokine receptor 7(CXCR7) regulates epithelial-mesenchymal transition process and promotes the metastasis of esophageal cancer by activating signal transducer and activator of transcription 3 (STAT3) pathway. Guo J, Tong CY, Shi JG, Li XJ. Bioengineered. 2022 Mar;13(3):7425–38. PubMed Europe PMC Scholia
  49. Characterization of KRC-108 as a TrkA Kinase Inhibitor with Anti-Tumor Effects. Lee HJ, Moon Y, Choi J, Heo JD, Kim S, Nallapaneni HK, et al. Biomol Ther (Seoul). 2022 Jul 1;30(4):360–7. PubMed Europe PMC Scholia
  50. Detection of NTRK Fusions and TRK Expression and Performance of pan-TRK Immunohistochemistry in Routine Diagnostics: Results from a Nationwide Community-Based Cohort. Koopman B, Kuijpers CCHJ, Groen HJM, Timens W, Schuuring E, Willems SM, et al. Diagnostics (Basel). 2022 Mar 9;12(3):668. PubMed Europe PMC Scholia
  51. Direct interaction of TrkA/CD44v3 is essential for NGF-promoted aggressiveness of breast cancer cells. Trouvilliez S, Cicero J, Lévêque R, Aubert L, Corbet C, Van Outryve A, et al. J Exp Clin Cancer Res. 2022 Mar 28;41(1):110. PubMed Europe PMC Scholia
  52. Dendritic distribution of CDK5 mRNA and p35 mRNA, and a glutamate-responsive increase of CDK5/p25 complex contribute to tau hyperphosphorylation. Tanaka T, Ohashi S, Takashima A, Kobayashi S. Biochim Biophys Acta Gen Subj. 2022 Jul;1866(7):130135. PubMed Europe PMC Scholia
  53. Standardized evidence-based approach for assessment of oncogenic and clinical significance of NTRK fusions. Saliba J, Church AJ, Rao S, Danos A, Furtado LV, Laetsch T, et al. Cancer Genet. 2022 Jun;264–265:50–9. PubMed Europe PMC Scholia
  54. The Cell Adhesion Molecule L1 Interacts with Methyl CpG Binding Protein 2 via Its Intracellular Domain. Loers G, Kleene R, Girbes Minguez M, Schachner M. Int J Mol Sci. 2022 Mar 24;23(7):3554. PubMed Europe PMC Scholia
  55. CXCL12 inhibits hair growth through CXCR4. Zheng M, Oh SH, Choi N, Choi YJ, Kim J, Sung JH. Biomed Pharmacother. 2022 Jun;150:112996. PubMed Europe PMC Scholia
  56. An Integrated Perspective of Evolution and Development: From Genes to Function to Ear, Lateral Line and Electroreception. Fritzsch B. Diversity (Basel). 2021 Aug;13(8):364. PubMed Europe PMC Scholia
  57. Differentiation of PC12 cell line into neuron by Valproic acid encapsulated in the stabilized core-shell liposome-chitosan Nano carriers. Kelkawi AHA, Hashemzadeh H, Pashandi Z, Tiraihi T, Naderi-Manesh H. Int J Biol Macromol. 2022 Jun 15;210:252–60. PubMed Europe PMC Scholia
  58. Lck signaling inhibition causes improvement in clinical features of psoriatic inflammation through reduction in inflammatory cytokines in CD4+ T cells in imiquimod mouse model. Al-Harbi NO, Ahmad SF, Almutairi M, Alanazi AZ, Ibrahim KE, Alqarni SA, et al. Cell Immunol. 2022 Jun;376:104531. PubMed Europe PMC Scholia
  59. Colony‑stimulating factor CSF2 mediates the phenotypic plasticity of small‑cell lung cancer by regulating the p‑STAT3/MYC pathway. Li H, Zhong R, He C, Tang C, Cui H, Li R, et al. Oncol Rep. 2022 Jul;48(1):122. PubMed Europe PMC Scholia
  60. Induction of Transcriptional Inhibitor HES1 and the Related Repression of Tumor-Suppressor TXNIP Are Important Components of Cell-Transformation Program Imposed by Oncogenic Kinase NPM-ALK. Zhang Q, Wang HY, Nayak A, Nunez-Cruz S, Slupianek A, Liu X, et al. Am J Pathol. 2022 Aug;192(8):1186–98. PubMed Europe PMC Scholia
  61. The Bioinformatical Identification of Potential Biomarkers in Heart Failure Diagnosis and Treatment. Sheng X, Jin X, Liu Y, Fan T, Zhu Z, Jin J, et al. Genet Res (Camb). 2022 May 16;2022:8727566. PubMed Europe PMC Scholia
  62. Microplastics- and copper-induced changes in neurogenesis and DNA methyltransferases in the early life stages of zebrafish. Santos D, Luzio A, Bellas J, Monteiro SM. Chem Biol Interact. 2022 Aug 25;363:110021. PubMed Europe PMC Scholia
  63. Probiotic Bifidobacterium breve MCC1274 Mitigates Alzheimer’s Disease-Related Pathologies in Wild-Type Mice. Abdelhamid M, Zhou C, Jung CG, Michikawa M. Nutrients. 2022 Jun 19;14(12):2543. PubMed Europe PMC Scholia