ACE inhibitor pathway (WP554)
Homo sapiens
The core of this pathway was elucidated over a century ago and involves the conversion of angiotensinogen to angiotensin I (Ang I) by renin, its subsequent conversion to angiotensin II (Ang II) by angiotensin converting enzyme. Ang II activates the angiotensin II receptor type 1 to induce aldosterone synthesis, increasing water and salt resorption and potassium excretion in the kidney and increasing blood pressure. Source: PharmGKB (https://www.pharmgkb.org/pathway/PA2023) Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP554 CPTAC Assay Portal]
Authors
Caroline F. Thorn , Jinwook.seo , Kristina Hanspers , Alex Pico , Thomas Kelder , Martijn Van Iersel , Egon Willighagen , Christine Chichester , Nuno , Denise Slenter , Martina Summer-Kutmon , and Eric WeitzActivity
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Cited In
- ACE2 correlates with immune infiltrates in colon adenocarcinoma: Implication for COVID-19 (2021).
- Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing (2020).
- PathVisio 3: An Extendable Pathway Analysis Toolbox (2015).
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Organisms
Homo sapiensCommunities
Renal Genomics PathwaysAnnotations
Pathway Ontology
signaling pathway angiotensin signaling pathway ACE inhibitor drug pathwayDisease Ontology
hypertensionCell Type Ontology
mesangial cell| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Bradykinin | Metabolite | hmdb:HMDB0004246 | |
| Ang 1-9 | Metabolite | kegg.compound:C15851 | |
| Ang 1-7 | Metabolite | chemspider:110354 | |
| Angiotensin II | Metabolite | hmdb:HMDB0001035 | |
| ACE inhibitor | Metabolite | chebi:35457 | |
| Deoxycorticosterone | Metabolite | hmdb:HMDB0000016 | |
| Aldosterone | Metabolite | hmdb:HMDB0000037 | |
| Angiotensin I | Metabolite | pubchem.compound:3081372 | |
| Ca2+ | Metabolite | hmdb:HMDB0000464 | |
| Prostacyclin | Metabolite | pubchem.compound:114805 | |
| Ang 1-5 | Metabolite | kegg.compound:C15852 | |
| CYP11B2 | GeneProduct | ncbigene:1585 | |
| ACE2 | GeneProduct | ncbigene:59272 | |
| TGFB1 | GeneProduct | ncbigene:7040 | |
| ACE | GeneProduct | ncbigene:1636 | |
| NOS3 | GeneProduct | ncbigene:4846 | |
| AGTR2 | GeneProduct | ncbigene:186 | |
| NR3C2 | GeneProduct | ncbigene:4306 | |
| KNG1 | GeneProduct | ncbigene:3827 | |
| MAS1 | GeneProduct | ncbigene:4142 | |
| REN | GeneProduct | ncbigene:5972 | |
| BDKRB2 | GeneProduct | ncbigene:624 | |
| CMA1 | GeneProduct | ncbigene:1215 | |
| ACE | GeneProduct | ncbigene:1636 | |
| CTSG | GeneProduct | ncbigene:1511 | |
| BDKRB1 | GeneProduct | ncbigene:623 | |
| AGT | GeneProduct | ncbigene:183 | |
| AGTR1 | GeneProduct | ncbigene:185 | |
| ATP6AP2 | GeneProduct | ncbigene:10159 | |
| ACE | GeneProduct | ncbigene:1636 | |
| ACE2 | GeneProduct | ncbigene:59272 |
References
- The regulation of aldosterone synthase expression. Bassett MH, White PC, Rainey WE. Mol Cell Endocrinol. 2004 Mar 31;217(1–2):67–74. PubMed Europe PMC Scholia
- Pharmacogenetics of antihypertensive drug responses. Schwartz GL, Turner ST. Am J Pharmacogenomics. 2004;4(3):151–60. PubMed Europe PMC Scholia
- Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms. Huang Y, Wongamorntham S, Kasting J, McQuillan D, Owens RT, Yu L, et al. Kidney Int. 2006 Jan;69(1):105–13. PubMed Europe PMC Scholia
- The emerging role of ACE2 in physiology and disease. Hamming I, Cooper ME, Haagmans BL, Hooper NM, Korstanje R, Osterhaus ADME, et al. J Pathol. 2007 May;212(1):1–11. PubMed Europe PMC Scholia
- Effects of renin-angiotensin system inhibition on end-organ protection: can we do better? Weir MR. Clin Ther. 2007 Sep;29(9):1803–24. PubMed Europe PMC Scholia
- The (pro)renin receptor: a new addition to the renin-angiotensin system? Batenburg WW, Jan Danser AH. Eur J Pharmacol. 2008 May 13;585(2–3):320–4. PubMed Europe PMC Scholia
- Are we poised to target ACE2 for the next generation of antihypertensives? Ferreira AJ, Raizada MK. J Mol Med (Berl). 2008 Jun;86(6):685–90. PubMed Europe PMC Scholia
- Mineralocorticoid receptor antagonists and endothelial function. Maron BA, Leopold JA. Curr Opin Investig Drugs. 2008 Sep;9(9):963–9. PubMed Europe PMC Scholia