Serotonin and anxiety-related events (WP3944)

Homo sapiens

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Stress and anxiety disorders are risk factors for depression and these behaviours are modulated by corticotropin releasing factor (CRFR1) and serotonin (5-HT2R) receptors. (Source: Berg et al "5-Hydroxytryptamine type 2A receptors regulate cyclic AMP accumulation in a neuronal cell line by protein kinase C-dependent and calcium/calmodulin-dependent mechanisms"). Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3944 CPTAC Assay Portal]

Authors

Kristina Hanspers , Egon Willighagen , and Eric Weitz

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

signaling pathway disease pathway

Cell Type Ontology

cerebral cortex neuron

Disease Ontology

anxiety disorder

Participants
Query Drugst.One

Label Type Compact URI Comment
Serotonin Metabolite hmdb:HMDB0000259
Ketanserin Metabolite chebi:6123
HTR2A GeneProduct ensembl:ENSG00000102468 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000034997
ARC GeneProduct ensembl:ENSG00000198576 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022602
HTR2C GeneProduct ensembl:ENSG00000147246 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000041380
HTR1A GeneProduct ensembl:ENSG00000178394 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021721
FOS GeneProduct ensembl:ENSG00000170345 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021250
PLEK GeneProduct ensembl:ENSG00000115956 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020120
PPP3CA GeneProduct ensembl:ENSG00000138814 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:107164
PRKCB GeneProduct ensembl:ENSG00000166501 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000052889
PLCD4 GeneProduct ensembl:ENSG00000115556 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000026173
GRIN2D GeneProduct ensembl:ENSG00000105464 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000002771
NLGN1 GeneProduct ensembl:ENSG00000169760 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000063887
CRHR1 GeneProduct ensembl:ENSG00000120088 Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000018634
CRH Protein ensembl:ENSG00000147571 Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q8CIT0

References

  1. 5-Hydroxytryptamine type 2A receptors regulate cyclic AMP accumulation in a neuronal cell line by protein kinase C-dependent and calcium/calmodulin-dependent mechanisms. Berg KA, Clarke WP, Chen Y, Ebersole BJ, McKay RD, Maayani S. Mol Pharmacol. 1994 May;45(5):826–36. PubMed Europe PMC Scholia
  2. CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling. Magalhaes AC, Holmes KD, Dale LB, Comps-Agrar L, Lee D, Yadav PN, et al. Nat Neurosci. 2010 May;13(5):622–9. PubMed Europe PMC Scholia
  3. Enhanced function of prefrontal serotonin 5-HT(2) receptors in a rat model of psychiatric vulnerability. Benekareddy M, Goodfellow NM, Lambe EK, Vaidya VA. J Neurosci. 2010 Sep 8;30(36):12138–50. PubMed Europe PMC Scholia