Mitochondrial complex III assembly (WP4921)

Homo sapiens

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Complex III or quinol-cytochrome c reductase performs electron transfer coupled to proton pumping. It occurs as a symmetrical, tightly bound dimer (referred to as cIII2). This dimerisation occurs prior to the pre CIII complex formation, annotated as pre-CIII(2). Each monomer is composed of a catalytic core containing MT-CYB, CYC1 and UQCRFS1. An additional seven subunits are required for stability and/or correct assembly of the enzyme, but are not involved in the catalysis, but .

Authors

Anna Baya Meuleman and Eric Weitz

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

electron transport chain pathway oxidative phosphorylation pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
heme b Metabolite chebi:60344
2Fe-2S Metabolite chebi:30408
heme b Metabolite chebi:60344
2Fe-2S Metabolite chebi:30408
UQCC3 GeneProduct ensembl:ENSG00000204922
UQCC2 GeneProduct ensembl:ENSG00000137288
UQCRH GeneProduct ensembl:ENSG00000173660
UQCRC2 GeneProduct ensembl:ENSG00000140740
LYRM7 GeneProduct ensembl:ENSG00000186687
UQCR11 GeneProduct ensembl:ENSG00000127540
UQCRB GeneProduct ensembl:ENSG00000156467
UQCRC1 GeneProduct ensembl:ENSG00000010256
MT-CYB GeneProduct ensembl:ENSG00000198727
UQCRQ GeneProduct ensembl:ENSG00000164405
UQCRFS1 GeneProduct ensembl:ENSG00000169021
CYC1 GeneProduct ensembl:ENSG00000179091
BCS1L GeneProduct ensembl:ENSG00000074582
UQCC1 GeneProduct ensembl:ENSG00000101019
TTC19 GeneProduct ensembl:ENSG00000011295
UQCR10 GeneProduct ensembl:ENSG00000184076
UQCC2 GeneProduct ensembl:ENSG00000137288
MT-CYB GeneProduct ensembl:ENSG00000198727
UQCC1 GeneProduct ensembl:ENSG00000101019
UQCC3 GeneProduct ensembl:ENSG00000204922
UQCC2 GeneProduct ensembl:ENSG00000137288
UQCC1 GeneProduct ensembl:ENSG00000101019
UQCC3 GeneProduct ensembl:ENSG00000204922
MT-CYB GeneProduct ensembl:ENSG00000198727
UQCRB GeneProduct ensembl:ENSG00000156467
UQCRQ GeneProduct ensembl:ENSG00000164405
UQCC3 GeneProduct ensembl:ENSG00000204922
MT-CYB GeneProduct ensembl:ENSG00000198727
UQCRB GeneProduct ensembl:ENSG00000156467
UQCRQ GeneProduct ensembl:ENSG00000164405
UQCRH GeneProduct ensembl:ENSG00000173660
UQCRC2 GeneProduct ensembl:ENSG00000140740
UQCRC1 GeneProduct ensembl:ENSG00000010256
CYC1 GeneProduct ensembl:ENSG00000179091
LYRM7 GeneProduct ensembl:ENSG00000186687
UQCRFS1 GeneProduct ensembl:ENSG00000169021
MT-CYB GeneProduct ensembl:ENSG00000198727
UQCRB GeneProduct ensembl:ENSG00000156467
UQCRQ GeneProduct ensembl:ENSG00000164405
UQCRH GeneProduct ensembl:ENSG00000173660
UQCRC2 GeneProduct ensembl:ENSG00000140740
UQCRC1 GeneProduct ensembl:ENSG00000010256
CYC1 GeneProduct ensembl:ENSG00000179091
UQCR11 GeneProduct ensembl:ENSG00000127540
UQCR10 GeneProduct ensembl:ENSG00000184076
LYRM7 GeneProduct ensembl:ENSG00000186687
UQCRFS1 GeneProduct ensembl:ENSG00000169021
BCS1L GeneProduct ensembl:ENSG00000074582
MT-CYB GeneProduct ensembl:ENSG00000198727
UQCRB GeneProduct ensembl:ENSG00000156467
UQCRQ GeneProduct ensembl:ENSG00000164405
UQCRH GeneProduct ensembl:ENSG00000173660
UQCRC2 GeneProduct ensembl:ENSG00000140740
UQCRC1 GeneProduct ensembl:ENSG00000010256
CYC1 GeneProduct ensembl:ENSG00000179091
UQCR11 GeneProduct ensembl:ENSG00000127540
UQCR10 GeneProduct ensembl:ENSG00000184076
LYRM7 GeneProduct ensembl:ENSG00000186687
UQCRFS1 GeneProduct ensembl:ENSG00000169021
BCS1L GeneProduct ensembl:ENSG00000074582
TTC19 GeneProduct ensembl:ENSG00000011295

References

  1. Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes. Signes A, Fernandez-Vizarra E. Essays Biochem. 2018 Jul 20;62(3):255–70. PubMed Europe PMC Scholia