Wnt signaling - Q neuroblast migration (WP2888)

Caenorhabditis elegans

One of the functions of the Wnt-signaling pathway in the nematode Caenorhabditis elegans (C. elegans) is to control the proper anterior-posterior axis migration of descendants of the QL and QR neuroblasts. In wild type animals, Wnt signaling is activated in the QL neuroblast to induce expression of the Hox gene mab-5 resulting in the appropriate posterior migration of QL descendants. Any disruption in the Wnt signaling pathway leading to mab-5 expression results in erroneous anterior migration of QL neuroblast descendants.


Christian Grove , Martina Summer-Kutmon , and Eric Weitz


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Caenorhabditis elegans



Pathway Ontology

Wnt signaling pathway


Label Type Compact Identifier Comment
mab-5/Hox GeneProduct wormbase:C08C3.3
PRY-1 GeneProduct wormbase:C37A5.9
MAB-5/Hox GeneProduct wormbase:C08C3.3
LIN-17/Frizzled GeneProduct wormbase:Y71F9B.5
MIG-14/MOM-3Porcupine GeneProduct wormbase:R06B9.6
MIG-1/Frizzled GeneProduct wormbase:Y34D9B.1
MIG-5 GeneProduct wormbase:WBGene00003241
mab-5/Hox GeneProduct wormbase:C08C3.3
MAB-5/Hox GeneProduct wormbase:C08C3.3
PRY-1 GeneProduct wormbase:C37A5.9
BAR-1/beta-Catenin GeneProduct wormbase:C54D1.6
BAR-1/beta-Catenin GeneProduct wormbase:C54D1.6
EGL-20/Wnt Protein wormbase:W08D2.1
EGL-20/Wnt Protein wormbase:W08D2.1


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