Blood-based neuroinflammation markers (WP5548)

Homo sapiens

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This figure presents a comprehensive overview of molecular markers associated with neuroinflammation, specifically focusing on potential blood-based markers. Markers are organized by biological function and relevance to specific neuroimmune processes. The markers are grouped into seven categories, including systemic innate-immune mediators; blood–brain barrier (BBB) disruption and vascular endothelial injury; glial activation, which is subdivided into astrocyte and microglial activation; neuromodulators and neuropeptides; neuronal injury markers; the neurotoxic metabolite quinolinic acid, a neuroactive product of the kynurenine pathway; and neurotrophic factors.

Authors

Kristof-Kirps , Martina Summer-Kutmon , and Eric Weitz

Activity

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

cytokine and chemokine mediated signaling pathway nervous system disease pathway immune system disease pathway

Cell Type Ontology

blood cell

Disease Ontology

long COVID

Participants
Query Drugst.One

Label Type Compact URI Comment
Quinolinic acid Metabolite chebi:16675
ADM Protein uniprot:P35318
CX3CL1 Protein uniprot:P78423
CRP Protein uniprot:P02741
CCL11 Protein uniprot:P51671
CCL5 Protein uniprot:P13501
S100B Protein uniprot:P04271
TREM2 Protein uniprot:Q9NZC2
DBI Protein uniprot:P07108
CHI3L1 Protein uniprot:P36222
GFAP Protein uniprot:P14136
OLR1 Protein uniprot:P78380
NEFL Protein uniprot:P07196
TSPO Protein uniprot:P30536
BDNF Protein uniprot:P23560
TAC1 Protein uniprot:P20366
CCL23 Protein uniprot:P55773
CCL2 Protein uniprot:P13500
IL1B Protein uniprot:P01584
IL6 Protein uniprot:P05231
GRN Protein uniprot:P28799
TREM1 Protein uniprot:Q9NP99
TNF Protein uniprot:P01375

References

  1. Serum MCP-1 levels are increased in mild cognitive impairment and mild Alzheimer’s disease. Galimberti D, Fenoglio C, Lovati C, Venturelli E, Guidi I, Corrà B, et al. Neurobiol Aging. 2006 Dec;27(12):1763–8. PubMed Europe PMC Scholia
  2. Serum BDNF, TNF-alpha and IL-1beta levels in dementia patients: comparison between Alzheimer’s disease and vascular dementia. Yasutake C, Kuroda K, Yanagawa T, Okamura T, Yoneda H. Eur Arch Psychiatry Clin Neurosci. 2006 Oct;256(7):402–6. PubMed Europe PMC Scholia
  3. Changes in the levels of plasma soluble fractalkine in patients with mild cognitive impairment and Alzheimer’s disease. Kim TS, Lim HK, Lee JY, Kim DJ, Park S, Lee C, et al. Neurosci Lett. 2008 May 9;436(2):196–200. PubMed Europe PMC Scholia
  4. Mechanism for quinolinic acid cytotoxicity in human astrocytes and neurons. Braidy N, Grant R, Adams S, Brew BJ, Guillemin GJ. Neurotox Res. 2009 Jul;16(1):77–86. PubMed Europe PMC Scholia
  5. Serum levels of S100B and NSE proteins in Alzheimer’s disease patients. Chaves ML, Camozzato AL, Ferreira ED, Piazenski I, Kochhann R, Dall’Igna O, et al. J Neuroinflammation. 2010 Jan 27;7:6. PubMed Europe PMC Scholia
  6. Plasma level of chitinase 3-like 1 protein increases in patients with early Alzheimer’s disease. Choi J, Lee HW, Suk K. J Neurol. 2011 Dec;258(12):2181–5. PubMed Europe PMC Scholia
  7. C-reactive protein increases BBB permeability: implications for obesity and neuroinflammation. Hsuchou H, Kastin AJ, Mishra PK, Pan W. Cell Physiol Biochem. 2012;30(5):1109–19. PubMed Europe PMC Scholia
  8. Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury. Martens LH, Zhang J, Barmada SJ, Zhou P, Kamiya S, Sun B, et al. J Clin Invest. 2012 Nov;122(11):3955–9. PubMed Europe PMC Scholia
  9. Blocking neurogenic inflammation for the treatment of acute disorders of the central nervous system. Lewis KM, Turner RJ, Vink R. Int J Inflam. 2013;2013:578480. PubMed Europe PMC Scholia
  10. Correlation of adrenomedullin gene expression in peripheral blood leukocytes with severity of ischemic stroke. Liu J, Yan J, Greer JM, Read SJ, Henderson RD, Rose SE, et al. Int J Neurosci. 2014 Apr;124(4):271–80. PubMed Europe PMC Scholia
  11. Quinolinic acid: an endogenous neurotoxin with multiple targets. Lugo-Huitrón R, Ugalde Muñiz P, Pineda B, Pedraza-Chaverrí J, Ríos C, Pérez-de la Cruz V. Oxid Med Cell Longev. 2013;2013:104024. PubMed Europe PMC Scholia
  12. The 18 kDa translocator protein, microglia and neuroinflammation. Liu GJ, Middleton RJ, Hatty CR, Kam WWY, Chan R, Pham T, et al. Brain Pathol. 2014 Nov;24(6):631–53. PubMed Europe PMC Scholia
  13. Impact of Cytokines and Chemokines on Alzheimer’s Disease Neuropathological Hallmarks. Domingues C, da Cruz E Silva OAB, Henriques AG. Curr Alzheimer Res. 2017;14(8):870–82. PubMed Europe PMC Scholia
  14. Soluble TREM2 and biomarkers of central and peripheral inflammation in neurodegenerative disease. Bekris LM, Khrestian M, Dyne E, Shao Y, Pillai JA, Rao SM, et al. J Neuroimmunol. 2018 Jun 15;319:19–27. PubMed Europe PMC Scholia
  15. Astrocyte Biomarkers in Alzheimer’s Disease. Carter SF, Herholz K, Rosa-Neto P, Pellerin L, Nordberg A, Zimmer ER. Trends Mol Med. 2019 Feb;25(2):77–95. PubMed Europe PMC Scholia
  16. Microglial Progranulin: Involvement in Alzheimer’s Disease and Neurodegenerative Diseases. Mendsaikhan A, Tooyama I, Walker DG. Cells. 2019 Mar 11;8(3):230. PubMed Europe PMC Scholia
  17. Serum neurofilament light chain reflects inflammation-driven neurodegeneration and predicts delayed brain volume loss in early stage of multiple sclerosis. Srpova B, Uher T, Hrnciarova T, Barro C, Andelova M, Michalak Z, et al. Mult Scler. 2021 Jan;27(1):52–60. PubMed Europe PMC Scholia
  18. Serum DBI and biomarkers of neuroinflammation in Alzheimer’s disease and delirium. Conti E, Andreoni S, Tomaselli D, Storti B, Brovelli F, Acampora R, et al. Neurol Sci. 2021 Mar;42(3):1003–7. PubMed Europe PMC Scholia
  19. Association of plasma YKL-40 with brain amyloid-β levels, memory performance, and sex in subjective memory complainers. Vergallo A, Lista S, Lemercier P, Chiesa PA, Zetterberg H, Blennow K, et al. Neurobiol Aging. 2020 Dec;96:22–32. PubMed Europe PMC Scholia
  20. Regulated upon activation, normal T cell expressed and secreted (RANTES) levels in the peripheral blood of patients with Alzheimer’s disease. Vacinova G, Vejražkova D, Rusina R, Holmerová I, Vaňková H, Jarolímová E, et al. Neural Regen Res. 2021 Apr;16(4):796–800. PubMed Europe PMC Scholia
  21. Eotaxin-1 (CCL11) in neuroinflammatory disorders and possible role in COVID-19 neurologic complications. Nazarinia D, Behzadifard M, Gholampour J, Karimi R, Gholampour M. Acta Neurol Belg. 2022 Aug;122(4):865–9. PubMed Europe PMC Scholia
  22. Serum Brain-Derived Neurotrophic Factor (BDNF) in COVID-19 Patients and its Association with the COVID-19 Manifestations. Asgarzadeh A, Fouladi N, Asghariazar V, Sarabi SF, Khiavi HA, Mahmoudi M, et al. J Mol Neurosci. 2022 Sep;72(9):1820–30. PubMed Europe PMC Scholia
  23. TREM1 as a novel prognostic biomarker and tumor immune microenvironment evaluator in glioma. Lu Q, Xie Y, Qi X, Yang S. Medicine (Baltimore). 2023 Dec 1;102(48):e36410. PubMed Europe PMC Scholia
  24. How S100B crosses brain barriers and why it is considered a peripheral marker of brain injury. Gayger-Dias V, Vizuete AF, Rodrigues L, Wartchow KM, Bobermin L, Leite MC, et al. Exp Biol Med (Maywood). 2023 Nov;248(22):2109–19. PubMed Europe PMC Scholia
  25. Blood-Based Biomarkers in Alzheimer’s Disease: Advancing Non-Invasive Diagnostics and Prognostics. Dhauria M, Mondal R, Deb S, Shome G, Chowdhury D, Sarkar S, et al. Int J Mol Sci. 2024 Oct 10;25(20):10911. PubMed Europe PMC Scholia
  26. Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 (LOX-1): A Potential Therapeutic Target in Ischemic Stroke. Hu Y, Li Y, Luo Y, Wang N, Zheng Y. Transl Stroke Res. 2024 Nov 22;10.1007/s12975-024-01307-z. PubMed Europe PMC Scholia