Trehalose anabolism (WP398)

Saccharomyces cerevisiae

Trehalose is a storage carbohydrate that can either be synthesized or obtained from the external environment. To be utilized as a carbon source, trehalase (EC: must convert trehalose and water into two molecules of glucose. S. cerevisiae has two trehalase enzymes, one is an acid trehalase encoded by ATH1 and the other is a neutral trehalase encoded by NTH1. The name "acid" or "neutral" are based on the optimal pH of each enzyme (pH 4.5-5.0 and pH 6.8-7.0, respectively).


Meredith Braymer , Daniela Digles , Egon Willighagen , Denise Slenter , and Eric Weitz


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Saccharomyces cerevisiae



Pathway Ontology

trehalose biosynthetic pathway


Label Type Compact URI Comment
UDP Metabolite chebi:17659
UTP Metabolite chebi:46398
alpha,alpha-trehalose 6-phosphate Metabolite wikidata:Q27102967
H2O Metabolite chebi:15377
UDP-D-glucose Metabolite chebi:46229
pyrophosphate Metabolite cas:2466-09-3
glucose-1-phosphate Metabolite chebi:16077
beta-D-Glucose Metabolite chebi:15903
phosphate Metabolite cas:14265-44-2
glucose-6-phosphate Metabolite chebi:75150
trehalose Metabolite cas:99-20-7
H2O Metabolite chebi:15377
PGM2 GeneProduct sgd:S000004711
UGP1 GeneProduct sgd:S000001518
TPS2 GeneProduct sgd:S000002481
TSL1 GeneProduct sgd:S000004566
PGM1 GeneProduct sgd:S000001610
TPS3 GeneProduct sgd:S000004874
TPS1 GeneProduct sgd:S000000330
YHL012W GeneProduct sgd:S000001004
ATH1 GeneProduct ensembl:YPR026W acid trehalase
NTH1 GeneProduct ensembl:YDR001C neutral trehalase


  1. Reserve carbohydrates metabolism in the yeast Saccharomyces cerevisiae. François J, Parrou JL. FEMS Microbiol Rev. 2001 Jan;25(1):125–45. PubMed Europe PMC Scholia