Glucocorticoid effect on target gene expression (WP1963)

Rattus norvegicus

This pathway provides a clear view of the effects of Glucocorticoids on target gene expression when binding to the GR (glucocorticoid receptor). Inhibiting and activiting effects are given as a result of target gene activation. It summarizes the article of Pelaia et al, 2002, which explains the pathway very detailed.

Authors

Rianne Fijten , Kristina Hanspers , Daniela Digles , Egon Willighagen , Martina Summer-Kutmon , and Eric Weitz

Activity

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Cited In

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Organisms

Rattus norvegicus

Communities

Annotations

Pathway Ontology

glucocorticoid signaling pathway

Participants

Label Type Compact URI Comment
Glucocorticoids Metabolite chebi:24261
Glucocorticoids Metabolite chebi:24261
Glucocorticoids Metabolite chebi:24261
Glucocorticoids Metabolite chebi:24261
Glucocorticoids Metabolite chebi:24261
p59 GeneProduct ncbigene:260321
GITR GeneProduct ensembl:ENSRNOG00000022012
COX-2 GeneProduct ensembl:ENSRNOG00000030371
phospholipase A2 GeneProduct ensembl:ENSRNOG00000002657
beta2 adrenergic receptor GeneProduct ensembl:ENSRNOG00000019217
Glucocorticoid Receptor GeneProduct ncbigene:24413
Hsp70 GeneProduct ensembl:ENSRNOG00000016596
Rras GeneProduct ensembl:ENSRNOG00000037247
Glucocorticoid Receptor GeneProduct ncbigene:24413
Hsp90aa1 GeneProduct ensembl:ENSRNOG00000007219
Hsp90ab1 GeneProduct ensembl:ENSRNOG00000019834
Glucocorticoid Receptor GeneProduct ncbigene:24413
Rras GeneProduct ensembl:ENSRNOG00000037247
Hsp70 GeneProduct ensembl:ENSRNOG00000016596
p59 GeneProduct ncbigene:260321
Hsp90aa1 GeneProduct ensembl:ENSRNOG00000007219
Hsp90ab1 GeneProduct ensembl:ENSRNOG00000019834
Glucocorticoid Receptor GeneProduct ncbigene:24413
Rras GeneProduct ensembl:ENSRNOG00000037247
Hsp70 GeneProduct ensembl:ENSRNOG00000016596
p59 GeneProduct ncbigene:260321
Hsp90aa1 GeneProduct ensembl:ENSRNOG00000007219
Hsp90ab1 GeneProduct ensembl:ENSRNOG00000019834
Glucocorticoid Receptor GeneProduct ncbigene:24413
Nf-kB, etc GeneProduct ensembl:ENSRNOG00000023258
Glucocorticoid Receptor GeneProduct ncbigene:24413
Nf-kB, etc GeneProduct ensembl:ENSRNOG00000023258
IkB-alpha GeneProduct ensembl:ENSRNOG00000007390
lipocortin-1 GeneProduct ensembl:ENSRNOG00000017469
GILZ GeneProduct ensembl:ENSRNOG00000056135
Nf-kB GeneProduct ensembl:ENSRNOG00000023258

References

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  5. Regulation of beta 2-adrenergic receptors and the implications for bronchial asthma: an update. Pelaia G, Marsico SA. Monaldi Arch Chest Dis. 1994 Apr;49(2):125–30. PubMed Europe PMC Scholia
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