Pantothenate and coenzyme A biosynthesis (WP462)
Saccharomyces cerevisiae
Coenzyme A is synthesized from pantothenate, which is made from beta-alanine and pantoate deriving from spermine and 2-keto-iosvalerate, respectively.
Authors
Meredith Braymer , Daniela Digles , Egon Willighagen , Scott Norton , Eric Weitz , Alex Pico , and Kristina HanspersActivity
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Organisms
Saccharomyces cerevisiaeCommunities
Annotations
Pathway Ontology
classic metabolic pathway coenzyme A biosynthetic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| 2-dehydropantoate | Metabolite | chebi:11561 | |
| H2O | Metabolite | hmdb:HMDB02111 | |
| pantothenate | Metabolite | chebi:29032 | |
| beta-alanine | Metabolite | chebi:57966 | |
| 2-keto-isovalerate | Metabolite | chebi:11851 | |
| 3-aminopropanal | Metabolite | hmdb:HMDB01106 | |
| pantoate | Metabolite | chebi:15980 | |
| THF | Metabolite | kegg.compound:C03541 | |
| NADH | Metabolite | cas:53-84-9 | |
| 5,10-methylene-THF | Metabolite | cas:31690-11-6 | |
| NADPH | Metabolite | cas:53-57-6 | |
| diphosphate | Metabolite | chebi:29888 | |
| AMP | Metabolite | chebi:456215 | |
| H2O2 | Metabolite | chebi:16240 | |
| spermine | Metabolite | cas:71-44-3 | |
| H+ | Metabolite | chebi:15378 | |
| spermidine | Metabolite | chebi:57834 | |
| NADP+ | Metabolite | chebi:58349 | |
| O2 | Metabolite | chebi:15379 | |
| NAD+ | Metabolite | chebi:57540 | |
| ATP | Metabolite | cas:1927-31-7 | |
| pantetheine 4'-phosphate | Metabolite | chebi:61723 | |
| 4'-phosphopantothenate | Metabolite | chebi:10986 | |
| 4'-phospho-N-pantothenoylcysteine | Metabolite | chebi:59458 | |
| CMP | Metabolite | chebi:60377 | |
| L-cysteine | Metabolite | cas:52-90-4 | |
| CO2 | Metabolite | chebi:16526 | |
| ADP | Metabolite | cas:58-64-0 | |
| dephospho-CoA | Metabolite | cas:3633-59-8 | |
| Coenzyme A | Metabolite | cas:64885-97-8 | |
| CTP | Metabolite | chebi:37563 | |
| FSM1 | GeneProduct | sgd:S000004622 | |
| ALD3 | GeneProduct | sgd:S000004779 | |
| ALD2 | GeneProduct | sgd:S000004780 | |
| PAN5 | GeneProduct | sgd:S000001105 | |
| PAN6 | GeneProduct | sgd:S000001407 | |
| ECM31 | GeneProduct | sgd:S000000380 | |
| CAB1 | GeneProduct | sgd:S000002939 | |
| SIS2 | GeneProduct | sgd:S000001780 | |
| VHS3 | GeneProduct | sgd:S000005580 | |
| CAB4 | GeneProduct | sgd:S000003509 | |
| CAB5 | GeneProduct | sgd:S000002604 | |
| CAB3 | GeneProduct | sgd:S000001571 | |
| CAB2 | GeneProduct | sgd:S000001345 |