Altered glycosylation of MUC1 in tumor microenvironment (WP4480)

Homo sapiens

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Altered MUC1 glycosylation extends to its role as a promoter of chronic inflammatory conditions that lead to malignant transformation and cancer progression.

Authors

Laurent Winckers , Kristina Hanspers , Eric Weitz , and Egon Willighagen

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

CPTAC PancCanNet

Annotations

Pathway Ontology

disease pathway cancer pathway

Cell Type Ontology

T cell dendritic cell macrophage

Disease Ontology

cancer

Participants
Query Drugst.One

Label Type Compact URI Comment
IkKB GeneProduct ncbigene:8517
TNF GeneProduct ncbigene:7124
IkKA GeneProduct ncbigene:1147
IkKG GeneProduct ncbigene:3551
IkBA GeneProduct ncbigene:4792
RELA GeneProduct ncbigene:5970
IL6 GeneProduct ncbigene:3569
MUC1 GeneProduct ncbigene:4582
NFKB1 GeneProduct ncbigene:4790
NFKB1 GeneProduct ncbigene:4790
RELA GeneProduct ncbigene:5970
MUC1 GeneProduct ncbigene:4582
RELA GeneProduct ncbigene:5970
NFKB1 GeneProduct ncbigene:4790
IkBA GeneProduct ncbigene:4792

References

  1. Introduction to NF-kappaB: players, pathways, perspectives. Gilmore TD. Oncogene. 2006 Oct 30;25(51):6680–4. PubMed Europe PMC Scholia
  2. Intra- and Extra-Cellular Events Related to Altered Glycosylation of MUC1 Promote Chronic Inflammation, Tumor Progression, Invasion, and Metastasis. Cascio S, Finn OJ. Biomolecules. 2016 Oct 13;6(4):39. PubMed Europe PMC Scholia