Female steroid hormones in cardiomyocyte energy metabolism (WP5318)

Homo sapiens

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Estrogen and Progesterone affect energy metabolism in cardiomyocytes.

Authors

Mehaa Prabakar , Natalie Varahram , Liana Tyrrell , Egon Willighagen , Andra Waagmeester , and Alex Pico

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

classic metabolic pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Tamoxifen Metabolite chebi:41774
cAMP Metabolite chebi:17489
Estrogen Metabolite chebi:50114
Estrogen Metabolite chebi:50114
Estrogen Metabolite chebi:50114
Estrogen Metabolite chebi:50114
MTP GeneProduct ensembl:ENSG00000138823
cTNL GeneProduct kegg.genes:hsa:1514
FoxO1 GeneProduct uniprot:UP000005640
GLUT4 GeneProduct ensembl:ENSG00000181856
ppara GeneProduct ensembl:ENSG00000186951
HADHB GeneProduct ensembl:ENSG00000138029
GATA4 GeneProduct ensembl:ENSG00000181856
MYH6 GeneProduct uniprot:UP000005640
Inhibition of TNF-a GeneProduct uniprot:UP000005640
HADHB GeneProduct ensembl:ENSG00000138029
GLUT4 GeneProduct ensembl:ENSG00000181856
ROS GeneProduct uniprot:UP000002494
acadm GeneProduct ensembl:ENSG00000117054
Elk-1 GeneProduct uniprot:UP000005640
MEF2 GeneProduct uniprot:UP0000005640
GLUT1 GeneProduct ensembl:ENSG00000181856
PKB Protein ensembl:ENSG00000105221
Apob-lipoprotein Protein ensembl:ENSG00000084674
LKB1 Protein ensembl:ENSG00000118046
ERa Protein uniprot:P03372
Troponin Protein uniprot:UP000005640
PGC-1α Protein uniprot:Q86YN6
RyR2 Protein ensembl:ENST000006099119.1
eNOS Protein ensembl:ENSG00000164867
PPARα Protein uniprot:Q07869
MCAD Protein uniprot:P11310
ATP citrate synthase Protein uniprot:P53396
NOS3 Protein ensembl:ENSG00000164867
ERRa Protein uniprot:P11474
ERRa Protein uniprot:P11474
ERb Protein uniprot:P11474
Progesterone Protein uniprot:P11474
PGR Protein uniprot:P11474
ERa Protein uniprot:P03372
ERa Protein uniprot:P03372
ERa Protein uniprot:P03372

References

  1. PGC-1 upregulation via estrogen receptors: a common mechanism of salutary effects of estrogen and flutamide on heart function after trauma-hemorrhage. Hsieh YC, Yang S, Choudhry MA, Yu HP, Rue LW 3rd, Bland KI, et al. Am J Physiol Heart Circ Physiol. 2005 Dec;289(6):H2665-72. PubMed Europe PMC Scholia
  2. Muscle GLUT4 regulation by estrogen receptors ERbeta and ERalpha. Barros RPA, Machado UF, Warner M, Gustafsson JA. Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1605–8. PubMed Europe PMC Scholia
  3. Functions of AMP-activated protein kinase in adipose tissue. Daval M, Foufelle F, Ferré P. J Physiol. 2006 Jul 1;574(Pt 1):55–62. PubMed Europe PMC Scholia
  4. Transcriptional control of energy homeostasis by the estrogen-related receptors. Giguère V. Endocr Rev. 2008 Oct;29(6):677–96. PubMed Europe PMC Scholia
  5. Estrogen receptor alpha interacts with mitochondrial protein HADHB and affects beta-oxidation activity. Zhou Z, Zhou J, Du Y. Mol Cell Proteomics. 2012 Jul;11(7):M111.011056. PubMed Europe PMC Scholia
  6. Estrogen-related receptor α (ERRα) and ERRγ are essential coordinators of cardiac metabolism and function. Wang T, McDonald C, Petrenko NB, Leblanc M, Wang T, Giguere V, et al. Mol Cell Biol. 2015 Apr;35(7):1281–98. PubMed Europe PMC Scholia
  7. Glucose Transporters in Cardiac Metabolism and Hypertrophy. Shao D, Tian R. Compr Physiol. 2015 Dec 15;6(1):331–51. PubMed Europe PMC Scholia
  8. Cardiomyocyte Regulation of Systemic Lipid Metabolism by the Apolipoprotein B-Containing Lipoproteins in Drosophila. Lee S, Bao H, Ishikawa Z, Wang W, Lim HY. PLoS Genet. 2017 Jan 17;13(1):e1006555. PubMed Europe PMC Scholia
  9. The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy. Yuan J, Dong X, Yap J, Hu J. J Hematol Oncol. 2020 Aug 17;13(1):113. PubMed Europe PMC Scholia
  10. PPAR control of metabolism and cardiovascular functions. Montaigne D, Butruille L, Staels B. Nat Rev Cardiol. 2021 Dec;18(12):809–23. PubMed Europe PMC Scholia