mRNA vaccine activation of dendritic cell and induction of IFN-1 (WP5187)

Homo sapiens

Open in new tab
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
After uptake, mRNA is translated into spike protein and presented as cell-surface MHC-bound peptides to CD4+ and CD8+ T cells. Cytosolic sensing of RNA by RIG-I and MDA5 plus TLR binding within endosomes leads to activation of IFN regulatory factor 3/7 (IRF3/7) and nuclear factor κB (NF-κB), which bind to DNA inducing gene transcription, and production of IFN-I and proinflammatory cytokines, respectively

Authors

Nhung Pham , Eric Weitz , Egon Willighagen , and Alex Pico

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

COVID-19

Annotations

Pathway Ontology

disease pathway

Disease Ontology

COVID-19

Cell Type Ontology

dendritic cell CD8-positive, alpha-beta T cell CD4-positive, alpha-beta T cell

Participants
Query Drugst.One

Label Type Compact URI Comment
Spike Protein Protein uniprot:P0DTC2
S peptide presentation Protein uniprot:Q95460
MAVS Protein uniprot:Q7Z434
IRF-7 Protein uniprot:Q92985
IRF3 Protein uniprot:Q14653
RIG-I (DDX58) Protein uniprot:O95786
MDA5 Protein uniprot:Q9BYX4
T cell receptor Protein uniprot:P01848
TLR3 Protein uniprot:O15455
NF-kB Protein uniprot:Q9Y6Q6
TLR7 Protein uniprot:Q9NYK1
TLR8 Protein uniprot:Q9NR97
S peptide presentation Protein uniprot:Q95460
T cell receptor Protein uniprot:P01848

References

  1. COVID-19 vaccine side effects: The positives about feeling bad. Sprent J, King C. Sci Immunol. 2021 Jun 22;6(60):eabj9256. PubMed Europe PMC Scholia