Cell cycle (WP1083)

Bos taurus

The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle. Sources: [http://en.wikipedia.org/wiki/Cell_cycle Wikipedia:Cell cycle], [http://www.genome.ad.jp/kegg/pathway/hsa/hsa04110.html KEGG]

Authors

Martijn Van Iersel , Martina Summer-Kutmon , Egon Willighagen , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

cell cycle pathway, mitotic

Participants

Label Type Compact URI Comment
BUB1B GeneProduct ensembl:ENSBTAG00000007237 BUB1B; BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:701
ATM GeneProduct ensembl:ENSBTAG00000003111 ATM; ataxia telangiectasia mutated (includes complementation groups A C and D) [EC:2.7.1.37]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:472
ABL1 GeneProduct ensembl:ENSBTAG00000017976 ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1 [EC:2.7.1.112
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:25
ATR GeneProduct ensembl:ENSBTAG00000011529 ATR; ataxia telangiectasia and Rad3 related
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:545
MAD2L2 GeneProduct ensembl:ENSBTAG00000013275 MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10459
BUB1 GeneProduct ensembl:ENSBTAG00000021181 BUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:699
BUB3 GeneProduct ensembl:ENSBTAG00000017913 BUB3; BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9184
EP300 GeneProduct ensembl:ENSBTAG00000016198 EP300; E1A binding protein p300
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2033
WEE1 GeneProduct ensembl:ENSBTAG00000005278 WEE1; WEE1+ homolog (S. pombe) [EC:2.7.1.112]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7465
PTTG1 GeneProduct ensembl:ENSBTAG00000047322 PTTG1; pituitary tumor-transforming
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9232
PTTG2 GeneProduct ensembl:ENSBTAG00000047322 PTTG2; pituitary tumor-transforming
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10744
RB1 GeneProduct ensembl:ENSBTAG00000006640 RB1; retinoblastoma 1 (including osteosarcoma)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5925
CDC25B GeneProduct ensembl:ENSBTAG00000008436 CDC25B; cell division cycle 25B [EC:3.1.3.48]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:994
CDC25C GeneProduct ensembl:ENSBTAG00000005293 CDC25C; cell division cycle 25C [EC:3.1.3.48]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:995
CDK2 GeneProduct ensembl:ENSBTAG00000004021 CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1017
CDK4 GeneProduct ensembl:ENSBTAG00000046091 CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1019
CDK6 GeneProduct ensembl:ENSBTAG00000044023 CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1021
CCNH GeneProduct ensembl:ENSBTAG00000009566 CCNH; cyclin H
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:902
MAD1L1 GeneProduct ensembl:ENSBTAG00000002474 MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8379
GSK3B GeneProduct ensembl:ENSBTAG00000048057 GSK3B; glycogen synthase kinase 3 beta [EC:2.7.1.37]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2932
CCND3 GeneProduct ensembl:ENSBTAG00000010106 CCND3; cyclin D3
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:896
CCND2 GeneProduct ensembl:ENSBTAG00000016649 CCND2; cyclin D2
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:894
CDKN2A GeneProduct ensembl:ENSBTAG00000034220 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1029
CDKN1A GeneProduct ensembl:ENSBTAG00000008353 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1026
CCNE1 GeneProduct ensembl:ENSBTAG00000004735 CCNE1; cyclin E
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:898
CCNA1 GeneProduct ensembl:ENSBTAG00000007284 CCNA1; cyclin A1
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8900
CCNA2 GeneProduct ensembl:ENSBTAG00000004943 CCNA2; cyclin A2
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:890
PCNA GeneProduct ensembl:ENSBTAG00000006065 PCNA; proliferating cell nuclear antigen
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5111
YWHAG GeneProduct ensembl:ENSBTAG00000004077 YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptid
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7532
GADD45A GeneProduct ensembl:ENSBTAG00000013860 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1647
CDC25A GeneProduct ensembl:ENSBTAG00000009586 CDC25A; cell division cycle 25A [EC:3.1.3.48]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:993
HDAC1 GeneProduct ensembl:ENSBTAG00000012698 HDAC1; histone deacetylase 1
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3065
HDAC2 GeneProduct ensembl:ENSBTAG00000011849 HDAC2; histone deacetylase 2
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3066
HDAC3 GeneProduct ensembl:ENSBTAG00000017360 HDAC3; histone deacetylase 3
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8841
HDAC5 GeneProduct ensembl:ENSBTAG00000016254 HDAC5; histone deacetylase 5
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10014
HDAC6 GeneProduct ensembl:ENSBTAG00000013244 HDAC6; histone deacetylase 6
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10013
HDAC7 GeneProduct ensembl:ENSBTAG00000026819 HDAC7A; histone deacetylase 7
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51564
HDAC8 GeneProduct ensembl:ENSBTAG00000046092 HDAC8; histone deacetylase
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55869
TP53 GeneProduct ensembl:ENSBTAG00000001069 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7157
PRKDC GeneProduct ensembl:ENSBTAG00000017019 PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:2.7.1.37]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5591
CHEK1 GeneProduct ensembl:ENSBTAG00000017582 CHEK1; CHK1 checkpoint homolog (S. pombe) [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1111
CHEK2 GeneProduct ensembl:ENSBTAG00000004956 CHEK2; CHK2 checkpoint homolog (S. pombe) [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11200
MPEG1 GeneProduct ensembl:ENSBTAG00000045939 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:219972
MD2L1 GeneProduct ensembl:ENSBTAG00000035319 MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4085
CDK1 GeneProduct ensembl:ENSBTAG00000010109 CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:983
CCNB1 GeneProduct ensembl:ENSBTAG00000014239 CCNB1; cyclin B1
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:891
CCNB2 GeneProduct ensembl:ENSBTAG00000005269 CCNB2; cyclin B2
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9133
CCNB3 GeneProduct ensembl:ENSBTAG00000046286 CCNB3; cyclin B
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:85417
TFDP1 GeneProduct ensembl:ENSBTAG00000019645 TFDP1; transcription factor Dp-1
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7027
RBL1 GeneProduct ensembl:ENSBTAG00000011541 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5933
CDC7L1 GeneProduct ensembl:ENSBTAG00000016307 CDC7L1; CDC7 cell division cycle 7-like 1 (S. cerevisiae) [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8317
DBF4 GeneProduct ensembl:ENSBTAG00000014711 ASK; activator of S phase kinas
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10926
CDC45L GeneProduct ensembl:ENSBTAG00000004286 CDC45L; CDC45 cell division cycle 45-like (S. cerevisiae)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8318
CDC6 GeneProduct ensembl:ENSBTAG00000010384 CDC6; CDC6 cell division cycle 6 homolog (S. cerevisiae
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:990
CDKN1B GeneProduct ensembl:ENSBTAG00000018254 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1027
PKMYT1 GeneProduct ensembl:ENSBTAG00000004729 PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinas
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9088
SKP2 GeneProduct ensembl:ENSBTAG00000013562 SKP2; S-phase kinase-associated protein 2 (p45
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6502
CDC14A GeneProduct ensembl:ENSBTAG00000031439 CDC14A; CDC14 cell division cycle 14 homolog A (S. cerevisiae
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8556
CDC14B GeneProduct ensembl:ENSBTAG00000011589 CDC14B; CDC14 cell division cycle 14 homolog B (S. cerevisiae
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8555
E-CADHERIN GeneProduct ensembl:ENSBTAG00000015991 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:999
TBC1D8 GeneProduct ensembl:ENSBTAG00000025898 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11138
MEN1 GeneProduct ensembl:ENSBTAG00000002095 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4221
ESPL1 GeneProduct ensembl:ENSBTAG00000008934 ESPL1; extra spindle poles like 1 (S. cerevisiae
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9700
SMC1A GeneProduct ensembl:ENSBTAG00000017761 SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8243
MDM2 GeneProduct ensembl:ENSBTAG00000010422 MDM2; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4193
ARF1 GeneProduct ensembl:ENSBTAG00000007725 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:375
E2F1 GeneProduct ensembl:ENSBTAG00000003971 E2F1; E2F transcription factor 1
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1869
E2F2 GeneProduct ensembl:ENSBTAG00000014400 E2F2; E2F transcription factor 2
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1870
E2F3 GeneProduct ensembl:ENSBTAG00000021045 E2F3; E2F transcription factor 3
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1871
E2F5 GeneProduct ensembl:ENSBTAG00000009378 E2F5; E2F transcription factor 5 p130-binding
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1875
E2F4 GeneProduct ensembl:ENSBTAG00000012063 E2F4; E2F transcription factor 4 p107/p130-binding
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1874
RBL1 GeneProduct ensembl:ENSBTAG00000011541 RBL1; retinoblastoma-like 1 (p107)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5933
E2F6 GeneProduct ensembl:ENSBTAG00000048286 E2F6; E2F transcription factor 6
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1876
UBE2F GeneProduct ensembl:ENSBTAG00000026114 UBE2F; ubiquitin-conjugating enzyme E2F (UBC6 homolog C. elegans
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:140739
PLK1 GeneProduct ensembl:ENSBTAG00000014453 PLK; polo-like kinase (Drosophila) [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5347
SMAD3 GeneProduct ensembl:ENSBTAG00000012599 MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4088
TGFB1 GeneProduct ensembl:ENSBTAG00000020457 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7040
SMAD4 GeneProduct ensembl:ENSBTAG00000006919 MADH4; MAD mothers against decapentaplegic homolog 4 (Drosophila)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4089
HDAC4 GeneProduct ensembl:ENSBTAG00000017764 HDAC4; histone deacetylase 4
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9759
CCNE2 GeneProduct ensembl:ENSBTAG00000004906 CCNE2; cyclin E
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9134
CDC20 GeneProduct ensembl:ENSBTAG00000009819 CDC20; CDC20 cell division cycle 20 homolog (S. cerevisiae
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:991
APC GeneProduct ensembl:ENSBTAG00000018852 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:324
KITLG GeneProduct ensembl:ENSBTAG00000017549 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4254
MCM2 GeneProduct ensembl:ENSBTAG00000014380 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4171
YWHAG GeneProduct ensembl:ENSBTAG00000004077 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7532
YWHAB GeneProduct ensembl:ENSBTAG00000016846 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7529
YWHAE GeneProduct ensembl:ENSBTAG00000005664 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7531
YWHAH GeneProduct ensembl:ENSBTAG00000011631 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7533
YWHAQ GeneProduct ensembl:ENSBTAG00000002108 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10971
YWHAZ GeneProduct ensembl:ENSBTAG00000000236 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7534
MCM3 GeneProduct ensembl:ENSBTAG00000010721 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4172
MCM4 GeneProduct ensembl:ENSBTAG00000017021 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4173
MCM5 GeneProduct ensembl:ENSBTAG00000015595 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4174
MCM6 GeneProduct ensembl:ENSBTAG00000015172 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4175
MCM7 GeneProduct ensembl:ENSBTAG00000030965 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4176
MCM8 GeneProduct ensembl:ENSBTAG00000014623 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84515
MCM9 GeneProduct ensembl:ENSBTAG00000002059 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:254394
MCM10 GeneProduct ensembl:ENSBTAG00000016406 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55388
ORC1 GeneProduct ensembl:ENSBTAG00000002719 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4998
ORC2 GeneProduct ensembl:ENSBTAG00000031473 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4999
ORC3 GeneProduct ensembl:ENSBTAG00000016969 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23595
ORC4 GeneProduct ensembl:ENSBTAG00000015291 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5000
ORC5L GeneProduct ensembl:ENSBTAG00000040058 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5001
ORC6 GeneProduct ensembl:ENSBTAG00000001872 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23594
KITLG Protein ensembl:ENSBTAG00000017549 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4254

References

  1. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, et al. Science. 1998 Sep 11;281(5383):1677–9. PubMed Europe PMC Scholia