Cell cycle (WP1083)
Bos taurus
The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle. Sources: [http://en.wikipedia.org/wiki/Cell_cycle Wikipedia:Cell cycle], [http://www.genome.ad.jp/kegg/pathway/hsa/hsa04110.html KEGG]
Authors
Martijn Van Iersel , Martina Summer-Kutmon , Egon Willighagen , and Eric WeitzActivity
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Cited In
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Organisms
Bos taurusCommunities
Annotations
Pathway Ontology
cell cycle pathway, mitotic| Label | Type | Compact URI | Comment |
|---|---|---|---|
| BUB1B | GeneProduct | ensembl:ENSBTAG00000007237 | BUB1B; BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) [EC:2.7.1.-]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:701 |
| ATM | GeneProduct | ensembl:ENSBTAG00000003111 | ATM; ataxia telangiectasia mutated (includes complementation groups A C and D) [EC:2.7.1.37]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:472 |
| ABL1 | GeneProduct | ensembl:ENSBTAG00000017976 | ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1 [EC:2.7.1.112HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:25 |
| ATR | GeneProduct | ensembl:ENSBTAG00000011529 | ATR; ataxia telangiectasia and Rad3 relatedHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:545 |
| MAD2L2 | GeneProduct | ensembl:ENSBTAG00000013275 | MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10459 |
| BUB1 | GeneProduct | ensembl:ENSBTAG00000021181 | BUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) [EC:2.7.1.-]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:699 |
| BUB3 | GeneProduct | ensembl:ENSBTAG00000017913 | BUB3; BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9184 |
| EP300 | GeneProduct | ensembl:ENSBTAG00000016198 | EP300; E1A binding protein p300HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2033 |
| WEE1 | GeneProduct | ensembl:ENSBTAG00000005278 | WEE1; WEE1+ homolog (S. pombe) [EC:2.7.1.112]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7465 |
| PTTG1 | GeneProduct | ensembl:ENSBTAG00000047322 | PTTG1; pituitary tumor-transformingHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9232 |
| PTTG2 | GeneProduct | ensembl:ENSBTAG00000047322 | PTTG2; pituitary tumor-transformingHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10744 |
| RB1 | GeneProduct | ensembl:ENSBTAG00000006640 | RB1; retinoblastoma 1 (including osteosarcoma)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5925 |
| RB1 | GeneProduct | ensembl:ENSBTAG00000006640 | RB1; retinoblastoma 1 (including osteosarcoma)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5925 |
| CDC25B | GeneProduct | ensembl:ENSBTAG00000008436 | CDC25B; cell division cycle 25B [EC:3.1.3.48]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:994 |
| CDC25C | GeneProduct | ensembl:ENSBTAG00000005293 | CDC25C; cell division cycle 25C [EC:3.1.3.48]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:995 |
| CDK2 | GeneProduct | ensembl:ENSBTAG00000004021 | CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1017 |
| CDK2 | GeneProduct | ensembl:ENSBTAG00000004021 | CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1017 |
| CDK4 | GeneProduct | ensembl:ENSBTAG00000046091 | CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1019 |
| CDK6 | GeneProduct | ensembl:ENSBTAG00000044023 | CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1021 |
| CCNH | GeneProduct | ensembl:ENSBTAG00000009566 | CCNH; cyclin HHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:902 |
| MAD1L1 | GeneProduct | ensembl:ENSBTAG00000002474 | MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeastHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8379 |
| GSK3B | GeneProduct | ensembl:ENSBTAG00000048057 | GSK3B; glycogen synthase kinase 3 beta [EC:2.7.1.37]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2932 |
| CCND3 | GeneProduct | ensembl:ENSBTAG00000010106 | CCND3; cyclin D3HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:896 |
| CCND2 | GeneProduct | ensembl:ENSBTAG00000016649 | CCND2; cyclin D2HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:894 |
| CDKN2A | GeneProduct | ensembl:ENSBTAG00000034220 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1029 |
| CDKN1A | GeneProduct | ensembl:ENSBTAG00000008353 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1026 |
| CCNE1 | GeneProduct | ensembl:ENSBTAG00000004735 | CCNE1; cyclin EHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:898 |
| CCNA1 | GeneProduct | ensembl:ENSBTAG00000007284 | CCNA1; cyclin A1HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8900 |
| CCNA2 | GeneProduct | ensembl:ENSBTAG00000004943 | CCNA2; cyclin A2HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:890 |
| PCNA | GeneProduct | ensembl:ENSBTAG00000006065 | PCNA; proliferating cell nuclear antigenHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5111 |
| YWHAG | GeneProduct | ensembl:ENSBTAG00000004077 | YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptidHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7532 |
| GADD45A | GeneProduct | ensembl:ENSBTAG00000013860 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1647 |
| CDC25A | GeneProduct | ensembl:ENSBTAG00000009586 | CDC25A; cell division cycle 25A [EC:3.1.3.48]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:993 |
| HDAC1 | GeneProduct | ensembl:ENSBTAG00000012698 | HDAC1; histone deacetylase 1HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3065 |
| HDAC2 | GeneProduct | ensembl:ENSBTAG00000011849 | HDAC2; histone deacetylase 2HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3066 |
| HDAC3 | GeneProduct | ensembl:ENSBTAG00000017360 | HDAC3; histone deacetylase 3HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8841 |
| HDAC5 | GeneProduct | ensembl:ENSBTAG00000016254 | HDAC5; histone deacetylase 5HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10014 |
| HDAC6 | GeneProduct | ensembl:ENSBTAG00000013244 | HDAC6; histone deacetylase 6HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10013 |
| HDAC7 | GeneProduct | ensembl:ENSBTAG00000026819 | HDAC7A; histone deacetylase 7HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51564 |
| HDAC8 | GeneProduct | ensembl:ENSBTAG00000046092 | HDAC8; histone deacetylaseHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55869 |
| CDK2 | GeneProduct | ensembl:ENSBTAG00000004021 | CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1017 |
| TP53 | GeneProduct | ensembl:ENSBTAG00000001069 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7157 |
| PRKDC | GeneProduct | ensembl:ENSBTAG00000017019 | PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:2.7.1.37]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5591 |
| CHEK1 | GeneProduct | ensembl:ENSBTAG00000017582 | CHEK1; CHK1 checkpoint homolog (S. pombe) [EC:2.7.1.-]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1111 |
| CHEK2 | GeneProduct | ensembl:ENSBTAG00000004956 | CHEK2; CHK2 checkpoint homolog (S. pombe) [EC:2.7.1.-]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11200 |
| MPEG1 | GeneProduct | ensembl:ENSBTAG00000045939 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:219972 |
| MD2L1 | GeneProduct | ensembl:ENSBTAG00000035319 | MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4085 |
| CDK1 | GeneProduct | ensembl:ENSBTAG00000010109 | CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:983 |
| CCNA2 | GeneProduct | ensembl:ENSBTAG00000004943 | CCNA2; cyclin A2HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:890 |
| CCNA1 | GeneProduct | ensembl:ENSBTAG00000007284 | CCNA1; cyclin A1HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8900 |
| CCNB1 | GeneProduct | ensembl:ENSBTAG00000014239 | CCNB1; cyclin B1HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:891 |
| CCNB2 | GeneProduct | ensembl:ENSBTAG00000005269 | CCNB2; cyclin B2HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9133 |
| CCNB3 | GeneProduct | ensembl:ENSBTAG00000046286 | CCNB3; cyclin BHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:85417 |
| CDK1 | GeneProduct | ensembl:ENSBTAG00000010109 | CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:983 |
| RB1 | GeneProduct | ensembl:ENSBTAG00000006640 | RB1; retinoblastoma 1 (including osteosarcoma)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5925 |
| TFDP1 | GeneProduct | ensembl:ENSBTAG00000019645 | TFDP1; transcription factor Dp-1HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7027 |
| RBL1 | GeneProduct | ensembl:ENSBTAG00000011541 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5933 |
| CDC7L1 | GeneProduct | ensembl:ENSBTAG00000016307 | CDC7L1; CDC7 cell division cycle 7-like 1 (S. cerevisiae) [EC:2.7.1.-]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8317 |
| DBF4 | GeneProduct | ensembl:ENSBTAG00000014711 | ASK; activator of S phase kinasHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10926 |
| CDC45L | GeneProduct | ensembl:ENSBTAG00000004286 | CDC45L; CDC45 cell division cycle 45-like (S. cerevisiae)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8318 |
| CDC6 | GeneProduct | ensembl:ENSBTAG00000010384 | CDC6; CDC6 cell division cycle 6 homolog (S. cerevisiaeHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:990 |
| CDKN1B | GeneProduct | ensembl:ENSBTAG00000018254 | CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1027 |
| PKMYT1 | GeneProduct | ensembl:ENSBTAG00000004729 | PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinasHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9088 |
| SKP2 | GeneProduct | ensembl:ENSBTAG00000013562 | SKP2; S-phase kinase-associated protein 2 (p45HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6502 |
| SKP2 | GeneProduct | ensembl:ENSBTAG00000013562 | SKP2; S-phase kinase-associated protein 2 (p45HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6502 |
| CDC14A | GeneProduct | ensembl:ENSBTAG00000031439 | CDC14A; CDC14 cell division cycle 14 homolog A (S. cerevisiaeHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8556 |
| CDC14B | GeneProduct | ensembl:ENSBTAG00000011589 | CDC14B; CDC14 cell division cycle 14 homolog B (S. cerevisiaeHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8555 |
| E-CADHERIN | GeneProduct | ensembl:ENSBTAG00000015991 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:999 |
| TBC1D8 | GeneProduct | ensembl:ENSBTAG00000025898 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11138 |
| MEN1 | GeneProduct | ensembl:ENSBTAG00000002095 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4221 |
| ESPL1 | GeneProduct | ensembl:ENSBTAG00000008934 | ESPL1; extra spindle poles like 1 (S. cerevisiaeHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9700 |
| SMC1A | GeneProduct | ensembl:ENSBTAG00000017761 | SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeastHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8243 |
| MDM2 | GeneProduct | ensembl:ENSBTAG00000010422 | MDM2; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4193 |
| ARF1 | GeneProduct | ensembl:ENSBTAG00000007725 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:375 |
| E2F1 | GeneProduct | ensembl:ENSBTAG00000003971 | E2F1; E2F transcription factor 1HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1869 |
| E2F2 | GeneProduct | ensembl:ENSBTAG00000014400 | E2F2; E2F transcription factor 2HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1870 |
| E2F3 | GeneProduct | ensembl:ENSBTAG00000021045 | E2F3; E2F transcription factor 3HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1871 |
| E2F5 | GeneProduct | ensembl:ENSBTAG00000009378 | E2F5; E2F transcription factor 5 p130-bindingHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1875 |
| E2F4 | GeneProduct | ensembl:ENSBTAG00000012063 | E2F4; E2F transcription factor 4 p107/p130-bindingHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1874 |
| RBL1 | GeneProduct | ensembl:ENSBTAG00000011541 | RBL1; retinoblastoma-like 1 (p107)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5933 |
| E2F6 | GeneProduct | ensembl:ENSBTAG00000048286 | E2F6; E2F transcription factor 6HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1876 |
| UBE2F | GeneProduct | ensembl:ENSBTAG00000026114 | UBE2F; ubiquitin-conjugating enzyme E2F (UBC6 homolog C. elegansHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:140739 |
| PLK1 | GeneProduct | ensembl:ENSBTAG00000014453 | PLK; polo-like kinase (Drosophila) [EC:2.7.1.-]HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5347 |
| SMAD3 | GeneProduct | ensembl:ENSBTAG00000012599 | MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4088 |
| TGFB1 | GeneProduct | ensembl:ENSBTAG00000020457 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7040 |
| SMAD4 | GeneProduct | ensembl:ENSBTAG00000006919 | MADH4; MAD mothers against decapentaplegic homolog 4 (Drosophila)HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4089 |
| HDAC4 | GeneProduct | ensembl:ENSBTAG00000017764 | HDAC4; histone deacetylase 4HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9759 |
| CCNE2 | GeneProduct | ensembl:ENSBTAG00000004906 | CCNE2; cyclin EHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9134 |
| CDC20 | GeneProduct | ensembl:ENSBTAG00000009819 | CDC20; CDC20 cell division cycle 20 homolog (S. cerevisiaeHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:991 |
| APC | GeneProduct | ensembl:ENSBTAG00000018852 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:324 |
| APC | GeneProduct | ensembl:ENSBTAG00000018852 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:324 |
| KITLG | GeneProduct | ensembl:ENSBTAG00000017549 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4254 |
| MCM2 | GeneProduct | ensembl:ENSBTAG00000014380 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4171 |
| YWHAG | GeneProduct | ensembl:ENSBTAG00000004077 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7532 |
| YWHAB | GeneProduct | ensembl:ENSBTAG00000016846 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7529 |
| YWHAE | GeneProduct | ensembl:ENSBTAG00000005664 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7531 |
| YWHAH | GeneProduct | ensembl:ENSBTAG00000011631 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7533 |
| YWHAQ | GeneProduct | ensembl:ENSBTAG00000002108 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10971 |
| YWHAZ | GeneProduct | ensembl:ENSBTAG00000000236 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7534 |
| MCM3 | GeneProduct | ensembl:ENSBTAG00000010721 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4172 |
| MCM4 | GeneProduct | ensembl:ENSBTAG00000017021 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4173 |
| MCM5 | GeneProduct | ensembl:ENSBTAG00000015595 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4174 |
| MCM6 | GeneProduct | ensembl:ENSBTAG00000015172 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4175 |
| MCM7 | GeneProduct | ensembl:ENSBTAG00000030965 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4176 |
| MCM8 | GeneProduct | ensembl:ENSBTAG00000014623 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84515 |
| MCM9 | GeneProduct | ensembl:ENSBTAG00000002059 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:254394 |
| MCM10 | GeneProduct | ensembl:ENSBTAG00000016406 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55388 |
| ORC1 | GeneProduct | ensembl:ENSBTAG00000002719 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4998 |
| ORC2 | GeneProduct | ensembl:ENSBTAG00000031473 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4999 |
| ORC3 | GeneProduct | ensembl:ENSBTAG00000016969 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23595 |
| ORC4 | GeneProduct | ensembl:ENSBTAG00000015291 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5000 |
| ORC5L | GeneProduct | ensembl:ENSBTAG00000040058 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5001 |
| ORC6 | GeneProduct | ensembl:ENSBTAG00000001872 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23594 |
| KITLG | Protein | ensembl:ENSBTAG00000017549 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4254 |
References
- Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, et al. Science. 1998 Sep 11;281(5383):1677–9. PubMed Europe PMC Scholia