Colchicine metabolic pathway (WP3187)
Bos taurus
P450-mediated biotransformation pathway of colchicine with the CYP3A4, while colchicine inhibits the expression of this enzyme.
Authors
Martina Summer-Kutmon and Eric WeitzActivity
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Organisms
Bos taurusCommunities
Annotations
Pathway Ontology
phase I biotransformation pathway via cytochrome P450| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Colchicine | Metabolite | chemspider:5933 | |
| 3DMC | Metabolite | chemspider:264748 | |
| 2DMC | Metabolite | chemspider:22210 | |
| CYP3A4 | Protein | ensembl:ENSBTAG00000047379 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P08684 |
References
- Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation. Tateishi T, Soucek P, Caraco Y, Guengerich FP, Wood AJ. Biochem Pharmacol. 1997 Jan 10;53(1):111–6. PubMed Europe PMC Scholia
- Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation. Dvorak Z, Modriansky M, Pichard-Garcia L, Balaguer P, Vilarem MJ, Ulrichová J, et al. Mol Pharmacol. 2003 Jul;64(1):160–9. PubMed Europe PMC Scholia