ATM signaling pathway (WP654)

Rattus norvegicus


Ralph Straus , Thomas Kelder , Christine Chichester , Martina Summer-Kutmon , Kristina Hanspers , Eric Weitz , and Lars Willighagen


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Rattus norvegicus



Pathway Ontology

ataxia telangiectasia-mutated (ATM) signaling pathway p53-dependent G1/S DNA damage checkpoint pathway


Label Type Compact URI Comment
H2afx GeneProduct ncbigene:300668
Rb1 GeneProduct ncbigene:24708
Apaf1 GeneProduct ensembl:ENSRNOG00000008022
Cdk2 GeneProduct ncbigene:362817
Reprimo GeneProduct ncbigene:680110
Bcl2 GeneProduct ncbigene:24224
Tp53 GeneProduct ncbigene:24842
Bax GeneProduct ncbigene:24887
Atm GeneProduct ncbigene:300711
14-3-3 sigma GeneProduct ncbigene:298795
CytC GeneProduct ncbigene:25309
Cyclin D GeneProduct ncbigene:58919
CyclinB1 GeneProduct ncbigene:25203
Cdk6 GeneProduct ncbigene:114483
Chk2 GeneProduct ncbigene:114212
Rb1 GeneProduct ncbigene:24708
Cyclin E GeneProduct ncbigene:25729
Caspase9 GeneProduct ncbigene:58918
Brca1 GeneProduct ncbigene:497672
E2f1 GeneProduct ncbigene:399489
E2f1 GeneProduct ncbigene:399489
Cdkn1a GeneProduct ensembl:ENSRNOG00000000521
Caspase3 GeneProduct ncbigene:25402
Cdc2 GeneProduct ncbigene:54237
Pmaip1 GeneProduct ncbigene:492821
Gadd45a GeneProduct ncbigene:25112
Bak1 GeneProduct ncbigene:116502


  1. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ. Cell. 1993 Nov 19;75(4):805–16. PubMed Europe PMC Scholia
  2. Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis. Kothakota S, Azuma T, Reinhard C, Klippel A, Tang J, Chu K, et al. Science. 1997 Oct 10;278(5336):294–8. PubMed Europe PMC Scholia
  3. Bax directly induces release of cytochrome c from isolated mitochondria. Jürgensmeier JM, Xie Z, Deveraux Q, Ellerby L, Bredesen D, Reed JC. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):4997–5002. PubMed Europe PMC Scholia
  4. Reprimo, a new candidate mediator of the p53-mediated cell cycle arrest at the G2 phase. Ohki R, Nemoto J, Murasawa H, Oda E, Inazawa J, Tanaka N, et al. J Biol Chem. 2000 Jul 28;275(30):22627–30. PubMed Europe PMC Scholia
  5. BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations. Ye Q, Hu YF, Zhong H, Nye AC, Belmont AS, Li R. J Cell Biol. 2001 Dec 10;155(6):911–21. PubMed Europe PMC Scholia
  6. Histone H2A variants H2AX and H2AZ. Redon C, Pilch D, Rogakou E, Sedelnikova O, Newrock K, Bonner W. Curr Opin Genet Dev. 2002 Apr;12(2):162–9. PubMed Europe PMC Scholia
  7. Cell cycle arrest and repression of cyclin D1 transcription by INI1/hSNF5. Zhang ZK, Davies KP, Allen J, Zhu L, Pestell RG, Zagzag D, et al. Mol Cell Biol. 2002 Aug;22(16):5975–88. PubMed Europe PMC Scholia
  8. The multiple nuclear functions of BRCA1: transcription, ubiquitination and DNA repair. Starita LM, Parvin JD. Curr Opin Cell Biol. 2003 Jun;15(3):345–50. PubMed Europe PMC Scholia
  9. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M, et al. Science. 2004 Feb 13;303(5660):1010–4. PubMed Europe PMC Scholia
  10. G2 cell cycle arrest, down-regulation of cyclin B, and induction of mitotic catastrophe by the flavoprotein inhibitor diphenyleneiodonium. Scaife RM. Mol Cancer Ther. 2004 Oct;3(10):1229–37. PubMed Europe PMC Scholia
  11. ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. Chen L, Gilkes DM, Pan Y, Lane WS, Chen J. EMBO J. 2005 Oct 5;24(19):3411–22. PubMed Europe PMC Scholia