Phospholipid biosynthesis (WP9)

Saccharomyces cerevisiae

Sphingolipids are essential components of the plasma membrane in all eukaryotic cells. S. cerevisiae cells make three complex sphingolipids: inositol-phosphoceramide (IPC), mannose-inositol-phosphoceramide (MIPC), and mannose-(inositol phosphate)2-ceramide (M(IP)2C)(CITS: [12069845]). In the yeast plasma membrane sphingolipids concentrate with ergosterol to form lipid rafts, specialized membrane microdomains implicated in a variety of cellular processes, including sorting of membrane proteins and lipids, as well as organizing and regulating signaling cascades (CITS: [12452424]). Intermediates in sphingolipid biosynthesis have been shown to play important roles as signaling molecules and growth regulators. Sphingolipid long chain bases (LCBs), dihydrosphingosine (DHS) and phytosphingosine (PHS), have been implicated as secondary messengers in signaling pathways that regulate heat stress response (CITS: [9405471])(CITS: [11967828]). Other intermediates, phytoceramide and long-chain base phosphates (LCBPs), have been shown to be components of the tightly-controlled ceramide/LCBP rheostat, which regulates cell growth (CITS: [12684378]). Since phosphoinositol-containing sphingolipids are unique to fungi, the sphingolipid biosynthesis pathway is considered a target for antifungal drugs (CITS: [9092515])(CITS: [15578972]). SOURCE: SGD pathways,


Meredith Braymer , Egon Willighagen , Daniela Digles , Martina Summer-Kutmon , and Eric Weitz


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Saccharomyces cerevisiae



Pathway Ontology

glycerophospholipid metabolic pathway


Label Type Compact URI Comment
phosphate Metabolite cas:14265-44-2
L-1-phosphatidyl-ethanolamine Metabolite cas:2644-64-6
L-serine Metabolite cas:56-45-1
glycerol Metabolite cas:56-81-5
pyrophosphate Metabolite cas:2466-09-3
OPI3 GeneProduct sgd:S000003834
CHO2 GeneProduct sgd:S000003389
CHO1 GeneProduct sgd:S000000828
CDS1 GeneProduct sgd:S000000233
PSD2 GeneProduct sgd:S000003402
PSG1 GeneProduct sgd:S000000510
OPI3 GeneProduct sgd:S000003834
CRD1 GeneProduct sgd:S000002301
PSD1 GeneProduct sgd:S000005113


  1. Regulation of phospholipid synthesis in Saccharomyces cerevisiae by zinc depletion. Carman GM, Han GS. Biochim Biophys Acta. 2007 Mar;1771(3):322–30. PubMed Europe PMC Scholia